GTA-Net: Cooperative Game Theory for Vision-Language Alignment in Chest X-Ray Report Generation
Authors: Saif ur Rehman Khan, Imad Ahmed Waqar, Sebastian Vollmer, Andreas Dengel, Muhammad Nabeel Asim
Abstract
Automated chest X-ray report generation requires precise cross-modal grounding to ensure clinically reliable descriptions. However, existing vision-language models rely on implicit attention mechanisms that fail to enforce explicit region-word correspondence and disease-level consistency. We propose Game-Theoretic Alignment Network (GTA-Net), a vision-language framework that formulates report generation as a cooperative game-theoretic alignment problem. The model introduces a BinaryGameAligner that models interactions between image regions and text tokens using similarity-based payoff matrices with Shapley-inspired importance weighting. To enforce clinical semantics, we further develop a Disease-Aware Ternary Aligner, which captures joint interactions among images, reports, and structured disease concepts. GTA-Net combines a Swin-based visual encoder with a LoRA-adapted large language model and is trained with a unified objective for generation and alignment. Experiments on CheXpertPlus and IU-XRay demonstrate state-of-the-art performance across standard generation metrics and improved clinical consistency, highlighting the effectiveness of explicit game-theoretic alignment for medical vision-language generation.
Medical imaging is a cornerstone of diagnostics, yet automated chest X-ray report generation struggles with structural adherence, anatomical completeness, and semantic faithfulness. We introduce DobicVLM, a vision-language model combining supervised fine-tuning on MedGemma-4B with Group Relative Policy Optimization (GRPO) and clinically-grounded programmatic rewards. Our approach uses interpretable, rule-based reward components; structural verification, anatomical checklist, semantic similarity, and length constraints to enforce clinical standards without neural reward models. Trained on 1,000 de-identified image-report pairs from a private clinical dataset (with ethics approval and compliance to local regulations), DobicVLM is evaluated via blinded expert review on 69 held-out cases. DobicVLM outperforms Gemini 2.5 Flash across the majority of criteria, achieving the highest impression accuracy (27.2%) and medical terminology (86.5%) compared to both Gemini 2.5 Flash and MedGemma 4B baselines, with minor trade-offs in completeness and referrals. This demonstrates GRPO's value for transparent alignment in resource-limited settings. Keywords: Vision-Language Models, Radiology Report Generation, Reinforcement Learning, Medical AI, GRPO
A clinically useful chest X-ray system must go beyond fluent report generation: it should classify findings with tunable decision thresholds, localize them spatially, and derive the anatomical measurements upon which many diagnoses depend. Today's Vision-Language Models (VLMs) treat these as separate problems, if they address them at all, leaving a gap between what radiologists need and what generative models provide. We introduce CARE-X, a chest X-ray VLM that narrows this gap by unifying auxiliary discriminative supervision with reward-aligned generation. CARE-X augments its generative backbone with focal-loss classification and composite-loss grounding heads, co-trained alongside the language-modeling objective. This auxiliary supervision produces discriminative diagnostic predictions with tunable decision thresholds and precise spatial localization while also improving report quality, providing evidence that structured prediction and generation reinforce one another. Building on this foundation, Decoupled Clip and Dynamic Sampling Policy Optimization (DAPO) leverages task-specific reward signals for report generation, visual question answering (VQA), and spatial grounding, directly optimizing the clinical quality metrics that matter in practice. The result is state-of-the-art performance on the majority of metrics across four report-generation benchmarks, 94.0% VQA accuracy on ReXVQA (+6.0 pp over the next-best baseline), and generative spatial decoding that reaches near parity with dedicated detection heads. Separately, to address measurement-dependent diagnoses, we couple Qwen3-VL-4B-Instruct with native tool-calling capabilities for invoking deterministic measurement tools, while retaining full visual access to the image. This hybrid inference yields +43.6 pp average F1 over perception-only baselines across five measurement-dependent conditions.
Mercy Prasanna Ranjit, Anirban Porya, Sathvik Joel +8
Recent radiology-adapted vision-language models have achieved strong performance on standard report generation benchmarks, yet their robustness and generalization remain constrained by imperfect alignment and correlation between visual and textual features. Existing methods connect image and text either implicitly through autoregressive report supervision or explicitly through contrastive learning. However, autoregressive supervision alone is insufficient to establish reliable image-text alignment, while contrastive learning can push apart unpaired reports that describe related pathologies simply because they are not paired with the same image. This is problematic in radiology, where different reports may share compatible pathology semantics rather than being true negatives. As a result, the learned representation may fail to organize images and reports around shared pathology concepts, causing the decoder to rely on pretrained language priors and generate clinically plausible reports that are not fully supported by radiographic evidence. To address this issue, we propose PALM, a pathology-aware alignment framework for radiology report generation. Instead of directly matching each image-report pair while separating all others, PALM aligns visual and textual features through shared pathology prototypes. These prototypes provide a clinically meaningful bridge between radiographic evidence and textual findings, allowing cases with similar pathology semantics to move toward common concepts without separating compatible cases. In addition, we introduce Masked Evidence Modeling to strengthen the image encoder sensitivity to local radiographic evidence by learning semantic changes caused by masked image regions. Experiments on MIMIC-CXR, IU X-Ray, and MIMIC-ABN show that PALM consistently improves both report generation and abnormality-focused robustness.