Autonomous microrobots navigating biological vasculature could enable targeted drug delivery and thrombolysis, yet training control policies for realistic environments remains an open challenge. Prior reinforcement learning (RL) studies of microrobotic navigation have been limited to idealized geometries that omit complex hydrodynamic flow fields, confined branching structures, and dense cellular obstacles found in vivo. Here, we develop a physically grounded simulation of a blood capillary network, incorporating realistic hydrodynamic flow fields, explicit red blood cell dynamics, and anatomically derived branching geometry, and train deep RL agents to navigate it via chemotaxis. We systematically map the physical limits of navigation across robot size and swimming speed, revealing a forbidden regime where Brownian motion and flow overcome propulsion. Successful agents independently discover multiple universal strategy types, including run-and-rotate and energy-efficient search-and-sit policies, regardless of robot parameters. Without retraining, these agents perform targeted blocking and unblocking of capillary flow, restoring throughput to healthy baseline levels. These results establish RL as a viable framework for developing autonomous microrobotic intervention strategies in complex biological environments.
Microrobots hold significant potential for various applications, where targeted navigation is a basic requirement. Deep reinforcement learning (DRL) has recently emerged as a powerful paradigm for fully autonomous microrobot navigation. Yet, current DRL-based approaches pay limited attention to learning efficiency and effectiveness, requiring hours to days for model training. Consequently, this impedes both rapid practical deployment and parameter optimization. To address these challenges, we present a learning framework that enables effective microrobot navigation policies to be trained within minutes. In the proposed framework, we develop a fully vectorized simulator with more than 10,000 artificial vascular environments, parallelizing dynamics, LiDAR-inspired perception, and feasibility checks across thousands of environments to achieve roughly 190,000 transitions per second. To achieve effectiveness in fast training, we propose a task-shaping-regularization (TSR) reward framework. The TSR framework accelerates convergence, improves final performance, reduces action variation by at least 33.7%, and increases obstacle clearance by at least 2.1% across all evaluated scenarios. Results show that the proposed learning framework reduces training time to under 10 minutes, while supporting zero-shot deployment across distinct microrobot types and navigation scenarios. Collectively, this framework can substantially shorten the design loop and accelerate the deployment of autonomous microrobots.
Autonomous microrobots could enable minimally invasive interventions in confined biological environments, but their operation requires real-time navigation among moving obstacles and environmental disturbances. Here we present a closed-loop framework for autonomous magnetic microrobot navigation that separates long-range geometric planning from short-range reactive control. An analytic geometry-based planner continuously generates collision-free global routes from microscopy images, while rule-based or reinforcement-learning local controllers respond to moving obstacles before returning control to the replanned global route. The planner produces short paths with substantially lower computation time than representative graph-, sampling- and geometry-based planners, and the integrated framework operates within the video-rate control budget. We demonstrate microrobot autonomous navigation in static and dynamic microfluidic environments, including avoidance of moving particles and human red blood cells, navigation with and against fluid flow, and repeated long-duration target transitions. We further demonstrate magnetic microrobot actuation in ex vivo ocular and vascularized cortical tissues and photoacoustic detection of magnetically induced microrobot dynamics in post-mortem tissue. These results establish a modular framework for autonomous magnetic microrobot navigation in complex biological environments.
Yanda Yang, Max Sokolich, Fatma Ceren Kirmizitas +3
Coordinating micro-robotic swarms in realistic, time-dependent fluid environments remains a major challenge for biomedical and environmental applications. We present a hybrid CFD-MO-MARL (Computational Fluid Dynamics-Multi Objective-Multi Agent Reinforcement Learning) framework that couples a high-fidelity incompressible Navier--Stokes solver with decentralized proximal policy optimization to learn swarm control policies in oscillatory flow. Sixteen magnetically actuated micro-robots were simulated to navigate a pulsatile arterial waveform within a 2 mm channel while jointly optimizing upstream progression, energy efficiency, and motion smoothness. Conflicting objectives are resolved using Projected Conflicting Gradient (PCGrad) surgery. Without PCGrad, energy and smoothness rewards collapse during training, demonstrating that gradient conflict resolution is essential for stable multi-objective learning. The converged policy achieves progress rewards of 6.5-7.0, energy efficiency of 0.63-0.65, and smoothness of 0.97-0.99, outperforming brute-force baselines by more than 8 reward units on the primary objective. Training reveals three emergent behaviors not encoded in the reward function: hydrodynamic throttling formations that reduce peak flow velocities, a cycle-synchronized ratchet mechanism that exploits flow reversals for upstream movement, and individualized final-approach strategies near the target boundary. These results demonstrate that physically realistic fluid--agent interactions can be integrated directly into multi-objective reinforcement learning, providing a scalable framework for micro-swarm control in biomedical navigation, environmental monitoring, and microfluidic systems.