FedProIn: Mitigating Client Drift for Learnable Prototypes in Federated Medical Imaging

Federated Learning (FL) enables collaborative training of distributed clients while protecting privacy. To enhance generalization capability in FL, prototype-based FL is in the spotlight, since shared global prototypes offer semantic anchors for aligning client-specific local prototypes. However, existing methods update global prototypes at the prototype-level via averaging local prototypes or refining global anchors, which often leads to semantic drift across clients and subsequently yields a misaligned global signal. To alleviate this issue, we introduce hyper-prototypes, defined by a set of learnable global class-wise prototypes to preserve underlying semantic knowledge across clients. The hyper-prototypes are optimized via gradient matching to align with class-relevant characteristics distilled directly from clients' real samples, rather than prototype-level descriptors. We further propose FedHPro, a Federated Hyper-Prototype Learning framework, to leverage hyper-prototypes to promote inter-class separability via mutual-contrastive learning with client-specific margin, while encouraging intra-class uniformity through a consistency penalty. Comprehensive experiments under diverse heterogeneous scenarios confirm that 1) hyper-prototypes produce a more semantically consistent global signal, and 2) FedHPro achieves state-of-the-art performance on several benchmark datasets. Code is available at \href{https://github.com/mala-lab/FedHPro}{https://github.com/mala-lab/FedHPro}.

Federated learning enables collaborative model training across medical institutions without sharing raw data, but its performance is often limited by domain heterogeneity across clients. Existing approaches to address this challenge fall into two main paradigms: model-side personalization, which adapts model parameters to each client, and data-side harmonization, which reduces inter-client variation at the input level. Despite their widespread use, these strategies have not been systematically compared. In this work, we conduct a comprehensive study across six medical imaging settings-colon polyp, skin lesion, and breast tumor segmentation, and tuberculosis CXR, brain tumor, and breast tumor classification-covering diverse types of domain shift. We evaluate a broad set of state-of-the-art harmonization and personalization methods under a unified framework. Our results reveal a conditional trade-off driven by the nature of heterogeneity: harmonization is more effective when variation is primarily appearance-based (e.g., CXR classification), while personalization performs better when differences are structural (e.g., colon polyp segmentation). When inter-client variation is limited, both strategies perform similarly. These findings demonstrate that the effectiveness of adaptation in federated medical imaging depends on the type and magnitude of domain shift rather than the strategy alone. We provide practical guidelines for selecting between harmonization and personalization and highlight directions for future hybrid approaches that combine both paradigms. Code is available at https://github.com/ChamaniS/WhenToAdapt.

Federated learning (FL) enables collaborative model training without sharing raw patient data, but standard approaches such as FedAvg treat each client as a black box and provide no mechanism for isolating an adversarial contributor, auditing per-client influence, or honoring a departed participant's right to be forgotten. We present Fed-FBD (Federated Functional Block Diversification), a modular federated architecture that decomposes a ResNet backbone into six functional blocks (the stem, four residual groups, and the classification head) and maintains a warehouse of N color variants, each assembled from independently tracked and contributor-stamped blocks. Fed-FBD provides three capabilities absent in FedAvg: (i) architecturally guaranteed block-level isolation, so that an adversarial or mislabelled client cannot contaminate the clean colous; (ii) privacy-by-design, where membership inference advantage is already indistinguishable from chance before any privacy mechanism is applied; and (iii) surgical machine unlearning of a departed participant's contribution at sub-second cost and without retraining. Experiments on six MedMNIST-2D datasets, PathMNIST at 224x224, and CIFAR-10 show that Fed-FBD trades a modest 0.3%-3.1% IID accuracy gap on the adequately sized datasets for these guarantees, remains within 0.8%-4.0% of FedAvg at Dirichlet alpha=1.0 on three of four datasets, and confines all six adversarial attacks we study to the poisoned client's own blocks with at most +/-0.01 AUC drift on the clean colors.