AI-guided stimuli discovery and generation to optimize facial emotion perception studies in autism

The perceptual representations supporting our ability to recognize faces remain a computational mystery. Deep neural networks offer mechanistic hypotheses for human face perception, but theoretically distinct models often make indistinguishable representational predictions for randomly sampled faces. To expose diagnostic differences among these hypotheses, we compared six neural network models sharing an architecture but trained on distinct tasks, using face pairs optimized to elicit contrasting model predictions ("controversial" pairs) alongside randomly sampled pairs. We tested model predictions against face-dissimilarity judgments from 864 human participants across stimulus sets differing in realism and pose variation. Models prioritizing high-level, invariant structures (trained via inverse rendering, face identification, or object classification) most robustly matched human judgments. Furthermore, models trained on natural images typically outperformed synthetic-trained counterparts. Together, these findings suggest that human face perception is shaped by mechanisms that infer latent causes of facial appearance, discount nuisance variation, and are tuned by natural image statistics.

Synthetic faces from text-to-image (T2I) models pervade digital media, yet their demographic biases under emotionally conditioned prompts remain poorly understood. We aim to systematically audit how emotionally conditioned prompts affect demographic and perceived-attractiveness biases in synthetic faces generated by T2I models, with particular attention to intersectional patterns and cross-ecosystem differences across model families. We audited eight (4 Western and 4 Chinese) T2I models and generated 56,000 faces under seven prompt conditions: a neutral baseline and six emotion conditions. We quantified biases in gender, race, age, and perceived attractiveness using information-theoretic divergence metrics. We further conducted intersectional analyses across combined demographic attributes and compared patterns between the Western and Chinese model groups to assess cross-ecosystem consistency and divergence in bias behavior. All models show strong overrepresentation of young faces, and most also overrepresent White-coded individuals. Intersectional analysis reveals compound underrepresentation or near-erasure of specific demographic combinations, such as young x female x Black faces, which are largely absent across models and are not captured by single-attribute audits. Emotion prompts act as additional demographic selectors: negatively valenced emotions (including sadness and fear) consistently shift outputs toward White, middle-aged, male-coded faces. This produces a valence-driven mapping that is also associated with lower perceived attractiveness in generated faces. These findings indicate that demographic bias in T2I face generation is both pervasive and shaped by emotional conditioning. They underscore the need for intersectional, emotion-conditioned, and multilingual demographic audits as part of standard pre-deployment evaluation practices.

Autism spectrum disorder (ASD) affects over 75 million individuals worldwide, yet scalable computational methods for remote behavioral screening remain limited. This study addresses two complementary challenges in automated detection of autism-related self-stimulatory behaviors from video: (1) identifying the optimal sequence-based neural network architecture and temporal sampling rate, and (2) characterizing data augmentation strategies for training on small behavioral datasets. For the first objective, long short-term memory (LSTM) and gated recurrent unit (GRU) models were trained on pose-derived features from the Self-Stimulatory Behavior Diagnosis (SSBD) dataset at frame sampling intervals of 1, 5, 15, 30, 45, and 90 frames. Both architectures exceeded prior convolutional neural network (CNN) baselines (62-76% accuracy), with peak accuracies of 97.5% (LSTM) and 98.75% (GRU) at a sampling interval of every 15 frames. For the second objective, ten data augmentation strategies were applied to an I3D transfer learning pipeline, with an ablation study quantifying the marginal contribution of each technique. Horizontal flip achieved the highest standalone accuracy (48.78%), while exclusion of upsampling from the augmentation pipeline produced the largest performance degradation, indicating its necessity for complex behavioral video augmentation. A personalized machine learning approach, in which per-subject models were trained and tested on temporally split segments of each video, produced consistent predictions (mean loss 1.84, SD 0.79). These results provide practitioners with concrete guidance on architecture selection, sampling rate, and augmentation strategy for video-based behavioral classification in data-scarce clinical domains.