Soft Eversion Robots for Colonoscopy: Challenges, Open Problems, and Emerging Solutions

Soft eversion robots, also known as vine robots, have attracted growing interest for navigation and inspection tasks, including minimally invasive medical applications [1]. A vine robot consists of a thin, flexible, inextensible tube folded inward that everts and grows forward when pressurized. This tip-growth enables navigation with minimal friction, making vine robots well suited for complex environments such as the human colon [2]. While their inherent softness allows passive conforma- tion to curved pathways in confined spaces, navigation performance strongly depends on environmental inter- actions, including contact angle and the length of un- constrained deployed material [3], [4]. Sharp directional changes, such as those in the sigmoid colon, often limit passive growth and necessitate active steering. Existing solutions include distributed artificial muscles [5] or dedicated tip-based steering mechanisms [6]. In addition, many applications require payload delivery, such as sensors and tools [7], [8]. Within the ERC Synergy project EndoTheranostics, this motivates the development of vine robots capable of delivering micro- surgical tools during growth. Prior work has integrated working channels within the vine body [8], [9], but these approaches constrain tool size, introduce friction, and limit access to the environment to the robot tip. In this work, we propose a multi-vine architecture in which two vine robots are coupled to an externally integrated working channel via soft mounting tips [10]. Independent vine actuation enables active tip steering while advancing the working channel without embed- ding it within the vine bodies Figure 1. Experiments demonstrate sharp steering of nearly 90 degrees during growth, highlighting the potential of this architecture for versatile medical and non-medical applications.

Safe navigation within the spinal subarachnoid space is constrained by its narrow, compliant, and delicate anatomy. Conventional catheters and continuum robots rely on proximal pushing, generating friction and shear along the tissue device interface that limit distal controllability and increase the risk of neural injury. Here, we present a 2 mm diameter eversion-growing robotic platform that enables friction minimised extension and steering within the human spinal subarachnoid space, validated through computational modelling, phantom experiments, and intact human cadaver studies. The robot integrates a miniature endoscope for real time intrathecal visualisation and advances by pressure driven tip eversion, localising motion to the distal tip while minimising translational sliding of the deployed body. Phantom experiments demonstrated reductions of 65.2% in mean interaction force and 48.0% in peak interaction force compared with matched push-based insertion. Physics based modelling showed that eversion based growth redistributed tissue loading, reducing local stress concentrations and interfacial shear relative to conventional insertion. In an intact human cadaver, the system achieved 150 mm of controlled intrathecal extension with concurrent fluoroscopic and endoscopic visualisation, providing access across multiple vertebral levels from a standard lumbar entry point. Postprocedural laminectomy and durotomy revealed no observable macroscopic disruption of the dura mater or surrounding neural structures. These results provide the first mechanically characterised and multimodally validated demonstration of eversion-based robotic navigation in intact human spinal anatomy, establishing a quantitative and procedural foundation for future intrathecal interventions. Further validation in larger anatomical cohorts and under physiological conditions will be required before clinical translation.

Robot-assisted endovascular intervention can potentially reduce radiation exposure, improve surgeon ergonomics, enable telesurgery, support active assistance and autonomy, and enhance procedural precision. However, existing systems often suffer from limited procedural coverage because constrained patient-side setups, restricted flexibility, and complex instrument exchange hinder clinical workflow integration. This work presents a compact robotic system for endovascular interventions that enables continuous translational and rotational manipulation of standard endovascular instruments. The system consists of two alternating carts with pneumatically actuated membrane grippers integrated into rotating gripper gears. Its top-loading design allows rapid exchange of instruments such as guidewires and catheters without changing the robotic setup. A leader-follower control strategy enables continuous motion despite the finite stroke of each cart. The system was evaluated in motion-tracking experiments with guidewires and catheters and in an in vitro vascular phantom. The motion-tracking experiments showed generally smooth translational and rotational motion profiles. Across all tested guidewire and catheter experiments, the mean relative tracking errors were 3.6% for translational motion and 4.1% for rotational motion. In the vascular phantom, robot-assisted navigation reached the target in most trials, demonstrating the feasibility of the proposed manipulation concept under in vitro conditions. The presented robotic system demonstrates technical feasibility for continuous manipulation of standard endovascular instruments in bench-top and in vitro experiments. The compact top-loading design may ease instrument exchange and clinical workflow integration. Future work will focus on improving gripping performance, actuation speed, force feedback, and evaluation in more clinically realistic settings.