Abstract
Large language models used for clinical diagnostic reasoning are sensitive to sociolinguistic register, not just clinical content. We term this failure mode Narrative Anchoring: identical clinical facts expressed in different registers cause diagnostic outputs to diverge. Unlike prior demographic-bias work, which manipulates explicit identity tokens such as race or income, our benchmark isolates register as the sole channel of variation, with no demographic marker present in any form. We construct a dataset of 1,000 USMLE clinical vignettes, each rewritten into three sociolinguistically distinct personas under an independently audited fact-preservation guarantee, verified by a separate model that never sees the generation prompt. Across seven language models spanning three architecture families and scales, Narrative Anchoring is statistically significant under direct prompting in every model tested, with a Narrative Anchoring Gap of 0.064 to 0.151. Chain-of-thought reasoning and explicit debiasing instructions reduce the bias only partially, and their apparent gains are frequently confounded by accuracy collapse. We introduce NarrativeShield, a three-agent pipeline that structurally extracts and verifies clinical facts before diagnostic reasoning begins, reducing the Narrative Anchoring Gap to near-zero (−0.004 to 0.037) and achieving the lowest rate of severely unstable decisions (DSS < 0.8) of any method across all models, at a modest and mechanistically expected accuracy cost for most models. A stress test using a non-instruction-tuned base model shows that executing a debiasing intervention at all is gated by zero-shot instruction-following ability, not prompt content alone. We release our dataset, human-validated for fact preservation, as a standalone resource for studying register-based clinical bias.
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May 18, 2026cs.CL
Large language models (LLMs) are increasingly explored for clinical decision support, yet most evaluations are conducted in English, leaving their reliability in other languages uncertain. Here we evaluate the impact of prompting language on diagnostic reasoning and final diagnosis accuracy by comparing English and French performance across five LLMs (o3, DeepSeek-R1, GPT-4-Turbo, Llama-3.1-405B-Instruct, and BioMistral-7B). A total of 180 clinical vignettes covering 16 medical specialties were assessed by two physicians using an 18-point scale evaluating both diagnosis accuracy and reasoning quality. Four of the five models performed better in English (mean difference 0.37-0.91, adjusted p < 0.05), with the gap spanning multiple aspects of reasoning, including differential diagnosis, logical structure, and internal validity. o3 was the only model showing no overall language effect. These findings demonstrate that prompting language remains a critical determinant of LLM clinical performance, with implications for equitable linguistico-cultural deployment worldwide.
Adrien Bazoge, Josselin Corvellec, Sofiane Djillali Sid-Ahmed +1
Apr 20, 2026cs.CY
Large language models (LLMs) are increasingly used in clinical settings, raising concerns about racial bias in both generated medical text and clinical reasoning. Existing studies have identified bias in medical LLMs, but many focus on single models and give less attention to mitigation. This study uses the EU AI Act as a governance lens to evaluate five widely used LLMs across two tasks, namely synthetic patient-case generation and differential diagnosis ranking. Using race-stratified epidemiological distributions in the United States and expert differential diagnosis lists as benchmarks, we apply structured prompt templates and a two-part evaluation design to examine implicit and explicit racial bias. All models deviated from observed racial distributions in the synthetic case generation task, with GPT-4.1 showing the smallest overall deviation. In the differential diagnosis task, DeepSeek V3 produced the strongest overall results across the reported metrics. When embedded in an agentic workflow, DeepSeek V3 showed an improvement of 0.0348 in mean p-value, 0.1166 in median p-value, and 0.0949 in mean difference relative to the standalone model, although improvement was not uniform across every metric. These findings support multi-metric bias evaluation for AI systems used in medical settings and suggest that retrieval-based agentic workflows may reduce some forms of explicit bias in benchmarked diagnostic tasks. Detailed prompt templates, experimental datasets, and code pipelines are available on our GitHub.
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May 17, 2026cs.CL
Large Language Models (LLMs) are increasingly deployed in high-stakes domains such as clinical decision support and medical documentation. However, the robustness of these models against subtle linguistic variations, specifically stigmatizing language (SL) commonly found in human-authored clinical notes, remains critically under-explored. In this work, we investigate whether frontier LLMs inherit and propagate this human bias when processing clinical text. We systematically evaluate nine frontier LLMs across four stigmatized medical conditions, utilizing clinical vignettes injected with varying intensities and phenotypes of SL (doubt, blame, and maligning). Our results demonstrate that all evaluated models exhibit substantial bias, with clinical decision-making significantly skewed towards less aggressive patient management. Notably, we observe a high sensitivity to linguistic framing, where a single SL sentence is sufficient to alter model outputs, revealing a clear dose-response relationship. Furthermore, we evaluate standard prompt-based mitigation strategies, including Chain-of-Thought (CoT) reasoning and model self-debiasing. These approaches show limited efficacy; models struggle to explicitly identify SL while remaining implicitly influenced by it. Our findings expose a critical vulnerability in current LLMs regarding fairness and robustness in clinical NLP, underscoring the need for rigorous algorithmic guardrails to prevent the automation of health disparities.
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