Research Assistant: AstraZeneca's Agentic System for R&D

Agentic large language model (LLM) systems are reshaping scientific workflows in chemistry and drug discovery, but evaluating their open-ended, tool-augmented outputs remains a fundamental bottleneck. The LLM-as-a-Judge paradigm has emerged as a scalable alternative, but existing drug discovery benchmarks deploy LLM judges without validating their alignment with human experts. In this work, we present an LLM-as-a-Judge evaluation framework for ChatInvent, an agentic drug discovery assistant deployed at AstraZeneca, with five contributions. First, we define four output-quality evaluation dimensions---Completeness, Relevancy, Structural Clarity, and Scope Adherence---alongside deterministic Tool Call Correctness checks. Second, we validate the judge through a human alignment study with five expert annotators, comparing Gemini 3.1 Pro, Claude Opus 4.7, GPT-5, and Llama 3.1 70B as candidate judges. Third, we optimize the best-performing judge using few-shot demonstrations of human-annotated examples, improving alignment with the human majority vote from 0.80 to 0.86. Fourth, applying the optimized judge to 70 held-out questions, we surface concrete limitations and find no strong evidence that informal phrasing degrades output quality; it may, however, still be helpful to have the LLM rewrite the original question before querying the agent. Finally, we extend the framework to 38 adversarial questions that are ambiguous, invalid, out-of-scope or ethically sensitive, and show that the agent's refusal behavior is guided by the stated intent of a request. Our framework provides a reusable template for human-aligned evaluation of agentic systems in scientific domains.

The DeepResearch Agent System is a large language model system engineered for deep information retrieval, multi-step reasoning, and autonomous research tasks. Built upon a sparse activation architecture with 30 billion total parameters of which only 3 billion are activated per token, the system achieves state-of-the-art performance on multiple agent search benchmarks while delivering 3.2 times faster inference compared to dense counterparts of equivalent scale. The system supports a 128K-token context window with hierarchical attention mechanisms that yield 18.7% accuracy and 23.4% recall improvements over standard long-context approaches. A dual-mode reasoning engine provides both a ReAct paradigm for basic multi-step problem solving and an IterResearch mode for high-performance iterative research with up to 20 reasoning steps, collectively delivering a 31.2% accuracy improvement over single-pass baselines. Multi-tool coordination integrates retrieval, computation, web search, and file parsing modules to achieve 92.1% tool-use accuracy. A reinforcement learning optimization framework based on the GRPO algorithm provides token-level policy gradients that improve training stability by 35% and accelerate convergence by 42%. An automated data synthesis pipeline with seed-based expansion achieves a 92.5% usability rate. Benchmark results include 87.3% on Humanity's Last Exam, 85.3% on BrowserComp Chinese, and 91.2% on WebWalkerQA. The system is fully open-sourced, including data synthesis, training, and inference code, and supports applications in academic research, business analysis, R&D support, and education.

Translational medicine turns underspecified development goals into evidence synthesis that must combine literature, trials, patents, and quantitative multi-omics analysis while preserving identifiers, uncertainty, and retrievable provenance. General-purpose foundation models and off-the-shelf tool-augmented or multi-agent systems are not built for this: they tend to produce single-shot answers or run open-endedly, and fall short on the auditable, scenario-specific workflows that heterogeneous biomedical sources demand. This paper introduces Ingenix BioResearcher, a scenario-guided multi-agent system that maps queries to versioned research playbooks, delegates to specialized subagents over 30+ tools and machine-learning endpoints, mixes structured database access with sandboxed code for genome-scale analyses, and applies claim-level multi-model reconciliation before editorial assembly. We evaluate BioResearcher across unit-level capabilities, open-ended biomedical reasoning, and end-to-end clinical discovery. It leads evaluated baselines on 109 single-step tests (83.49% pass rate; 0.892 average score), achieves strong biomedical benchmark performance (89.33% on BixBench-Verified-50 and the top 0.758 mean score on BaisBench Scientific Discovery), and leads on a 30-query clinical end-to-end benchmark with the highest positive hit rate (74.7% $\pm$ 3.3%) and negative clear rate (96.8% $\pm$ 0.2%). These results show broad, competitive performance across unit-level, open-ended, and end-to-end clinical evaluations.