The Exceedance Design Effect: Effective Sample Size for Thresholds under Clustering

Information systems (IS) researchers increasingly use quasi-experimental methods such as difference-in-differences (DiD) and instrumental variables (IV) to recover causal effects from observational panel data. Power calculations that justify these designs assume i.i.d. errors, but the deeper problem is what even a cluster-robust calculator cannot see. We report a Monte Carlo study over 9837 parameter conditions (approx 9.8 million datasets) and decompose the planned-versus-achieved power gap. The serial-correlation component is recoverable by an AR(1)-aware calculator when rho is known, and partially when rho must be estimated from short pre-periods, but panel attrition, staggered-adoption bias, and parallel-trends pretesting are captured by no closed-form formula; exogenous attrition alone costs approx 8 to 11 percentage points at the few-hundred-to-thousand sample sizes IS studies use. Treatment-correlated, outcome-dependent attrition instead induces bias, not just power loss. For IV, holding first-stage F fixed, larger N neither raises power nor curbs exclusion bias, though with a fixed instrument more data does sharpen the first stage, so identification rests on instrument strength, not sample size.

Effective sample size is a standard summary of Markov chain Monte Carlo output, but it is usually attached to scalar or Euclidean summaries chosen by the analyst. For manifold-valued samples this choice is not canonical: coordinate-wise effective sample sizes can change under rotations, chart changes, or alternative embeddings of the same underlying path. We propose an intrinsic effective sample size based on kernel discrepancy. The proposed quantity is the number of independent draws that would yield the same expected squared kernel discrepancy between the empirical distribution and the target distribution. This gives an exact finite-sample risk interpretation, an asymptotic integrated-autocorrelation representation, and a coordinate-free diagnostic whenever the kernel respects the geometry of the state space. We establish invariance under transported kernels, operator and principal-direction interpretations, and consistency of a lag-window estimator under boundedness and absolute-regularity conditions. We also discuss valid kernel constructions on manifolds, emphasizing that geodesic Gaussian kernels are not generally positive definite on curved spaces. Sphere experiments illustrate rotation invariance and calibration of the proposed diagnostic against empirical distributional error.

Random splitting can yield non-independent train--test subsets when a dataset contains related samples, as is common in certain applications such as biochemical studies. This leads to overly optimistic generalization estimates. Here, we introduce ReLaG, a modality-agnostic framework that models sample relatedness through a hierarchical latent-variable process and infers groups of related samples using proximity graphs and community detection to produce independent train--test subsets. Across molecular and protein datasets, ReLaG matches existing relation-aware methods while scaling substantially better, enabling splits at previously impractical dataset sizes. We further introduce a label-free procedure that adapts the splitting resolution to production data, aligning evaluation with the intended deployment setting. ReLaG's inferred groups provide a cheap estimate of effective dataset size, enabling diversity-aware dataset scaling. ReLaG is open source and can be installed with pip install relag.