Digital mobility outcomes (DMOs) derived from wearable sensors characterise mobility in daily life and offer a promising means of monitoring disease progression. However, existing DMO studies have typically focused on either a single disease or a single visit. To the best of our knowledge, this is the first study to systematically model and analyse longitudinal multivariate DMOs across diverse mobility-limiting diseases. Specifically, we propose DeMMO, an interpretable framework for longitudinal, multi-disease, and multi-outcome learning. DeMMO represents each disease--outcome objective using a longitudinal DMO coefficient matrix and combines temporal regularisation with stable and visit-specific feature selection. Its central technical contribution is an automatic cross-disease and cross-outcome relation-learning mechanism that infers signed relations directly from these longitudinal mappings, thereby enabling selective information sharing across cohorts without requiring paired participants. We evaluate DeMMO on the recently released, large-scale, multicentre Mobilise-D dataset, which comprises four participant-disjoint cohorts representing distinct mobility-limiting diseases, with each cohort contributing one or more clinical measurement outcomes. Compared with eight strong structural longitudinal and deep-regression baselines, DeMMO achieves the best overall predictive performance and outperforms the baselines for most individual outcomes. Stability selection further identifies reliable longitudinal DMO patterns that can inform subsequent clinical validation and disease monitoring. The implementation code is available at https://github.com/menghui-zhou/DeMMO.
Multimodal clinical learning is increasingly important for integrating diverse patient data, including imaging, text, and personalised health records. However, it faces two fundamental challenges: i) modality missingness, where arbitrary subsets of modalities are unavailable at a given patient visit, ii) longitudinal dynamics, where the diagnostic significance of an observation depends on the patient's evolving disease trajectory over time. Existing methods address these challenges in isolation: missing-modality frameworks treat each visit as an independent static snapshot and discard temporal context, while longitudinal models often assume complete modality availability and degrade under systematic modality incompleteness. We propose LongMoE (Longitudinal Mixture-of-Experts), the unified framework to jointly address both challenges. LongMoE combines a context-aware imputation module with an attentional tokenization module that captures frequency-domain temporal patterns across irregular visit sequences, a trajectory-aware encoder for modeling disease progression, and context-conditioned Sparse MoE routing for patient-specific expert selection. Experiments on ADNI, OASIS-3, and MIMIC-IV show that LongMoE improves robustness under missing or weak contemporaneous modalities and remains competitive in full-modality settings, establishing a strong foundation for longitudinally-aware multimodal clinical learning.
Maxx Richard Rahman, Prakhar Kumar, Wolfgang Maass
Wearable and mobile sensing technologies enable continuous monitoring of human behavior and health in real-world settings. However, predictive modeling in longitudinal multimodal data remains challenging, particularly when targeting complex or clinically derived outcomes. In this work, we present a longitudinal multimodal study of 66 older adults conducted in real-world conditions and combining wearable sensing, behavioral monitoring, and clinical assessments. This setting provides a rare opportunity to study an underrepresented population in long-term, into-the-wild conditions. Building on this dataset, we investigate how the alignment between sensed signals and target variables affects predictive performance across health-related tasks. We design a unified evaluation framework spanning tasks with increasing levels of observability, including Activity Levels prediction, Sleep Duration estimation, and Sleep Apnea Severity classification. Our results reveal a clear gradient of predictability: highly observable behavioral targets achieve robust performance (macro-F1 65%), while more abstract outcomes remain challenging despite consistent improvements over baseline models. Moreover, through explainability analysis, we show that historical features consistently emerge as the most informative predictors, highlighting the central role of longitudinal information.
Flavio Di Martino, Mattia G. Campana, Marcello Magno +2
Extracting informative representations from longitudinal data that can predict future outcomes remains a critical challenge in medicine. Medical datasets are inherently heterogeneous, consisting of a large number of variables collected from different sources, sampled with different temporal spacings, and representing different aspects of human health status. This requires identifying those variables with predictive value, processing longitudinal information, and integrating multiple variables for outcome prediction. Here, we propose a novel agent-based approach, LongAgent, that can autonomously search over combinations of variable sets, temporal windows and longitudinal aggregation functions, and identify candidates with promising predictive performance. LongAgent utilises a history memory of previous searches and numerical evidence to guide subsequent exploration. On synthetic data, LongAgent achieves a mean prediction RMSE of 1.7376 and improves over the strongest non-agent baseline by 0.0151 (95% CI: [0.0045,0.0260]; p=0.0273). On a real clinical dataset, it performs comparably to the best baseline.