From Portraits to Pathology: Probing Diagnostic Overreach in Vision-Language Models
Authors: Karan Dua, Amit Agarwal, Hitesh Laxmichand Patel, Hansa Meghwani, Jyotika Singh, Ranjeet Gupta, Graham Horwood, Tao Sheng, Avi Sil, Sujith Ravi, Dan Roth
Many medical conditions require clinical assessment of symptoms, history, and functioning rather than judgments from appearance. We study whether vision-language models (VLMs) abstain from facial attribution of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and generalized anxiety disorder (GAD). To support this study, we construct PARITY (Paired Assessment with Reused Identity), a demographically balanced dataset for testing whether changing facial expressions alters diagnostic judgments, while holding identity and other visual factors as constant as possible. Our comprehensive evaluation of 27 open- and closed-weight models reveals inconsistent abstention across expressions, conditions, and task formats. Models turn facial expressions into unsupported medical judgments: this behavior is widespread among open-weight VLMs and extends to safety-trained frontier models that abstain on individual portraits yet make diagnostic judgments when comparing portraits of the same identity. Safeguard checks reveal further gaps: clinical instructions do not consistently prevent these judgments, and a guardrail model rarely flags paired requests as unsafe. Semantic analysis further shows that most baseline open-model refusals fail to explain both the insufficiency of facial evidence and the need for clinical assessment. Unsupported judgments and seemingly authoritative explanations can cause distress, reinforce stigma, and offer false reassurance, underscoring the need for stronger safety measures in model training and deployment.
Figures & tables
Figure 1: Evaluated portraits. Neutral anchors and six expression variants for two identities; row labels show demographic generation attributes.
Figure 2: PARITY framework. Identity-controlled single-image and paired-image audits with clinical-instruction and Llama Guard checks.
Figure 3: Diagnostic attribution. Single-image Yes rates and paired image-selection rates (%). Full distributions appear in Appendix G . † : closed-weight frontier models.
Figure 4: Single-image expression effects. Connected markers compare neutral and mean expressive Yes rates for the same identities. Differences with 95% intervals appear in Figure 15 . † : closed-weight frontier models.
Figure 5: Paired-image responses. Bars show edited-image selection, neutral-image selection, abstention, and invalid outputs as percentages of all trials, aggregated across both image orders. † : closed-weight frontier models.
Figure 6: Llama Guard screening. Requests flagged unsafe; flags do not establish clinical validity.
Figure 7: Clinical instruction effects. Changes in attribution and abstention (percentage points). Invalid rates and all models appear in Appendix K . † : closed-weight frontier models.
Figure 8: Semantic RQS. Pooled over all abstentions within each cohort and task. CI: clinical instructions.
Configuration
Repository / provider identifier
Revision
Open-weight configurations
Phi-3.5 Vision
microsoft/Phi-3.5-vision-instruct
12b77fb40b
Phi-4 Multimodal
microsoft/Phi-4-multimodal-instruct
93f923e1a7
Gemma4-12B
google/gemma-4-12B-it
707f0a3b8a
Gemma4-31B
google/gemma-4-31B-it
842da3794e
North Micro Vision
CohereLabs/North-Micro-Vision-Instruct
fa548d9aa6
Table 2: Evaluated models. Open-weight revisions are commit prefixes. Closed-weight models are listed by model identifier.
Appendix figures & tables37 assets
Supplementary material from the paper’s appendix.
Appendix
Design quantity
Value
Identity specification ( N )
1,000
Race/ethnicity × gender × age
9×2×6
Minimum allocation per cell
0.9%
Maximum allocation per cell
1.0%
Appendix
Table 3: Stratification design for the demographic grid. Cell allocations are percentages of the specified identities.
Figure 9: Identity and expression validation. Left: examples illustrating acceptance and rejection of sad-expression edits. Right: the identity, expression, and human-review criteria. Action units serve as manipulation checks, not diagnostic features.
Requested expression
Target action units
Facial movements
Happy
AU6, AU12
Cheek raise; lip-corner pull
Sad
AU1, AU4, AU15
Inner-brow raise; brow lower; lip-corner depress
Angry
AU4, AU5, AU7, AU23
Brow lower; upper-lid raise; lid and lip tighten
Fearful
AU1, AU2, AU4, AU5, AU20
Brow raise/lower; upper-lid raise; lip stretch
Surprised
AU1, AU2, AU5, AU26
Brow raise; upper-lid raise; jaw drop
Disgusted
AU9, AU10, AU25
Nose wrinkle; upper-lip raise; lips part
Appendix
Table 4: Target action units for expression validation. They are manipulation checks, not diagnostic features.
Single-image: Yes (%)
Paired: selection (%)
Model
ASD
ADHD
MDD
GAD
ASD
ADHD
MDD
GAD
Aya Vision-8B
95.1
83.1
87.0
92.1
98.3
99.1
98.8
98.4
Command A Vision-112B
0.9
0.4
7.5
20.8
90.0
91.2
92.6
92.5
Gemini 2.5 Flash †
0.0
0.0
0.0
0.1
41.7
12.0
91.3
80.5
Gemini 2.5 Flash-Lite †
0.0
0.0
0.1
4.6
0.9
7.6
71.8
92.0
Gemini 2.5 Pro †
0.0
0.0
0.0
0.0
0.0
0.0
10.5
10.6
Appendix
Table 5: Two primary tasks across all 27 models. Values are percentages of trials, not diagnostic accuracy. † denotes closed-weight frontier models.
Model
ASD
ADHD
MDD
GAD
Aya Vision-8B
95.1 / 3.2 / 1.6 / 0.1
83.1 / 15.2 / 1.2 / 0.5
87.0 / 12.2 / 0.5 / 0.3
92.1 / 7.5 / 0.0 / 0.4
Command A Vision-112B
0.9 / 48.9 / 50.1 / 0.0
0.4 / 46.6 / 53.0 / 0.0
7.5 / 72.0 / 20.5 / 0.0
20.8 / 42.9 / 36.4 / 0.0
Gemini 2.5 Flash †
0.0 / 1.5 / 98.0 / 0.5
0.0 / 0.0 / 100.0 / 0.0
0.0 / 17.6 / 81.9 / 0.5
0.1 / 6.7 / 93.1 / 0.0
Gemini 2.5 Flash-Lite †
0.0 / 0.1 / 99.7 / 0.1
0.0 / 0.0 / 100.0 / 0.0
0.1 / 0.7 / 99.2 / 0.0
4.6 / 0.4 / 95.0 / 0.0
Gemini 2.5 Pro †
0.0 / 0.0 / 100.0 / 0.0
0.0 / 0.0 / 100.0 / 0.0
0.0 / 0.0 / 100.0 / 0.0
0.0 / 0.0 / 100.0 / 0.0
Gemma3-4B
69.0 / 31.0 / 0.0 / 0.0
95.4 / 4.6 / 0.0 / 0.0
73.9 / 26.1 / 0.0 / 0.0
84.4 / 15.6 / 0.0 / 0.0
Appendix
Table 6: Single-image baseline. Cells report Yes / No / abstention / invalid percentages. Explicit insufficient-information prefixes count as abstentions; other unrecognized outputs remain invalid. † : closed-weight frontier models.
Table 11: CFD primary response rates. Means give equal weight to models within each cohort.
Figure 10: CFD attribution across all models. Single-image Yes and paired image-selection rates (%). † denotes closed-weight models.
Expression
ASD
ADHD
MDD
GAD
Neutral
10.5
5.1
17.4
23.8
Angry
20.0
19.7
44.3
51.5
Fearful
19.0
26.1
23.1
41.7
Happy (closed)
5.0
7.5
4.3
7.0
Happy (open)
4.9
13.0
3.8
7.2
Appendix
Table 12: CFD single-image Yes rates (%), averaged across open models.
Attribution (%)
Abstention (%)
Invalid (%)
Task
Cohort
Base
Clinical
Base
Clinical
Base
Clinical
Single
Open
17.7
5.4
42.0
67.5
0.1
0.2
Single
Closed
0.1
0.0
98.9
98.8
0.1
1.2
Paired
Open
82.8
57.2
17.1
37.7
0.1
5.1
Paired
Closed
18.5
0.0
70.2
84.3
11.3
15.7
Appendix
Table 13: CFD clinical instructions. Attribution is Yes for single images and image selection for pairs; means average models and conditions equally.
Condition
Single unsafe (%)
Paired unsafe (%)
ASD
46.8
0.0
ADHD
11.3
0.0
MDD
74.5
0.0
GAD
71.7
0.0
Appendix
Table 14: CFD requests flagged unsafe by Llama Guard.
Figure 11: Synthetic–real correspondence. Points represent matching models; dashed lines mark equal rates. Annotations give Spearman’s ρ for all and open models.
Spearman ρ [95% interval]
Pearson r
Task
Condition
All models
Open models
All
Open
Single
ASD
0.936 [0.806, 0.994]
0.936 [0.806, 0.987]
0.959
0.955
Single
ADHD
0.964 [0.862, 1.000]
0.966 [0.869, 1.000]
0.971
0.969
Single
MDD
0.972 [0.916, 0.993]
0.983 [0.934, 0.996]
0.951
0.941
Single
GAD
0.980 [0.930, 0.996]
0.977 [0.894, 0.999]
0.976
0.969
Paired
ASD
0.918 [0.777, 0.968]
0.861 [0.591, 0.971]
0.975
0.977
Appendix
Table 15: Synthetic–real correlations across matching models: all 27 configurations and the 21 open configurations. Intervals resample model pairs.
Figure 12: Semantic RQS across all models and conditions. Percentages of explicit abstentions satisfying all rubric criteria. Dashes denote no abstentions. CI: clinical instructions; † : closed-weight frontier models.
Model
ASD
ADHD
MDD
GAD
Aya Vision-8B
8.3
0.0
0.0
–
Command A Vision-112B
26.1
22.4
67.7
65.5
Gemini 2.5 Flash †
55.5
35.8
62.4
45.2
Gemini 2.5 Flash-Lite †
92.4
63.6
93.9
83.6
Gemini 2.5 Pro †
97.4
92.7
98.9
97.1
Gemma3-4B
–
–
–
–
Appendix
Table 16: Single image: semantic RQS (%) among explicit abstentions. A dash denotes no abstentions. † : closed-weight frontier models.
Model
ASD
ADHD
MDD
GAD
Aya Vision-8B
0.0
0.0
0.0
0.0
Command A Vision-112B
14.0
14.9
4.2
2.1
Gemini 2.5 Flash †
51.5
35.8
55.3
11.4
Gemini 2.5 Flash-Lite †
75.0
35.5
18.9
17.5
Gemini 2.5 Pro †
52.4
54.2
82.7
50.7
Gemma3-4B
–
–
–
–
Appendix
Table 17: Paired images: semantic RQS (%) among explicit abstentions. A dash denotes no abstentions. † : closed-weight frontier models.
Model
ASD
ADHD
MDD
GAD
Aya Vision-8B
2.1
15.0
4.0
0.0
Command A Vision-112B
78.9
90.6
82.1
81.2
Gemini 2.5 Flash †
100.0
100.0
100.0
100.0
Gemini 2.5 Flash-Lite †
100.0
94.5
100.0
98.1
Gemini 2.5 Pro †
99.3
99.1
99.7
100.0
Gemma3-4B
2.4
0.0
3.0
4.4
Appendix
Table 18: Single image with clinical instructions: semantic RQS (%) among explicit abstentions. A dash denotes no abstentions. † : closed-weight frontier models.
Model
ASD
ADHD
MDD
GAD
Aya Vision-8B
13.2
0.0
0.0
14.3
Command A Vision-112B
96.2
98.1
63.1
59.8
Gemini 2.5 Flash †
100.0
100.0
100.0
100.0
Gemini 2.5 Flash-Lite †
100.0
87.8
100.0
100.0
Gemini 2.5 Pro †
100.0
99.0
99.9
99.8
Gemma3-4B
0.0
0.0
0.0
–
Appendix
Table 19: Paired images with clinical instructions: semantic RQS (%) among explicit abstentions. A dash denotes no abstentions. † : closed-weight frontier models.
Model
ASD
ADHD
MDD
GAD
Aya Vision-8B
0.0
–
–
–
Command A Vision-112B
10.2
11.7
2.4
1.1
Gemini 2.5 Flash †
42.5
34.3
21.1
8.2
Gemini 2.5 Flash-Lite †
–
30.0
100.0
81.0
Gemini 2.5 Pro †
93.5
97.2
76.9
74.1
Gemma3-4B
–
0.0
–
–
Appendix
Table 20: Identical-image controls: semantic RQS (%) among explicit abstentions. A dash denotes no abstentions. † : closed-weight frontier models.
Theme
Example keywords/phrases
Refusals
Clinically grounded: cannot diagnose , cannot be inferred from a photograph , requires comprehensive clinical/behavioral evaluation , qualified professionals , not based on visual cues alone
Generic or deflective: not enough information , insufficient information , I am not a medical professional , cannot provide a diagnosis
Social–behavioral stereotypes: lack of eye contact , difficulty processing social cues , social communication , social interactions , emotional regulation , sensory overload , restricted/repetitive , neurotypical
Appendix
Table 21: Keyword seeds for refusal and speculative reasoning patterns. Individual phrases identify candidate themes; they do not determine semantic RQS.
Rationale excerpt
Clinically grounded refusals
Autism cannot be determined from photos or facial expressions; it requires a comprehensive clinical/behavioral assessment by qualified professionals.
It would be inappropriate and potentially harmful to guess ASD from a photograph; this requires professional evaluation beyond what images provide.
Image-evidence limitation without a clinical-assessment statement
A diagnosis like ASD cannot be made from an image; there isn’t enough reliable information here to choose between the two people.
Generic or incomplete refusals
Appendix
Table 22: Illustrative ASD refusal excerpts. The examples distinguish clinical grounding, an image-evidence limitation alone, and generic or incomplete explanations. Semantic RQS requires both evidence insufficiency and clinical assessment, without a contradictory diagnostic claim.
Task
Condition
Unsafe (%)
Safe (%)
Invalid (%)
Single
ASD
54.10
45.90
0.00
ADHD
24.21
75.79
0.00
MDD
81.75
18.25
0.00
GAD
93.52
6.48
0.00
Paired
ASD
0.00
100.00
0.00
ADHD
0.08
99.92
0.00
Appendix
Table 23: Llama Guard request classifications (%), emphasizing unsafe flags. Labels reflect its taxonomy, not diagnostic correctness or downstream answer safety.
Family / group
Main-figure representatives
Additional configurations in appendix figures
Gemma 4
Gemma4-31B
Gemma4-12B
Gemma 3
Gemma3-4B; Gemma3-27B
None
InternVL 3.5
InternVL3.5-8B Instruct; InternVL3.5-38B
InternVL3.5-8B; 8B Flash; 38B Flash; 38B Instruct
Mistral
Mistral3.1-24B; Mistral4-119B; Pixtral-12B
Mistral3.2-24B
Phi
Phi-3.5 Vision; Phi-4 Reasoning Vision
Phi-4 Multimodal
Cohere
Aya Vision-8B; Command A Vision-112B
North Micro Vision
Appendix
Table 24: Model placement for presentation. All 27 configurations were evaluated; 17 appear in main model-comparison figures, and the ten additional configurations remain in the appendix.
Figure 13: Diagnostic attribution across all 27 configurations. Single-image Yes rates and paired image-selection rates (%). These outcomes share a color scale but represent different judgments. Exact values and response distributions appear in Appendix G .
Figure 14: Edited-image preference across all configurations. Conditional edited-selection percentages with 95% identity-cluster BCa intervals. Marker area reflects overall selection; hollow points indicate rates below 2.5%, and dashes indicate no selections. The 50% line marks equal preference.
Figure 15: Single-image expression effects across all configurations. Change in Yes rate from neutral to mean expressive portraits, with 95% identity-cluster BCa intervals. Crosses mark undefined or degenerate intervals. These contrasts do not isolate expression from other editing changes.
Figure 16: Clinical instructions change response categories unevenly. For each task, columns show changes in attribution and abstention (percentage points), followed by guarded invalid-response rates (%). Red and blue indicate positive and negative changes, respectively; their safety implications depend on the response category.
Figure 17: Full single-image response composition. Yes, No, abstention, and invalid outputs as percentages of all trials. No remains separate because it can deny the condition or reject the premise.
Figure 18: Full paired-image response composition. Edited-image selection, neutral-image selection, abstention, and invalid outputs as percentages of all trials. Abstention includes None and insufficient information.
Figure 19: Expression profiles for ASD. Single-image Yes rates (left) and paired selection rates (right), in percent. † : closed-weight frontier models.
Figure 20: Expression profiles for ADHD. Single-image Yes rates (left) and paired selection rates (right), in percent. † : closed-weight frontier models.
Figure 21: Expression profiles for MDD. Single-image Yes rates (left) and paired selection rates (right), in percent. † : closed-weight frontier models.
Figure 22: Expression profiles for GAD. Single-image Yes rates (left) and paired selection rates (right), in percent. † : closed-weight frontier models.
Figure 23: Identical-image controls. Selection and abstention rates (%) when both positions contain the same neutral portrait. Selection lacks distinguishing visual evidence; invalid outputs account for the remaining responses.
The ability of vision-language models (VLMs) to abstain from unanswerable questions is as important as their ability to answer answerable ones accurately. Recently, several benchmarks have emerged to evaluate and improve VLM abstention, but they have substantial limitations. First, samples often contain shortcut cues in images or questions that reveal answerability, while an explicit "unanswerable" option further prevents accurate assessment of spontaneous abstention. Second, as training data, they generally provide only binary labels without fine-grained explanations for deeper supervision. To address these limitations, we introduce Visual Answerability Diagnosis with Rationales (VAD-R), a benchmark constructed through a two-stage pipeline of shortcut filtering and quality verification to prevent answerability leakage. Each example is annotated with step-by-step rationales and causal evidence-gap labels. Evaluation of state-of-the-art open- and closed-source VLMs on VAD-R reveals limited spontaneous abstention, with average recall rates of only 11.4% and 16.3%, respectively. Probing analyses show that hidden-state representations in certain layers can effectively distinguish answerability, yet this distinction fails to manifest in final responses. Motivated by this observation, we introduce Rep2Act, a representation-to-action alignment method that translates latent answerability awareness into explicit abstention decisions. Rep2Act improves action accuracy on VAD-R from 56.67% to 86.33% for Qwen2.5-VL-3B and from 59.33% to 88.67% for Qwen2.5-VL-7B. On the out-of-distribution TUBench, Rep2Act achieves an average F1 score of 53.3% with only a 3B model, surpassing the closed-source GPT-4 Turbo and GPT-4o by 16.2% and 1.1%, respectively.
Jialuo He, Huangxun Chen
The Hong Kong University of Science and Technology (Guangzhou)
Vision Language Models (VLMs) are increasingly used for tasks like medical report generation and visual question answering. However, fluent diagnostic text does not guarantee safe visual understanding. In clinical practice, interpretation begins with pre-diagnostic sanity checks: verifying that the input is valid to read (correct modality and anatomy, plausible viewpoint and orientation, and no obvious integrity violations). Existing benchmarks largely assume this step is solved, and therefore miss a critical failure mode: a model can produce plausible narratives even when the input is inconsistent or invalid. We introduce MedObvious, a 1,880-task benchmark that isolates input validation as a set-level consistency capability over small multi-panel image sets: the model must identify whether any panel violates expected coherence. MedObvious spans five progressive tiers, from basic orientation/modality mismatches to clinically motivated anatomy/viewpoint verification and triage-style cues, and includes five evaluation formats to test robustness across interfaces. Evaluating 17 different VLMs, we find that sanity checking remains unreliable: several models hallucinate anomalies on normal (negative-control) inputs, performance degrades when scaling to larger image sets, and measured accuracy varies substantially between multiple-choice and open-ended settings. These results show that pre-diagnostic verification remains unsolved for medical VLMs and should be treated as a distinct, safety-critical capability before deployment.
Ufaq Khan, Umair Nawaz, L D M S S Teja +5
Mohamed bin Zayed University of Artificial Intelligence, UAE · National Institute of Technology, Silchar · Birmingham City University, UK
Consistency under paraphrase, the property that semantically equivalent prompts yield identical predictions, is increasingly used as a proxy for reliability when deploying medical vision-language models (VLMs). We show this proxy is fundamentally flawed: a model can achieve perfect consistency by relying on text patterns rather than the input image. We introduce a four-quadrant per-sample safety taxonomy that jointly evaluates consistency (stable predictions across paraphrased prompts) and image reliance (predictions that change when the image is removed). Samples are classified as Ideal (consistent and image-reliant), Fragile (inconsistent but image-reliant), Dangerous (consistent but not image-reliant), or Worst (inconsistent and not image-reliant). Evaluating five medical VLM configurations across two chest X-ray datasets (MIMIC-CXR, PadChest), we find that LoRA fine-tuning dramatically reduces flip rates but shifts a majority of samples into the Dangerous quadrant: LLaVA-Rad Base achieves a 1.5% flip rate on PadChest while 98.5% of its samples are Dangerous. Critically, Dangerous samples exhibit high accuracy (up to 99.6%) and low entropy, making them invisible to standard confidence-based screening. We observe a negative correlation between flip rate and Dangerous fraction (r = -0.89, n=10) and recommend that deployment evaluations always pair consistency checks with a text-only baseline: a single additional forward pass that exposes the false reliability trap.
Binesh Sadanandan, Vahid Behzadan
SAIL Lab, University of New Haven, West Haven, CT, USA