Involving before Evolving: A Vision for Trustworthy Enterprise Digital Twin Engineering

As Digital Twin (DT) systems evolve beyond state synchronization toward task-oriented and knowledge-driven operation, Cognitive Digital Twins (CDTs) have emerged as an extension that incorporates cognitive capabilities into twin operation. Existing CDT studies often focus on specific enabling techniques, such as learning modules, knowledge graphs, and large language models, while providing limited insight into how cognition can be systematically integrated into DT architectures. To address this issue, this paper proposes a four-layer CDT architecture consisting of the physical layer, digital-twin layer, cognitive layer, and task layer. The proposed architecture establishes a self-evolving closed operational loop spanning these four layers, in which physical states are synchronized into digital representations, cognition constructs task-specific cognitive models through knowledge, memory, and attention, and task-level decisions are generated under practical constraints. Operational feedback further refines cognitive experience and updates relationships and annotations in the digital representation, enabling subsequent task interpretation, initiation, and reasoning to evolve with system operation. Based on this framework, two representative operation modes are characterized: user-request-driven cognition and self-driven cognition. We further discuss key enabling mechanisms and deployment challenges associated with semantic communication, knowledge querying, task orchestration, and closed-loop synchronization. A lightweight simulation study illustrates reliable closed-loop task feasibility under limited semantic information and improved operational efficiency through accumulated task experience. The proposed framework provides a structured foundation for the design and development of future CDT systems.

AI agents increasingly gather evidence, invoke tools, apply constraints, and produce decisions that people or software may commit to action. A final output alone cannot show which evidence, tool state, rule, authorization, or action path produced it. We present DNative-Twin, a graph-native digital twin that records a committed agentic decision as a typed trajectory and re-executes its decision mechanism under declared conditions. The graph links the state observed by the agent, the path it followed, and the authority behind the resulting action. The twin synchronizes this information, replays the mechanism in isolation, and compares it under controlled changes. We instantiate the framework in enterprise decision processes using three public process logs and controlled replay suites. The experiments identify a specific failure: graph structure localizes represented changes but cannot determine the consequence of an unobserved tool state. In a three-condition controlled experiment with 300 injected instances, unresolved-divergence recall increased from 0 to 0.667 when replay-contract state was added and to 1.0 when verification results were also available; the held-out set contained no critical-class instance. Across 500--5,000 BPI 2020 cases, median end-to-end time increased from 0.794 to 8.889 seconds on the reported platform. These results separate the roles of graph structure, replay context, and verification evidence in reviewing a decision mechanism.

Health digital twins (HDTs) promise patient-specific modeling and decision support but current approaches remain structurally fragmented: monolithic models that address a single organ or task lack cross-scale fidelity, while system-level twins lack generalizable architectural frameworks. We propose OmniBioTwin, a System-of-Twinned-Systems (SoTS) framework that organizes HDTs as modular computational entities coupled through explicit interaction operators within a multi-layer network architecture. The framework comprises seven coordinated layers - spanning data integration, autonomous twin modeling, cross-scale coupling, temporal synchronization, and human-in-the-loop decision support. We demonstrate OmniBioTwin by instantiating a multiscale twin for glucagon-like peptide-1 (GLP-1) signaling pathways in Alzheimer's disease, illustrating how molecular, cellular, and organ-level twins can be composed and coupled within a unified system.