X-ray coronary angiography is the clinical gold standard for coronary artery disease during real-time cardiac interventions, but provides only 2D projections of inherently 3D vessels. Existing learning-based 2D-to-3D reconstruction methods typically require wide angular coverage or multiple views, assumptions that are rarely satisfied in routine practice where only two projections with narrow angular separation are available. To address these challenges, we propose NeCA++, a multi-stage self-supervised neural radiance field (NeRF) framework tailored to clinically realistic acquisition constraints. The framework decomposes reconstruction into two stages that progressively refine spatial support and representation capacity. In the first stage, a coarse 3D representation of the vasculature is reconstructed, restricting the subsequent optimisation to regions with a higher likelihood of vessel presence, termed an active region. Afterward reconstruction is restricted to this region while higher-resolution representations are progressively activated to recover fine vascular details. This multi-stage strategy focuses learning on anatomically plausible regions, mitigates gradient dilution under extreme sparsity, and stabilises global topology before recovering fine vascular branches. Furthermore, two vessel-specific regularisations are introduced: a ray-aligned constraint to reduce projection-induced ambiguity, and a bimodal density penalty to enable early vessel-background separation. Extensive experiments across three datasets (ImageCAS, ASOCA, and Synthetic RCA) and four angular configurations demonstrate consistent superiority over state-of-the-art baselines, particularly under clinically realistic narrow-angle settings, while achieving reconstruction within 58 seconds per case.
Multi-view reasoning in coronary X-ray angiography is inherently a cross-projection geometric problem, yet automated report generation in this setting remains largely unexplored. The 3D vascular topology leads to projection-dependent branch overlap and foreshortening, rendering single-view modeling fundamentally incomplete and unstable for lesion localization and stenosis grading. Although multi-view fusion appears promising, learning anatomically consistent fusion from real angiograms is impeded by a critical limitation: cross-view alignment is unobservable and cannot be explicitly supervised. Consequently, conventional fusion relies on implicit correlations rather than verified anatomical correspondence. We address this by reformulating multi-view stenosis reporting as an alignment-constrained aggregation problem. A controllable synthetic angiography generation strategy is introduced to expose geometry-derived patch-level correspondence supervision unavailable in real data. An anatomy-correspondence module learns cross-view correspondence matrices that explicitly align auxiliary features within the main-view coordinate space prior to fusion, thereby constraining evidence aggregation to anatomically consistent regions. Experiments on synthetic data and zero-shot transfer to real angiograms show that this alignment-constrained design improves correspondence consistency and structured stenosis reporting compared to single-view modeling and conventional multi-view fusion methods. The code will be publicly available upon publication.
Accurate correspondence matching across multiple angiographic views is the prerequisite for 3D coronary reconstruction and interventional guidance. However, the development of robust deep learning models for this task has been stifled by a fundamental data bottleneck. Obtaining ground truth for matching tasks in angiography pairs is prohibitively expensive and hard to scale. To overcome this barrier, we introduce a physically-grounded data generation framework that synthesizes high-fidelity Digital Reconstructed Radiographs (DRRs) from 3D Coronary CT Angiography (CCTA) volumes. Our framework generates dense, highly accurate 3D-to-2D projection labels by simulating realistic C-arm acquisition geometry on patient anatomy at zero human cost. Leveraging this dense supervision, we propose a Geometry-Informed Matching Module (GIMM) that integrates global feature and anatomical structure into correspondence learning. Unlike real angiography where assessment relies on subjective human annotation, our dataset provides 2D correspondence labels with paired images, allowing human-free evaluation. We comprehensively evaluate our method on the proposed CT-derived DRR dataset and demonstrate improvements over other matching baseline models.
Digital Subtraction Angiography (DSA) is one of the gold standards for vascular disease diagnosis. With the help of a contrast agent, time-resolved 2D DSA images deliver comprehensive blood flow information and can be utilized to reconstruct 3D vessel structures for medical assessment. Current commercial DSA systems typically require hundreds of scanning views to perform reconstruction, resulting in substantial radiation exposure. In this study, we propose a neural rendering-based optimization framework tailored for high-quality sparse-view DSA reconstruction to reduce radiation dosage. Our approach, termed vessel probability guided attenuation learning, represents DSA imaging as a complementary weighted combination of static and dynamic attenuation fields, with the weights derived from the time-independent vessel probability field. Functioning as a foreground mask, vessel probability provides proper gradients for both static and dynamic fields adaptive to different scene types. This mechanism enables self-supervised decomposition between static backgrounds and dynamic contrast agent flow, and significantly improves reconstruction quality. Our model is trained by minimizing the discrepancy between synthesized projections and real captured DSA images. We further employ two training strategies to improve reconstruction quality: (1) coarse-to-fine progressive training for better geometry and (2) temporal perturbed rendering loss for temporal consistency. Experimental results have demonstrated high-quality 3D vessel reconstruction and 2D DSA image synthesis.