Automating biological research requires general-purpose, reproducible robot systems that allow individual wet-lab researchers to delegate robot tasks without performing teleoperation or neural-network training. Vision-language-action policies have been proposed for general-purpose arms, but can lose performance when their operating environment changes. We therefore built WetRobo, a robot kit that can readily transfer between laboratories. It consists of one robot arm, laboratory equipment (an incubator, a reagent bottle with a cap, and a Petri dish), the existing code that moves the arm, teleoperation demonstrations of each task that we recorded, and a general AGENTS.md skill file. A biological experimentalist provides natural-language tasks without collecting local teleoperation training data or training a neural network. The coding agent observes the local laboratory and writes and executes programs, using external tools as needed for adaptation. We demonstrate use of WetRobo with OpenAI Codex (gpt-5.6-sol) on three successful tasks: lifting a Petri dish lid, removing a bottle cap, and opening the incubator door, all in real-world laboratories. The coding agent achieved the cap task in both laboratories, Lab X and Lab Y, whereas a VLA fine-tuned on Lab X demonstrations succeeded there but failed to transfer to Lab Y. These results point to a practical route for laboratory robotics: instead of training a policy for each laboratory, distribute a kit and let a coding agent adapt it in each laboratory. Code, demonstrations, and the evolved programs are available at https://github.com/tsudalab/WetRobo.
Biological wet-lab protocols are written for trained researchers and often leave routine operations, state-dependent conditions, and contextual parameters implicit, making them difficult to translate into robot-executable actions. We present ProtoAct, a structured protocol-grounding framework that converts free-form biological procedures into state-aware, embodiment-ready action sequences. ProtoAct uses ProtoRAG to retrieve manually annotated examples for context-sensitive parsing, employs RefineChecker to detect and revise missing or inconsistent steps, and applies ActSchema to map the refined procedure into constrained JSON function sequences. We further introduce BioP2E, for which we manually annotate 22 cell-culture protocols into 258 monitoring conditions, 910 executable subtasks, and 962 grounded action calls. Evaluation across seven large language models demonstrates that ProtoAct can be effectively instantiated with different backbones. Ablations confirm that retrieval, posterior checking, and schema constraints make complementary contributions. The parsed subtasks further support demonstration collection and VLA model training, enabling successful execution in both simulation and real-robot settings. ProtoAct thus provides a practical interface between biological protocol understanding and embodied robotic execution.
Today, progress in open-weight language models enables systems capable of writing, executing and debugging code while still running on a single workstation. Most language-driven robots give the model a fixed action interface or a trained policy. Generalizing to a new task therefore means more engineering effort or more data collection, both time-consuming. We investigate whether a local open-weight vision-language model can control a robot and one-shot generalize to new variations of a task without new human programming or training. We let a local open-weight VLM, Qwen3.8-27B, drive a UR3e robotic arm from a coding-agent harness. It writes and runs its own code above a service that implements kinematics, safety limits and classic computer vision techniques. We investigate if this system is capable of generalizing to unseen tasks. Specifically, we test it on nine tasks built from children's toys designed to probe generalization capability across various object characteristics: color, size, shape, and task variation of those. With five trials for each task, we observe generalization in 30 out of 45 trials with durations ranging from 3.4 to 67.5 minutes depending on task complexity. We further test if there is a speedup when an agent is asked to redo the task after successful completion. This resulted in a 50% reduction in duration, indicating that there is self-improvement over time. Finally, we expose the limitations of a local coding agent. We believe that solving those limitations combined with further investigation of self-improvement over time points at a direct path toward real-world deployment of a local coding agent.
Robot learning research is fragmented across policy families, benchmark suites, and real robots; each implementation is entangled with the others in a complex combination matrix, making it an engineering nightmare to port any single element. General-purpose coding agents may occasionally bridge specific setups, but cannot close this gap at scale because they lack the procedural priors and validation practices that characterize robotics research workflows. We propose NAUTILUS, an open-source harness that turns a single user prompt -- for example, "Evaluate policy A with benchmark B" -- into ready-to-use reproduction, evaluation, fine-tuning, and deployment workflows. NAUTILUS provides: plug-and-play agent skill sets with distilled priors from robotics research; typed contracts among policies, simulators/benchmarks, and real-world robots; unified interfaces and execution environments; and a trustworthy agentic coding workflow with explicit, automated validation, and testing at each milestone. NAUTILUS can not only automatically generate the required adapters and containers for existing implementations, but also wrap and onboard new or user-provided policies, simulators/benchmarks, and robots, all connected via a uniform interface. This expands cross-validation coverage without hand-written glue code. Like a nautilus shell that grows by adding chambers, NAUTILUS scales by extending its execution in chambered units, making it a research harness for scalability rather than a hand-curated framework, and aiming to reduce the engineering burden of cross-family reproduction and evaluation in the ever-growing robot learning ecosystem.