Field-of-View Extension in Dental Cone-Beam CT via Implicit Neural Representations and Diffusion Model-Based Refinement

Cone-beam computed tomography (CBCT) frequently suffers from data truncation, which introduces severe artifacts and limits the effective field of view (FOV). Existing deep learning methods for truncated cone-beam computed tomography (CBCT) reconstruction suffer from serious limitations, including a strict reliance on supervised ground truth and a failure to account for continuous 3D spatial truncation variations. To address these challenges, we introduce a self-supervised 3D reconstruction framework based on neural scene representations. By directly mapping spatial coordinates to radiodensity under projection supervision, our approach inherently bypasses traditional filtering and backprojection operations, thereby fundamentally eliminating truncation-induced ring artifacts while enabling robust continuous 3D data extrapolation. However, coordinate networks are susceptible to an inherent spectral bias, which leads to a severe loss of clinically vital high-frequency textures. To resolve this bottleneck, we further incorporate a physics-based iterative refinement module into the neural scene representation architecture. Leveraging the artifact-free, extrapolated volume from the coordinate network as an optimal initialization, this module progressively re-extracts and injects high-frequency structural information from the original projections back into the volume. Extensive experiments on both simulated and real-world datasets demonstrate that our method successfully unifies the exceptional artifact suppression and extrapolation capabilities of neural networks with the high-fidelity detail preservation of iterative algorithms.

The goal of this work is to reduce the effect of photon noise in dental cone-beam CT reconstruction. We consider an inverse problem formulation and develop a databased prior. To this end, we simulate fan-beam acquisitions and add photon noise to the projection data. The prior is obtained by training a gradient-step denoiser using reconstructed simulated acquisitions. The trained model is integrated into a plug-and-play gradient-step algorithm to reconstruct images from simulated projections. Experiments on synthetic data demonstrate the denoising capabilities of the trained model, while qualitative evaluations on real images showcase the algorithm's performance and generalization ability.

Cone-beam CT (CBCT) is routinely acquired during radiotherapy for patient setup, but its quantitative reliability is degraded by scatter, noise, and reconstruction artifacts, limiting Hounsfield Unit (HU) accuracy. We propose EPC-3D-Diff, a novel conditional 3D latent diffusion framework for volumetric CBCT to CT synthesis that introduces a projection domain equivariance loss derived from acquisition physics. Unlike common image domain equivariance, we exploit the fact that an in plane rotation of the volume corresponds to an angular shift in its projections. During training, we enforce this relationship by forward projecting rotated synthesized CT volumes and matching them to appropriately angle shifted projections of the paired target CT, yielding a physics consistent equivariance constraint integrated into the diffusion objective. To capture full 3D context efficiently, conditional diffusion is performed in a compact latent space learnt by a lightweight 3D autoencoder, preserving axial depth while downsampling in plane resolution for stable training. We validate on a paired head CBCT/CT phantom dataset, including repeat scans, and paired clinical data using patient wise splits, and perform single and mixed domain training, ablations, and comparisons with diffusion and CycleGAN. EPC-3D-Diff generalizes well and achieved substantial improvements, +7.4 dB (phantom) and +1.8 dB (clinical data) in PSNR compared to state of the art methods, alongside improved SSIM and HU accuracy, within tissue boundaries. Overall, EPC-3D-Diff improves robustness and physics consistency, supporting HU aware synthesis for downstream radiotherapy workflows. The open source code for EPC-3D-Diff is available at https://github.com/ALZAHRAALTALIB/EPC-3D-Diff.