CG-HAF: An Interpretable Global-Local Lesion-Burden Fusion Framework for Ordinal Acne Severity Grading in Agentic Skincare Support

Automated acne severity grading requires both whole-face context and fine-grained lesion evidence. We propose LENS-GRF (Lesion Evidence Network with Set-Transformer and Gated Residual Fusion), an interpretable multi-stage framework for four-class acne severity grading. The method combines Adaptive Facial Skin Segmentation and a global Vision Transformer prior with a permutation-invariant Lesion Set Transformer that encodes localized lesion patches and spatial geometry. Gated Residual Fusion adaptively controls the local residual contribution and reduces to the global prediction when the gate is zero. On ACNE04, fully automated LENS-GRF with YOLOv11s achieved 80.82% accuracy; with ground-truth lesion annotations, it achieved 95.89% +/- 0.59% accuracy and a Quadratic Weighted Kappa of 0.9753. A data-integrity audit identified 15 cross-split duplicate image pairs, including five with conflicting severity labels. In locked zero-shot evaluation on the full PLSBRACNE01 cohort (200 subjects, 600 views), automated LENS-GRF achieved 35.00% accuracy versus 42.50% for the global baseline. On the 148-subject common cohort used for three-dermatologist oracle analysis, ground-truth lesion inputs increased the best oracle accuracy to 47.97%, while the highest oracle QWK was 0.5799. Pairwise oracle agreement ranged from 49.32% to 66.22%, highlighting detector domain shift, annotation variability, and cross-criterion mismatch.

Acne vulgaris affects most adolescents and many adults. Accurate severity grading guides treatment, monitoring, and clinical trial endpoints, but manual assessment using the Investigator's Global Assessment or Hayashi criteria is limited by inter-rater variability and inconsistent imaging conditions. We developed a four-class acne severity classifier based on the Hayashi criteria using transfer learning with an ImageNet-pretrained EfficientNet-B0 model. The model was fine-tuned on the public ACNE04 dataset of 2,983 labeled images using AdamW optimization, geometric and photometric augmentation, and checkpoint selection based on validation macro-F1. On a held-out stratified 15 percent test set, the classifier achieved 93.5 percent accuracy and 94.4 percent macro-F1, with per-class F1 scores from 0.92 to 0.97. Eighty-three percent of errors occurred between adjacent grades. Quadratic-weighted Cohen's kappa was 0.956, with a 95 percent confidence interval of 0.935 to 0.973. Bootstrap confidence intervals indicated stable performance. Grad-CAM visualizations from the final convolutional block focused on clinically relevant facial regions, including the forehead, cheeks, and chin. The complete pipeline is provided as functionally equivalent open-source implementations in Python using PyTorch and timm, and in MATLAB R2026a. The software includes a clinician-facing inference interface and a fallback backbone option that supports operation without specialized pretrained-weight packages. These results show that lightweight transfer learning can provide accurate, balanced, and interpretable acne severity grading while offering a reproducible cross-platform reference for future prospective and device-stratified clinical validation.

Acne assessment is crucial for clinical decision-making, yet traditional grading and counting are subjective and fail to account for lesion size. While area-based assessment has emerged as a promising alternative, acne segmentation has continued to rely on general-purpose architectures. To address this gap, we propose VL-AcneSeg, a multimodal framework for acne lesion segmentation that leverages CLIP and region-level text prompts to incorporate spatial priors, enabling lesions to be localized across the whole face. Because region-level prompts indicate which facial areas contain lesions, we report a single global prompt, which requires no such information, as our primary setting. On our internal clinical dataset, VL-AcneSeg achieves a Dice score of 0.5082 and an IoU of 0.3407 under this protocol, the highest among all compared methods, including recent vision-language segmentation methods that are themselves given region-level prompts; region-level prompting raises these to 0.5296 and 0.3602. Moreover, lesion area measurements derived from our segmentation correlate with IGA scores at a level comparable to expert annotations (Pearson r = 0.719 versus 0.658). Notably, our framework maintains consistent performance across external validation datasets, performing reliably even on uncontrolled smartphone images without requiring additional training or fine-tuning. By pairing a protocol that requires no lesion-location information with area-based severity estimation, this work provides a foundation for objective acne assessment outside the clinic. Our implementation is publicly available at: https://github.com/sukjuoh/VL-AcneSeg