Codebook-Guided Cross-Modal Knowledge Distillation for Structurally Heterogeneous Features

Cross-modal knowledge distillation (CMKD) studies how a (large) teacher model trained on one type of data (e.g., images) can guide a (smaller) student model building on another type of data (e.g., text/audio). Existing CMKD methods often require paired multi-modal data with aligned semantics, but obtaining such paired data are often costly and impractical. To mitigate this limitation, we develop a new CMKD framework for the more challenging setting where paired data are unavailable. In particular, we establish a cross-modal distributional relationship between teacher and student models, which reveals two fundamental quantities governing effective distillation: feature alignment and label alignment. These quantities characterize semantic discrepancy between modalities at the levels of representation and prediction distributions, respectively. Motivated by this insight, we propose a principled framework, with theoretical guarantees, that enables effective cross-modal knowledge distillation by aligning distributions rather than individual samples. Extensive experiments across a wide range of multimodal benchmarks show that our framework is highly effective in both unpaired and paired data settings, improving significantly over prior work.

Cross-modal knowledge distillation can transfer diagnostic knowledge from a strong but costly teacher modality to a cheaper and more deployable student modality. In medical image analysis, however, the two modalities are often unpaired: they are collected from different patient cohorts and occupy geometrically incompatible feature spaces. This makes instance-level distillation invalid and direct feature matching unreliable. To address these challenges, we propose Shared Semantic Codebook Distillation (SSCD), which compares teacher and student representations through a shared discrete codebook. Each image is represented as a distribution over a common, modality-agnostic vocabulary, and knowledge is transferred by aligning these distributions across modalities, both globally and class-conditionally, without requiring paired samples or directly comparable raw features. The codebook is evolved online by exponential moving average and kept diverse through entropy regularization and dead-code restart. At inference, all teacher-side and codebook modules are discarded, leaving only the student encoder and classifier. On two heterogeneous unpaired settings, OCT-to-fundus retinal disease classification and CT-to-chest-X-ray pneumonia classification, SSCD improves the student from 64.5 to 70.2 macro-F1 and from 73.8 to 76.3 macro-F1, respectively, outperforming all evaluated distillation baselines on both settings. Code and pretrained models are available at https://github.com/DillanImans/SSCD-unpaired-distillation

Multimodal based approaches often outperform single modality approaches in downstream tasks as the different modalities provide complementary information, yet acquiring paired clinical data remains a significant challenge in real world scenarios. While cross-modal knowledge distillation addresses this, existing methods often struggle with large modality gaps and the propagation of noise from uncertain source-domain predictions. To overcome these challenges, we propose UnDA, an anchor-guided framework for unpaired cross-modal distillation. Our approach introduces a backbone-agnostic Alignment Module that extracts semantically structured class tokens via an attention based pooling mechanism. To ensure robust knowledge transfer, we propose Uncertainty-Weighted Optimal Transport (UCT-OT), which dynamically weights feature-level alignment based on prediction confidence, effectively suppressing noisy supervision. Furthermore, a per-class ProtoNCE objective maintains stable prototype memories to enforce global discriminability across unpaired batches. Evaluations on representative segmentation tasks under strictly unpaired settings show consistent improvements in accuracy and boundary precision in the target modality, demonstrating that meaningful structural knowledge can be transferred across heterogeneous data sources without paired datasets.