Personalized State-Transition-Aware Memory for Clinical Agents

LLM agents rely on long-term memory to retain and reuse information when performing tasks over long horizons. Existing methods provide limited support for handling memories that become outdated as new observations or domain evidence arrive. Such outdated memories may remain semantically relevant, continue to affect dependent records, and retain value as historical evidence. This calls for two capabilities: dependency tracking to identify downstream effects and historical preservation to retain useful past records. We propose Provenance-Aware Cascading Memory Invalidation (PACMI), a framework that represents memories and new evidence in a provenance graph with typed dependency edges. PACMI assigns records to a four-state validity lattice, propagates validity changes to dependent memories, and uses the resulting states for retrieval and stale-premise detection. We also introduce a diagnostic benchmark with 100 cases and 300 queries across five domains. The evaluation separates node, context-, and answer-level performance. PACMI achieves the highest final-answer accuracy on this benchmark, and its paired difference from the strongest baseline is significant under an exact McNemar test. The premise checker achieves perfect precision, recall, and F 1 on the controlled query distribution. Cascading propagation primarily improves memorystate correctness: removing it increases final-answer errors from 3 to 11, but the paired difference does not reach the 0.05 significance threshold. Code and data will be made publicly available.

Large language model (LLM) agents increasingly operate over long interaction histories, where effective reasoning requires identifying and exploiting task-relevant evidence distributed across past observations and actions. However, useful information encoded in previously computed representations is often underutilized during subsequent generation. We propose \textbf{TransMem}, a lightweight inference-time parametric memory module that transforms sparse historical hidden states from a frozen LLM backbone into reusable memory representations. TransMem uses a lightweight gating network to dynamically apply the latent intervention to the current hidden states, without repeatedly encoding the preceding context. To learn transferable memory utilization rather than task-specific knowledge, we introduce evidence-conditioned self-distillation. A memory-augmented student processes the full context and matches the predictive distribution of an evidence-only teacher that shares the same frozen backbone. Experiments on LoCoMo, HotpotQA, and MemoryAgentBench demonstrate consistent improvements across different model architectures and scales. TransMem yields gains of 11.58--29.25 $F_1$ on LoCoMo and 10.20--13.03 $F_1$ on HotpotQA, while improving the average MemoryAgentBench accuracy from 29.54% to 40.00%. These results establish sparse historical hidden states as an effective and efficient memory substrate for long-context LLM agents. Our code is available at https://github.com/Haodong-Lei-Ray/TransMem.

Long-context LLMs and Retrieval-Augmented Generation defer state tracking and evidence consolidation to query time, which is brittle when facts evolve and answers depend on latent states. We introduce Unified Memory Agent (UMA) for a one-to-many setting: query-agnostic external memory is constructed once from a stream and reused across multiple future QA sessions. A single policy maintains a structured Memory Bank through CRUD operations and answers using both the Memory Bank and raw context. Task-Stratified GRPO uses the mean reward of QA trajectories branching from each sampled memory state to supervise memory maintenance, while normalizing memory and per-question QA groups separately. We also introduce Ledger-QA, a diagnostic benchmark for long-horizon state tracking over accumulated updates. At the 16k budget, UMA-Generalist achieves the highest average score among compared methods across the test-time-learning and accurate-retrieval benchmarks and transfers to Ledger-QA without task-specific training; UMA-Specialist further improves long-horizon tracking after task adaptation. These results support learned proactive memory management for long-context reasoning.