Organizations: Brown University · Stanford University · National University of Singapore · Zhejiang University · Department of Computer Science, University of Oxford · Nanyang Technological University · Institute of Automation, Chinese Academy of Sciences
EEG foundation models (EFMs) capture reusable knowledge from large-scale EEG data, while many EEG recordings also include companion physiological signals that provide complementary information beyond the EEG-only interface. The challenge is to preserve this pretrained knowledge while extending the EFM to heterogeneous multimodal recordings through an adaptation inferred from unlabeled target data. We introduce ZeroMAG, a zero-shot multimodal adapter generation framework that extends a frozen EEG encoder and prediction head using unlabeled target recordings, without target labels or target-side optimization. The target datasets are held out from all model training and selection in the ZeroMAG pipeline. ZeroMAG organizes companion modalities around a configuration-invariant adapter, constructs a modality-subject-task condition from unlabeled recordings and task context, and generates adapter weights in a function-constrained latent space learned from source adapters. Across six held-out target datasets and three EFM backbones, ZeroMAG improves balanced accuracy by 7.22 percentage points over EEG-only inference and 4.89 points over direct weight regression, while coming within 0.50 points of supervised multimodal adaptation on average. Ablations further show that removing functional supervision from either representation learning or conditional generation degrades generated-adapter performance, confirming the contribution of both components.
Figures & tables
Figure 1: Multimodal EEG landscape and representative results. (a) Physiological information captured by common companion signals. (b) Publication trends, task-wise multimodal prevalence, and companion modality availability, based on prior surveys ( Lee et al., 2025 ; Yeung & Chu, 2022 ) . (c) Balanced accuracy on six held-out target datasets, comparing three EFM backbones with and without ZeroMAG against SleepFM and PhysioOmni.
Figure 2: Overview of ZeroMAG. The framework combines a configuration-invariant multimodal adapter, target-derived condition construction, and function-constrained conditional generation for zero-shot adapter synthesis.
Method
ISRUC-S3
HMC
MASS
SEED-V
EEGMAT
FoG
CBraMod
EEG-only
75.83±0.76
72.78±0.50
74.29±0.58
40.62±1.24
73.38±2.48
76.61±1.35
Supervised tuning
84.04±0.88
80.81±0.41
82.41±0.68
45.44±1.58
81.46±1.93
85.02±1.21
Mean source weights
74.31±0.82
72.93±0.49
75.91±0.63
39.83±1.13
73.52±0.92
76.73±0.78
Nearest source weights
76.63±0.61
73.18±0.52
76.35±0.51
40.68±1.37
74.63±0.81
77.52±0.73
Direct MLP
76.89±0.73
73.43±0.55
77.48±0.65
40.99±1.05
75.21±1.02
78.03±0.62
Table 1: Balanced accuracy (%, mean ± std over five seeds) on six held-out target datasets. Within each EEG-backbone group, ZeroMAG and the label-free baselines use the same frozen encoder and prediction head, without target labels or target-side optimization. Supervised multimodal fine-tuning is a separate reference using target training labels and all available modalities. Bold entries indicate the best target-label-free result in each group.
Component
Variant
B-ACC ↑
Δ↓
Condition
Task + modality only
62.32±0.41
11.09±0.72
Shuffled subject condition
64.17±0.53
9.24±0.98
Generator
Direct weight MLP
62.34±0.67
11.07±0.88
Modular latent MLP
65.23±0.62
8.18±0.83
Modular latent DiT (w/o MoE)
68.34±0.21
5.07±0.71
Adapter
Shared modality encoder
69.25±0.33
4.16±0.81
Table 2: Ablation results with CBraMod, averaged over all nine held-out datasets (% B-ACC, mean ± std over five seeds). Ablated results are shaded blue, and Δ denotes the decrease from Full ZeroMAG in the same run. Ablations use a separate run under the same protocol, so Full differs from the Table 1 average.
Appendix figures & tables18 assets
Supplementary material from the paper’s appendix.
Appendix
Symbol
Meaning
XEEG
EEG input to the frozen encoder.
M
Complete set of supported companion modalities.
A⊆M
Companion modalities available in a particular recording.
XA
Collection {Xm:m∈A} of available companion inputs.
R={ri}
Recording samples, with ri=(XiEEG,XiA) .
Rfit
Source samples whose labels are used to fit a reference adapter.
Appendix
Table A.1: Signal and adapter notation. Dimensions are symbolic here; numerical settings are listed in Table H.1 .
Symbol
Meaning
e(⋅;η)
Stochastic block encoder, including the cross-block transformer.
eˉ(⋅;η)
Deterministic encoder path using posterior means.
μb,ℓb
Mean and log variance of the Gaussian for block b ; ℓb is introduced here for the posterior expansion.
Ub,pre
Sampled block token before contextualization.
Eb,CBT
Block identity embedding and cross-block transformer.
U,U0,Ut
Contextualized sample, canonical latent, and noise-corrupted canonical latent.
Appendix
Table A.2: Latent, condition, and optimization notation.
Component
Reference fitting
Stage 1
Stage 2
Deployment
EEG encoder and head
Fixed
Fixed
Fixed
Fixed
Reference adapter ω∗
Updated
Fixed
Fixed
Not required
Encoder η
Not used
Updated
Fixed
Not required
Decoder ψ
Not used
Updated
Fixed
Fixed
Condition encoder ξ
Not used
Not used
Updated
Fixed
Denoiser θ
Not used
Not used
Updated
Fixed
Appendix
Table A.3: Parameter updates in the ZeroMAG pipeline. “Fixed” describes parameter values, not a zero input Jacobian.
Method
CAP
DREAMER
BCI-IV
CBraMod
EEG-only
53.86±0.83
43.91±1.04
37.82±1.31
Supervised tuning
68.16±0.64
60.20±0.98
51.11±0.89
Mean source weights
53.68±0.97
43.45±1.35
37.54±1.70
Nearest source weights
54.78±0.55
45.08±1.23
39.26±0.91
Direct MLP
55.93±0.65
46.05±0.74
41.00±1.61
Appendix
Table C.1: B-ACC (%, mean ± std over five seeds) on CAP, DREAMER, and BCI-IV. Protocol and layout as in main Table 1 .
Target
Task
Holdout
ISRUC-S3
Sleep staging
Dataset
HMC
Sleep staging
Dataset
MASS
Sleep staging
Dataset
SEED-V
Emotion recognition
Dataset
EEGMAT
Cognitive-load estimation
Dataset
FoG
Freezing-of-gait detection
Task
Appendix
Table C.2: Task coverage and holdout type of the target datasets.
Method
ISRUC-S3
HMC
MASS
CBraMod
EEG-only
75.83±0.76
72.78±0.50
74.29±0.58
Supervised reference
84.04±0.88
80.81±0.41
82.41±0.68
Mean source weights
74.31±0.82
72.93±0.49
75.91±0.63
Nearest source weights
76.63±0.61
73.18±0.52
76.35±0.51
Direct MLP
76.89±0.73
73.43±0.55
77.48±0.65
Appendix
Table C.3: Sleep staging: balanced accuracy (%, mean ± reported SD over five seeds). Bold identifies ZeroMAG in each backbone group.
Method
SEED-V
EEGMAT
FoG
CBraMod
EEG-only
40.62±1.24
73.38±2.48
76.61±1.35
Supervised reference
45.44±1.58
81.46±1.93
85.02±1.21
Mean source weights
39.83±1.13
73.52±0.92
76.73±0.78
Nearest source weights
40.68±1.37
74.63±0.81
77.52±0.73
Direct MLP
40.99±1.05
75.21±1.02
78.03±0.62
Appendix
Table C.4: Emotion, cognitive load, and gait: balanced accuracy (%, mean ± reported SD over five seeds). Bold identifies ZeroMAG in each backbone group.
Figure C.1: Gains in balanced accuracy over EEG-only and Direct MLP, in percentage points. Both panels use the same scale. Values are differences of means from main Table 1 ; no paired uncertainty or significance is inferred.
Backbone
Target
ΔEEG
ΔMLP
Gsup
Recovery (%)
CBraMod
ISRUC-S3
7.76
6.70
0.45
94.52
CBraMod
HMC
7.51
6.86
0.52
93.52
CBraMod
MASS
7.74
4.55
0.38
95.32
CBraMod
SEED-V
4.21
3.84
0.61
87.34
CBraMod
EEGMAT
7.61
5.78
0.47
94.18
CBraMod
FoG
7.86
6.44
0.55
93.46
Appendix
Table C.5: Arithmetic derived from main Table 1 ; no additional experimental runs. Recovery is 100(z−e)/(s−e) for each row.
Figure C.2: Means and reported ±1 SD for four methods within each target. Marker shapes identify backbones. Horizontal limits vary by target to show within-target differences; all values are balanced accuracy (%).
Figure D.1: Training and deployment within one separately trained backbone instantiation. Stage 1 produces the encoder and decoder. Stage 2 uses a fixed canonical latent and propagates auxiliary-loss gradients through the frozen decoder. Deployment uses unlabeled calibration data and fixed model parameters.
Figure F.1: Target-side wall-clock time measured programmatically: condition construction plus adapter generation versus supervised adaptation, under the same hardware and protocol. The 7.5 × ratio uses the reported 2- and 15-minute measurements. No timing variance or component-wise timing breakdown is inferred.
Component
Variant
B-ACC
Decrease
Condition
Task + modality only
62.32±0.41
11.09±0.72
Shuffled subject
64.17±0.53
9.24±0.98
Generator
Direct weight MLP
62.34±0.67
11.07±0.88
Modular latent MLP
65.23±0.62
8.18±0.83
Latent DiT, no MoE
68.34±0.21
5.07±0.71
Adapter
Shared encoder
69.25±0.33
4.16±0.81
Appendix
Table G.1: Component ablations from main Table 2 . B-ACC and decrease are reported in percentage points as mean ± standard deviation over five seeds. The aggregation uses CBraMod over all nine target datasets, as in main Table 2 .
Figure G.1: Performance decrease under component ablation. Markers show the decreases reported in main Table 2 relative to full ZeroMAG (B-ACC 73.41±0.71 ). Whiskers reproduce the table’s reported standard deviations of the decreases; they are not newly calculated confidence intervals. Variants are grouped by condition, generator, and adapter. These are separate interventions, not additive contributions. The aggregation covers all nine target datasets, as in main Table 2 .
Setting
B-ACC (%)
Stage 1 recon. error
Generated weight error
Prediction KL
Full
73.41±0.71
1.00
1.00
1.00
w/o Stage 1 functional
72.26±0.76
0.94
1.05
1.31
w/o Stage 2 functional
71.83±0.79
1.00
1.08
1.48
w/o both functional
70.54±0.86
0.93
1.14
1.82
Appendix
Table G.2: Functional-loss ablation. Parameter-error and KL columns are normalized to their respective Full values; lower is better. Reconstruction error evaluates the Stage 1 output against the reference adapter. Generated-weight error evaluates the final generated adapter against the same reference. KL evaluates the final generated adapter.
Group
Setting
Value
Representation
Active parameter blocks / latent shape
3M+1 / (3M+1)×128
CBT layers / hidden width / heads
2 / 256 / 8
Decoder
Experts / routing
4 / learned soft top- 2
Expert MLP widths
128→256→128
Both stages
Optimizer / learning rate / weight decay
AdamW / 10−4 / 10−4
Batch size
64 reference-adapter samples
Appendix
Table H.1: Implementation settings. M is the number of active companion modalities. Auxiliary Stage 2 losses share the same low-noise gate; diffusion loss is always active.
Figure I.1: Reported generalization and source-bank summaries from the main text. Left: recovery of supervised gain for unseen combinations and held-out modality types. Right: retention of the full-bank multimodal gain when using half the source bank. The panels have different reference denominators; no seed-level intervals are inferred.
Method family
Adapted object
Adaptation mechanism
Adapters ( Houlsby et al., 2019 )
Inserted modules
Optimize a small set of task-specific parameters.
LoRA ( Hu et al., 2022 )
Low-rank weight updates
Learn an update while freezing the original weights.
Prompt tuning ( Lester et al., 2021 )
Continuous input prompts
Optimize prompt embeddings for the task.
Tent ( Wang et al., 2021 )
Normalization parameters
Minimize prediction entropy on test inputs.
SHOT ( Liang et al., 2020 )
Target feature extractor
Adapt with a fixed source classifier and unlabeled target data.
Hypernetworks ( Ha et al., 2017 ; Karimi Mahabadi et al., 2021 )
Generated network or adapter weights
Predict parameters from a learned conditioning representation.
Appendix
Table J.1: Adaptation mechanisms in related work. Target-time optimization and conditional parameter generation are separate design choices.
Scaling EEG foundation models requires pooling data across heterogeneous electrode montages, a prerequisite both for larger pretraining corpora and for downstream deployment. We present the first systematic comparison of four channel adaptation methods (Conv1d projection, spherical spline interpolation (SSI), source-space decomposition, and Riemannian re-centering) across five pretrained EEG foundation models (5M--157M parameters), five downstream tasks, and two training regimes with 10--15 random seeds each. We find that rigid-montage models (BENDR, Neuro-GPT) require external adaptation, while flexible models (EEGPT, CBraMod) match or exceed it natively when fine-tuned but benefit from external methods under frozen-encoder deployment. A probe-SFT asymmetry exists: external adaptation can cause severe negative transfer during fine-tuning of flexible models. The optimal method is architecture-dependent (Conv1d for BENDR, SSI/Riemannian for Neuro-GPT, source-space decomposition for depression detection), and 5M-parameter CBraMod outperforms models up to 31× larger on 4/5 datasets, consistent with independent findings that compact EEG-specific architectures can match larger models.
Kuntal Kokate, Bruno Aristimunha, Dung Truong +1
Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego, La Jolla, CA 92093, USA · Yneuro, Paris, France · Centre de Recherche Cerveau et Cognition, CNRS, Université Paul Sabatier, Toulouse, France
Electroencephalography (EEG) foundation models (EFMs) have shown strong potential for transferable representation learning, yet their adaptation in realistic settings remains challenging when only a few labeled subjects are available. We show that this challenge stems from a structural mismatch between noisy, limited supervision and the highly plastic parameter space of EFMs, reflected in three key failure modes: overconfident miscalibration, prediction collapse, and representation drift caused by unconstrained parameter updates. To address these challenges, we propose SCOPE, a Structured COnfidence-aware Prototype-guided framework for label-limited EFM adaptation. SCOPE first constructs cohort-level external supervision to provide persistent guidance and further derives confidence-aware pseudo-labels to select reliable unlabeled samples for adaptation. Building on the constructed external supervision, SCOPE introduces ProAdapter, a lightweight prototype-conditioned adapter that modulates frozen EFMs to preserve pretrained representations. Experiments across 50 label-limited adaptation settings, covering 6 EEG tasks, 5 EFM backbones, and 5%-50% training labeled-subject ratios, show that SCOPE consistently achieves strong performance and efficiency.
Jingying Ma, Feng Wu, Yucheng Xing +5
Saw Swee Hock School of Public Health, National University of Singapore, Singapore · Guangzhou Research Translation and Innovation Institute, National University of Singapore, Guangzhou, China · College of Computing and Data Science, Nanyang Technological University, Singapore +3
EEG foundation models pretrained via self-supervised learning promise transferable representations, but their generalization remains limited, especially across diverse clinical datasets. Full fine-tuning is impractical for resource-constrained clinical settings due to high computational requirements. In this work, we investigate whether parameter-efficient self-supervised adaptation, updating only 9% of parameters suffices to align representations to target tasks. We evaluate our method on two state-of-the-art models with different pretraining objectives: BIOT (contrastive) and CBraMod (masked reconstruction), and evaluate on three clinical EEG datasets for abnormality detection (TUAB), event classification (TUEV), and seizure detection (CHB-MIT) under both in-distribution and out-of-distribution conditions. SSL adaptation yields consistent gains over linear probing, up to 20x AUCPR. Under a fixed compute budget, peak performance requires only 20--50% of available unlabeled data. Critically, when total window count is fixed, performance remains invariant to patient count, suggesting that performance is dependent on overall temporal window diversity only. Our findings demonstrate that parameter-efficient adaptation enables effective deployment of EEG Foundation models (EEG-FM) with minimal computational overhead and data collection burden. Code available at: https://github.com/c3n-group/efficient-eeg-adapt
Meghal Dani, Stefanie Liebe
University of Tübingen, Germany · Hertie Institute for AI in Brain Health (Hertie AI), Tübingen, Germany · Dept. of Neurology and Epileptology, University Clinic Tübingen, Germany +1