Autonomous Structuring of Radiology Reports Across Modalities at Archive Scale Using an Open-Weight Large Language Model

Imaging demand is growing faster than the radiology workforce can expand, and reporting backlogs cannot be resolved through training and recruitment alone. The most direct opportunity is reducing the time and effort radiologists spend producing reports, a task that requires interpreting images, integrating clinical history and prior studies, and drafting structured findings. We present Harrison.Rad 1.5 (HR1.5), a radiology-specific multimodal large language model that accepts interleaved text and visual inputs and generates structured and unstructured text across plain-film radiology, spanning computed radiography, chest, musculoskeletal, abdominal, spine, and pelvic x-rays, and mammography. HR1.5 is trained through a three-stage pipeline: domain adaptation of a base language model on radiology reports, contrastive vision-encoder training with curriculum-based hard negatives on ~6 million image-report instances, and visual-question-answering fine-tuning on multi-turn conversations. We evaluate it with a Findings-Diagnosis scoring framework that extends RadGraph-XL entity extraction with ontology-based synonym matching and polarity-contradiction detection, benchmarked on RadBench, a simulated FRCR 2B Short Case examination scored against Angoff-method thresholds, ReXGradient, and internal multi-modality datasets. HR1.5 is the only system evaluated to meet the simulated FRCR passing standard and achieves the highest accuracy on closed-format clinical questions, across anatomical regions, on internal multi-body-part and mammography reporting, and on the primary clinically-aligned score for public chest reporting. We further examine explainability and model behaviour, including question-sensitive Grad-CAM heatmaps, attention analysis, and confidence estimation, to support responsible future evaluation toward clinical use, and a framework for clinically grounded assessment of report quality.

Structured radiology reporting mitigates the heterogeneity of free-text reports, yet its benefits depend on high-quality reporting templates. In practice, such templates are conventionally built through labor-intensive expert consensus and therefore vary across institutions and lag behind evolving clinical practice. Large language models (LLMs) enable automated template induction, but existing approaches remain limited: single-LLM induction is constrained by context length, and the corpus-scale method ASTAR produces a static, closed-corpus template without external grounding or downstream adaptation. To address these limitations, we propose TEMPLAR, a TEMPLate-centric Agentic framework for inducing and evolving standardized Radiology reporting templates from large-scale clinical corpora. TEMPLAR treats the template as a persistent central state maintained alongside two provenance-aware knowledge graphs, namely an anatomical graph that constrains template construction and a diagnostic graph that supports finding-to-diagnosis reasoning. Three agents operate on this state. The Induction Agent derives canonical clinical slots from anatomy-constrained Span-Triple atoms via dual-view similarity clustering; the Evolution Agent then assembles these slots into a hierarchical template and revises it under consistency constraints, external clinical evidence, and downstream structuring feedback; and the Clinical Agent applies the evolved template to report structuring, reconstruction, and diagnostic reasoning. Across four datasets, TEMPLAR outperforms ASTAR, three medical LLMs, and six general-purpose LLMs in coverage, information fidelity, and diagnostic fidelity, while achieving the highest or tied-highest LLM-rated template quality. Its fidelity advantages over ASTAR persist under cross-dataset transfer, and cumulative ablations support complementary contributions of its key components.

Radiology reports remain the primary mechanism by which imaging findings are communicated to clinical teams. However, much of the structured information behind these reports, including measurements, image evidence, prior comparisons, lesion identity, uncertainty, and terminology, often remains trapped in free text or fragmented across picture archiving and communication systems, radiology information systems, reporting workstations, worksheets, advanced visualization tools, and electronic health records. This paper proposes a human-supervised, evidence-linked reference architecture for structured radiology reporting. The framework combines exam-specific templates, speech-to-structure processing, measurement and segmentation capture, controlled AI-assisted drafting, and standards-based interoperability using DICOM, DICOM Structured Reporting, DICOM Segmentation, HL7 FHIR, RadLex, SNOMED CT, LOINC, and UCUM. The system is positioned not as an autonomous report generator, but as a structured intelligence layer for enterprise imaging that supports reviewed reporting, longitudinal comparison, clinical data reuse, governance, and integration with PACS, RIS, EHR, analytics, and registry workflows. The paper also discusses modality-specific deployment considerations, clinical safety risks, validation requirements, cybersecurity, privacy, quality management, and regulatory boundaries for AI-assisted radiology reporting systems.