SciFusion: Physics-Guided Compositional Diffusion for Multimodal 3D Scientific Image Generation

Generative deep learning methods such as Variational Autoencoders, Generative Adversarial Networks or Diffusion Models have achieved remarkable results in image synthesis. In particular, Diffusion Models have demonstrated superior image fidelity and sample diversity compared to other approaches on standard benchmarks, while also offering more flexible training dynamics as evidenced both in natural image domains and in medical applications. In medical imaging including Computed Tomography, Magnetic Resonance Imaging or Positron Emission Tomography, such models have various important use-cases including data augmentation, domain transfer, image reconstruction, inpainting, image augmentation and artifact correction. Further, generated images can be conditioned on patient characteristics, medical reports, segmentation masks or other images. Specific challenges arise due to the 3D volumetric nature of medical images, which translate to substantial demands in terms of memory, compute, and training data. This article provides a comparative overview of 3D Diffusion Models which have been developed for medical images, with a focus on current performance, limitations, and an outlook for future work.

Synthetic data generation has emerged as a powerful tool for improving data scalability in computer vision. Recent diffusion-based pipelines have demonstrated strong photorealism. However, how to enforce precise 3D structure and pose consistency in generated images remains challenging. Existing methods leverage visual prompts such as edge maps to guide diffusion models, but often suffer from over-conditioning artifacts that degrade image realism and limit dataset quality. In this paper, we present a diffusion-based image generation framework that enforces 3D structural alignment while preserving photorealism through adaptive conditioning. Our framework, Adaptive Conditioning for 3D-Aware Synthetic Data Generation (AC3S), introduces a self-supervised visual prompt modulator that dynamically adjusts the strength of ControlNet conditioning, preventing over-conditioning and enabling the diffusion model to retain its generative expressiveness. To further enhance diversity and semantic consistency, we develop a multi-agent vision language model framework that composes detailed and 3D-aware prompts aligned with the underlying geometric structure. Together, these components enable the scalable generation of high-quality synthetic datasets with accurate 2D and 3D annotations. Extensive experiments demonstrate that our method significantly improves image quality and downstream utility.

Conditional medical image generation plays an important role in many clinically relevant imaging tasks. However, existing methods still face a fundamental challenge in balancing inference efficiency, patient-specific fidelity, and distribution-level plausibility, particularly in high-dimensional 3D medical imaging. In this work, we propose GDM, a generative drifting framework that reformulates deterministic medical image prediction as a multi-objective learning problem to jointly promote distribution-level plausibility and patient-specific fidelity while retaining one-step inference. GDM extends drifting to 3D medical imaging through an attractive-repulsive drift that minimizes the discrepancy between the generator pushforward and the target distribution. To enable stable drifting-based learning in 3D volumetric data, GDM constructs a multi-level feature bank from a medical foundation encoder to support reliable affinity estimation and drifting field computation across complementary global, local, and spatial representations. In addition, a gradient coordination strategy in the shared output space improves optimization balance under competing distribution-level and fidelity-oriented objectives. We evaluate the proposed framework on two representative tasks, MRI-to-CT synthesis and sparse-view CT reconstruction. Experimental results show that GDM consistently outperforms a wide range of baselines, including GAN-based, flow-matching-based, and SDE-based generative models, as well as supervised regression methods, while improving the balance among anatomical fidelity, quantitative reliability, perceptual realism, and inference efficiency. These findings suggest that GDM provides a practical and effective framework for conditional 3D medical image generation.