Fed-Universe: A Semantic-Geometric-Topological-Human (S-G-T-H) Stack for Negotiated Alignment in Federated Systems

The deployment of Federated Learning (FL) in multi-center clinical networks faces the challenge of "knowledge dominance," where high-volume hubs naturally overwhelm minority community nodes, implicitly treating the distinct clinical patterns of smaller cohorts as outliers. Existing geometric defenses provide a security baseline but leave this efficiency-fairness dilemma unresolved. To bridge this gap, we propose Fed-Equilibrium, a framework that advances the paradigm from simple defense to topological equilibrium. Unlike traditional aggregators, Fed-Equilibrium implements a sequential architectural synergy. It utilizes a two-stage gradient control cascade: Stage I (geometric quality assurance) enforces directional consistency via a cosine similarity funnel to filter malicious noise, creating a stabilized manifold; Stage II (topological Pareto control) then actively modulates verified contributions by identifying the optimal Pareto knee point. We validated this framework on a bi-national simulation integrating Canadian (CNODES) and U.S. (SyntheticMass) registries. Experimental results demonstrate that the system simultaneously secures the network against adversarial divergence while accommodating underrepresented signals. Notably, the minority U.S. spoke (representing less than 3% of data volume) achieved deep convergence comparable to the data-rich Canadian hub. This confirms that Fed-Equilibrium effectively counters "knowledge dominance," establishing a true "knowledge commons" where global generalizability does not come at the cost of local clinical representation.

Federated learning (FL) enables collaborative model training across distributed clients while keeping data local. A central challenge is determining which client updates are beneficial for aggregation with respect to each client's target domain. Existing methods typically address this problem in parameter space by comparing model parameters or gradients. However, parameter-space similarity can be a poor proxy for predictive behavior, especially under heterogeneous, non-IID data. Consequently, updates that are misaligned with a client's target domain, including those caused by heterogeneous data or malfunctioning clients, may degrade local model performance. We propose Local Inference Guided Aggregation for Heterogeneous Training Environments to Yield Enhancement Through Agreement and Regularization (LIGHTYEAR), a federated learning framework that performs update selection in function space. LIGHTYEAR uses an NTK-based agreement score to characterize predictive behavior and determine a personalized aggregation set for each client. By relating model parameters to local predictive responses, the Neural Tangent Kernel (NTK) provides a more expressive criterion for update selection than parameter-space similarity alone. Because function-space information is not available before aggregation in conventional centralized FL, LIGHTYEAR uses a peer-to-peer (P2P) topology in which clients exchange updates directly and evaluate incoming models on private validation data. Each client selects only updates that are beneficial for its own target domain and aggregates them using a regularized rule that improves stability under heterogeneity. Across five datasets and nine baseline methods, LIGHTYEAR consistently outperforms centralized FL baselines and existing P2P approaches.

Federated learning (FL) enables collaborative learning over decentralized data silos without centralizing raw data. However, heterogeneous local architectures often induce non-aligned representation spaces, making it difficult to transfer global knowledge across silos. Existing paradigms share this knowledge as model parameters, distilled predictions, or class prototypes, yet all encode it in an absolute space that must be aligned across clients. Heterogeneous backbones break this alignment, so the shared knowledge becomes unreliable and misleads local training. We propose FedTopo, a relation-level framework that encodes global knowledge as class relation topology, capturing how classes relate within each client rather than where they lie in feature space. Each client builds its relation topology from local prototypes and uploads it with class statistics. The server then aggregates these relations in a reliability-aware manner that down-weights weakly supported ones, and broadcasts the global topology to clients. The global topology guides local training by emphasizing topology-similar negative classes. Experiments on three datasets under eight heterogeneous backbones show that FedTopo consistently outperforms parameter-, distillation-, and prototype-sharing baselines, with low communication and no inference overhead. Our code is available at https://github.com/Zhaoyang-Ma/FedTopo.