Organizations: School of Mathematical Sciences, Capital Normal University, Beijing 100048, China · National Center for Applied Mathematics Beijing, Capital Normal University, and the Academy for Multidisciplinary Studies, Capital Normal University, Beijing 100048, China
Although low-dose, sparse-view, and limited-angle CT involve distinct degradation mechanisms, all three pose reconstruction challenges due to limited measurement information and can therefore be addressed within a unified framework. In iterative image restoration with flow matching, prediction errors may cause inference states to deviate from the prescribed training path, while a fixed initialization may be unsuitable for inputs with varying degradation severity. We propose a unified conditional flow matching method that conditions on the initial reconstruction and combines feedback-aware training with degradation-adaptive initialization. During training, a teacher network simulates inference updates to generate shifted states, from which a student network learns to recover high-quality reference images, improving its ability to handle prediction errors. During inference, the starting time is selected based on the noise level or extent of missing projection data, and the noise added to the initial state is adjusted accordingly to adapt the starting point to the input. Experiments on public benchmark datasets show that the proposed method achieves better quantitative results than the compared methods across all three reconstruction tasks, effectively suppressing noise and artifacts while preserving anatomical structures and details.
Figures & tables
Fig. 1: Motivation and key mechanisms of FFAI. (A) The three CT tasks share a unified training procedure, with parameters learned separately for each task. (B) Feedback-based error correction: shifted states generated by teacher-simulated inference are incorporated into training, with high-quality reference images supervising restoration to improve the network’s ability to handle prediction errors. (C) Degradation adaptation: the starting time and initial state are jointly determined by the input degradation severity to accommodate different restoration needs.
Fig. 2: Unified training framework for the three tasks. Each task uses the initial reconstruction as a condition and shares the same flow matching and feedback training mechanisms, while network parameters are learned independently. After training, the student model for each task is retained for inference.
Fig. 3: Feedback-aware FM training. The standard branch learns the target velocity at the prescribed path state xtR . In the feedback branch, the EMA teacher performs a single update from xtL to generate a stop-gradient feedback state xtR , and the student’s endpoint prediction is supervised by the reference image. tL and tR are the nearest inference nodes on either side of the randomly sampled time t .
Fig. 4: Degradation-adaptive inference. The starting time τω is selected from the degradation descriptor qω , and the corresponding initial state is constructed. Conditioned on the fixed image cω , the task-specific student network performs Euler updates along a decreasing time grid to obtain the final reconstruction.
Metric
FBP
Noise2Noise
MTD-GAN
FoundDiff
TAMP
FORCE
FFAI
PSNR (dB) ↑
40.99 ± 0.08
41.79 ± 0.23
46.03 ± 0.08
45.51 ± 0.06
42.45 ± 1.13
40.81 ± 0.33
48.30 ± 0.05
SSIM (%) ↑
93.70 ± 0.14
95.50 ± 0.10
97.81 ± 0.05
97.87 ± 0.53
96.43 ± 1.39
96.04 ± 0.47
97.96 ± 0.39
TABLE I: Quantitative results for quarter-dose CT reconstruction (mean ± standard deviation). SSIM is reported as a percentage. Bold and underlined values indicate the best and second-best means, respectively.
Fig. 5: Quarter-dose CT reconstructions obtained with different methods. Representative pelvic, thoracic, and abdominal slices are shown from top to bottom. In each group, the upper row shows CT images, and the lower row shows difference maps relative to the full-dose reference. Reference denotes the full-dose reference image, LDCT denotes the quarter-dose input image, and Proposed denotes FFAI. The display window is [−260,340] HU, and the color scale for the difference maps spans [−100,100] .
Method
60∘
90∘
PSNR (dB) ↑
SSIM (%) ↑
PSNR (dB) ↑
SSIM (%) ↑
FBP
17.28 ± 1.97
53.55 ± 3.06
19.62 ± 1.89
64.09 ± 4.05
IRON
31.57 ± 1.70
90.36 ± 3.26
35.61 ± 3.65
94.60 ± 2.66
ProCT
34.98 ± 1.59
92.56 ± 2.00
38.83 ± 1.90
95.67 ± 1.52
TLIR
20.33 ± 1.14
54.57 ± 12.04
25.23 ± 3.02
46.09 ± 3.59
TAMP
20.79 ± 1.75
60.87 ± 3.33
24.57 ± 3.01
77.62 ± 2.53
TABLE II: Quantitative results for 60∘ and 90∘ limited-angle CT reconstruction (mean ± standard deviation). SSIM is reported as a percentage. Bold and underlined values indicate the best and second-best means, respectively, for each angular range.
Fig. 6: Reconstructions obtained with different methods under the 60∘ limited-angle setting. The upper and lower groups show representative thoracic and abdominal slices, respectively. In each group, the upper row shows CT images, and the lower row shows difference maps relative to the reference. Reference denotes the full-dose reference image, and Proposed denotes FFAI. The display window is [−260,340] HU, and the color scale for the difference maps spans [−200,200] .
Fig. 7: Reconstructions obtained with different methods under the 90∘ limited-angle setting. The upper and lower groups show representative thoracic and abdominal slices, respectively. In each group, the upper row shows CT images, and the lower row shows difference maps relative to the reference. Reference denotes the full-dose reference image, and Proposed denotes FFAI. The display window is [−260,340] HU, and the color scale for the difference maps spans [−200,200] .
Method
40 views
80 views
PSNR (dB) ↑
SSIM (%) ↑
PSNR (dB) ↑
SSIM (%) ↑
FBP
26.65 ± 1.07
48.52 ± 2.82
32.25 ± 0.79
73.07 ± 1.62
LipCT
37.29 ± 0.56
87.27 ± 0.97
39.25 ± 0.21
90.72 ± 0.86
MetaInv
35.56 ± 1.76
84.50 ± 2.34
37.08 ± 1.14
88.08 ± 0.97
DPS
32.33 ± 0.40
74.75 ± 1.14
32.42 ± 0.43
75.04 ± 0.96
TAMP
30.25 ± 0.65
80.55 ± 1.07
36.00 ± 0.49
89.11 ± 0.95
TABLE III: Quantitative results for sparse-view CT reconstruction with 40 and 80 views (mean ± standard deviation). SSIM is reported as a percentage. Bold and underlined values indicate the best and second-best means, respectively, for each view setting.
Fig. 8: CT reconstructions obtained with different methods under the 40 -view sparse-sampling setting. The upper and lower groups show representative thoracic and abdominal slices, respectively. In each group, the upper row shows CT images, and the lower row shows difference maps relative to the reference. Reference denotes the full-dose reference image, and Proposed denotes FFAI. The display window is [−260,340] HU, and the color scale for the difference maps spans [−200,200] .
Fig. 9: CT reconstructions obtained with different methods under the 80 -view sparse-sampling setting. The upper and lower groups show representative thoracic and abdominal slices, respectively. In each group, the upper row shows CT images, and the lower row shows difference maps relative to the reference. Reference denotes the full-dose reference image, and Proposed denotes FFAI. The display window is [−260,340] HU, and the color scale for the difference maps spans [−200,200] .
Fig. 10: CT reconstructions obtained with different ablation variants. From top to bottom, the three groups correspond to quarter-dose, 60∘ limited-angle, and 40 -view sparse-view experiments. In each group, the upper row shows the reconstructions and the lower row shows their differences from the reference images. W/o FAT and W/o AS denote the variants without feedback-aware training and with a fixed starting point, respectively. Proposed denotes the full FFAI model. The color scale for the difference maps is [−200,200] .
Variant
FAT
AS
LDCT (25%)
LACT ( 60∘ )
SVCT (40 views)
PSNR (dB) ↑
SSIM (%) ↑
PSNR (dB) ↑
SSIM (%) ↑
PSNR (dB) ↑
SSIM (%) ↑
W/o FAT
×
✓
41.44 ± 1.60
93.91 ± 2.17
28.97 ± 1.80
74.35 ± 2.98
34.87 ± 0.68
79.88 ± 1.20
W/o AS
✓
×
30.71 ± 1.77
81.85 ± 2.20
32.69 ± 0.94
82.44 ± 1.39
35.42 ± 0.63
81.12 ± 1.01
FFAI
✓
✓
48.30 ± 0.05
97.96 ± 0.39
38.94 ± 1.79
94.28 ± 2.07
39.08 ± 0.31
90.55 ± 1.18
TABLE IV: Ablation results for quarter-dose, 60∘ limited-angle, and 40 -view sparse-view CT reconstruction (mean ± standard deviation). FAT and AS denote feedback-aware training and an adaptive starting point, respectively. ✓ and × indicate whether each component is enabled or removed; removing AS corresponds to using a fixed starting point. SSIM is reported as a percentage, and boldface indicates the best mean values.
Fig. 11: Quantitative comparison of cross-dataset generalizability. Low-dose CT (LDCT) uses 25% of routine dose, sparse-view CT (SVCT) uses 80 projection views, and limited-angle CT (LACT) uses a 90∘ angular range. Circles and squares indicate PSNR (dB) and SSIM ( % ), respectively. Proposed denotes the proposed method.
Computed tomography uses X-ray measurements from multiple angles to reconstruct cross-sectional and volumetric images for diagnosis and scientific imaging.
School of Mathematical Sciences, Capital Normal University, Beijing 100048, China · National Center for Applied Mathematics Beijing, Capital Normal University and Academy for multidisciplinary studies, Capital Normal University, Beijing, 100048, China