Training-Free Motion-Corrected 3D Brain MRI Reconstruction via Event-Guided References

Magnetic resonance imaging (MRI) is highly susceptible to patient motion due to its relatively long acquisition times and the fact that data are acquired sequentially in k-space. Even small patient movements introduce phase inconsistencies across measurements, leading to severe artifacts such as blurring, ghosting, and geometric distortions that can compromise diagnostic quality. Retrospective motion compensation remains challenging, particularly in accelerated acquisitions, due to the ill-posed nature of the joint reconstruction and motion estimation problem. In this work, we propose a unified Bayesian framework for motion-compensated 3D MRI that jointly estimates the anatomical image, rigid-body motion parameters, and coil sensitivity maps directly from motion-corrupted k-space data. Our approach integrates pretrained 3D complex-valued score-based diffusion models as expressive anatomical image priors within a physics-based forward model. Inference is performed by alternating diffusion posterior image updates with efficient proximal optimization steps for motion and coil sensitivity estimation, enabling fully unsupervised reconstruction without the need for paired motion-free training data. Experiments on simulated and real-motion brain MRI datasets demonstrate that the proposed method achieves improved image quality and motion robustness compared to state-of-the-art classical and learning-based motion correction techniques, particularly in the presence of severe motion and high acceleration.

Patient motion remains a source of image degradation in brain MRI, leading to signal loss, blurring, and geometric distortion that compromise quantitative analysis. Existing deep learning methods for motion correction typically rely on paired clean-corrupted data or k-space acquisitions, which are rarely available in clinical settings. We propose SSRL-MAR, a motion artifact-aware unpaired representation learning framework for motion artifact reduction that requires neither paired training data nor explicit motion labels. SSRL-MAR employed a three-stage training strategy: (1) contrastive learning on 3D patches to extract motion representations by contrasting clean and synthetically corrupted images, (2) a motion artifact-aware synthesis network to generate motion artifacts from clean scans, and (3) a motion artifact-aware generator to restore clean volumes using the learned degrader for self-supervised supervision. On in-silico dataset, SSRL-MAR achieved PSNR 23.81dB, SSIM 91.55%, and NMSE 0.79%. On in-vivo MR-ART dataset, the pretrained model reduced motion distortion, and unsupervised domain adaptation further improved anatomical fidelity. Against a source-only supervised model trained on the same simulated pairs, SSRL-MAR improved PSNR by up to 2.0 dB on MR-ART after unsupervised domain adaptation, and remained within 0.25-0.47 dB of an oracle supervised model that requires real paired data unavailable in practice. At the milder motion level, volumetric error in structures such as the corpus callosum and ventricular system decreased by more than 50%, confirming improved neuroanatomical consistency. These results indicate that SSRL-MAR provides a robust and scalable image-domain solution for 3D brain MRI motion correction, enabling reliable structural quantification in large-scale neuroimaging studies without requiring prospectively acquired pairs or acquisition-specific calibration.

Object: Motion artefacts remain a major limitation of routine two-dimensional T2-weighted turbo spin-echo (TSE) brain MRI, reducing diagnostic confidence and often necessitating repeated acquisitions. MoSAIK (Motion Search with AI in K-space) retrospectively estimates in-plane rigid-body motion directly from standard multi-coil TSE k-space. Without a motion-free reference, external navigators, or additional acquisitions, MoSAIK infers motion from k-space self-consistency violations and incorporates predicted parameters into model-based, motion-aware reconstruction rather than synthesizing corrected images. Materials and Methods: Selected complex coil data were represented as log-magnitude and phase channels. A decoupled convolutional embedding and Transformer encoder estimated phase-encoding-line-indexed rotation and two-dimensional translations. Training used motion-free clinical acquisitions with simulated motion; four held-out subjects were evaluated. Component-wise errors assessed estimation; SSIM and PSNR in silico and entropy focus criterion (EFC) in vivo assessed reconstruction. Results: Motion estimation errors were low for both rotation (MSE $<$ 0.2 deg$^2$) and translation (MSE $<$ 0.2 pixels$^2$), with Pearson correlations of approximately 0.96 and 0.94, respectively. In every in-vivo acquisition, more than 75% of slices showed information gain relative to uncorrected reconstructions. MoSAIK reduced visible artefacts while preserving anatomical detail. Discussion: Transformer-based k-space motion-trajectory estimation enables fast retrospective correction of standard clinical TSE brain MRI.