cs.AINov 1, 2026

Does reflective LLM feedback survive a wet-lab-scale label budget?

Authors: Haoxuan Zeng, Xin Luo

Organizations: University of Michigan, Ann Arbor, Michigan, USA

Abstract

Can reflective language-model feedback improve a biological predictor when each cycle buys only one plate of labels? We separate three possible sources of benefit: proposing model edits, choosing measurements, and revising decisions through repeated feedback. We replay 3636 ProteinGym assays, starting with 9696 labels and acquiring 9696 per round for six rounds, with a sealed test set and a shared edit schema. The pre-specified comparison of full LLM control against random edits detects no advantage in test rank correlation (Δz=−0.008Δz=-0.008, 95%95\% CI [−0.034,+0.018][-0.034,+0.018]); equivalence is also unestablished. Exploratory ablations nevertheless identify useful model editing. With random acquisition fixed, LLM edits improve Fisher-transformed test Spearman by 0.0430.043 over no edits; with acquisition fixed to upper confidence bound, they improve normalized top-variant recovery by 0.0230.023. LLM acquisition alone does not detectably outperform fixed adaptive rules, and repeated feedback does not detectably outperform one initial recommendation under full control. Thus, the observed gains support constrained specialist editing, while the incremental value of recursive reflection remains unestablished at this label budget.

Figures & tables

Appendix figures & tables6 assets

Supplementary material from the paper’s appendix.

Appendix

Explore similar work

Jul 31, 2026

Reflection or Re-Generation? Why LLM Revision Fails Where Human Revision Succeeds

Reflection, the ability to revisit and revise prior reasoning, is central to how humans improve their answers. Large language models (LLMs) are increasingly prompted to "reflect," yet whether this resembles human revision remains unclear. We introduce the Human-LLM Reflection Framework (HRF), a controlled two-pass protocol comparing human and LLM revision under identical conditions across self-, peer-, and cross-agent settings. Using an information-theoretic analysis based on per-iteration cross-entropy reduction, we find two failure modes of LLM reflection. On objective tasks with finite answer spaces, reflection yields near-zero information gain (Delta I approx 0), behaving as neutral re-generation indistinguishable from re-sampling. On subjective tasks, it yields significant negative gain (Delta I < 0), moving predictions away from the target. Human revision, by contrast, yields positive gain in both settings. Cross-agent experiments localize the failure to the revision step, not input quality: LLMs degrade even high-quality human responses. Diagnostic analyses (revision conditioned on first-pass correctness, and oracle-guided revision against a random-reshuffle baseline) show that which sub-step dominates varies by task and by model rather than reducing to a single mechanism: self-error detection is present on objective multiple-choice tasks but weak on subjective ones, and recovery under an oracle error signal exceeds the baseline for some models and falls below it for others. The unifying account is structural: without external information, self-conditioned revision cannot reduce uncertainty about the target, so LLM reflection is better understood as conditioned re-generation than as genuine error-driven revision.
Oct 16, 2026

Language Models Learn to Improve Language Models

Large language models (LLMs) are increasingly used to automate AI research, including language-model (LM) development, offering a potential path toward recursive self-improvement. However, turning experimental feedback into a learned ability to propose effective improvements across models faces two challenges. First, training such an ability with real feedback is expensive: reinforcement learning (RL) requires evaluating tens of thousands of proposals, each potentially requiring a full model-training run. Even at ten GPU-hours per run, reward collection alone would consume hundreds of thousands of GPU-hours, motivating a cheaper surrogate. Second, surrogate feedback can become unreliable as policy optimization favors overestimated proposals when the proposal distribution shifts. To address these challenges, we propose LM2LM, which trains LLMs with RL to generate effective LM improvement proposals. To provide scalable feedback, we use a research world model (RWM), a frozen LLM that predicts proposal gains from real experimental records provided in context, as the reward model for RL. To maintain feedback reliability, we periodically execute current-policy proposals ranked highly by the RWM and add their measured outcomes to its context. Across eight autoregressive and diffusion LM development environments, real-execution evaluations on held-out tasks show that LM2LM enables Qwen3.8-27B to outperform GPT-6-sol, even when GPT-6-sol is given 300 real experimental records in context, while requiring 33% lower data-generation cost. LM2LM also generalizes to a model family unseen during training.
Oct 1, 2025

In-Place Feedback: Reliable Refinement for Multi-Turn Expert-LLM Collaboration

LLM-generated drafts often contain subtle factual or logical errors, yet prior work shows that models struggle to reliably integrate multi-turn feedback aimed at fixing them. We propose in-place feedback, an interaction paradigm in which the user directly edits the model's previous response and the model continues generation from the edited context. In-place feedback consistently outperforms standard multi-turn feedback across five reasoning-intensive benchmarks while requiring fewer tokens, and our fine-grained analysis shows that it applies corrections more reliably and propagates them to subsequent reasoning. A user study with domain experts refining LLM-generated summaries corroborates these findings: participants report higher final-output satisfaction and substantially lower fatigue with in-place feedback, and a mixed strategy combining in-place and multi-turn feedback improves every dimension we measure. These results suggest that editing errors in place is a more reliable way to incorporate expert corrections than multi-turn feedback, while combining the two acts complementarily to form a more effective collaboration than either mechanism alone.