Feb 24, 2026J/K move · Enter open · S save
Ziwei Niu, Hao Sun, Shujun Bian, Xihong Yang+3
Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore · College of Computer Science and Technology, Zhejiang University, Hangzhou, China · College of information science and engineering, Ritsumeikan university, ibaraki Osaka, Japan+1
Accurate interpretation of electrocardiogram (ECG) signals is crucial for diagnosing cardiovascular diseases. Recent multimodal approaches that integrate ECGs with accompanying clinical reports show strong potential, but they still face two main concerns from a modality perspective: (1) intra-modality: existing models process ECGs in a lead-agnostic manner, overlooking spatial-temporal dependencies across leads, which restricts their effectiveness in modeling fine-grained diagnostic patterns; (2) inter-modality: existing methods directly align ECG signals with clinical reports, introducing modality-specific biases due to the free-text nature of the reports. In light of these two issues, we propose CG-DMER, a contrastive-generative framework for disentangled multimodal ECG representation learning, powered by two key designs: (1) Spatial-temporal masked modeling is designed to better capture fine-grained temporal dynamics and inter-lead spatial dependencies by applying masking across both spatial and temporal dimensions and reconstructing the missing information. (2) A representation disentanglement and alignment strategy is designed to mitigate unnecessary noise and modality-specific biases by introducing modality-specific and modality-shared encoders, ensuring a clearer separation between modality-invariant and modality-specific representations. Experiments on three public datasets demonstrate that CG-DMER achieves state-of-the-art performance across diverse downstream tasks.