Graph Contrastive Learning

Sequential recommendation has become increasingly prominent in both academia and industry, particularly in e-commerce. The primary goal is to extract user preferences from historical interaction sequences and predict items a user is likely to engage with next. Recent advances have leveraged contrastive learning and graph neural networks to learn more expressive representations from interaction histories -- graphs capture relational structure between nodes, while ID-based representations encode item-specific information. However, few studies have explored multi-view contrastive learning between ID and graph perspectives to jointly improve user and item representations, especially in settings where only interaction data is available without auxiliary information. To address this gap, we propose Multi-View Contrastive learning for sequential recommendation (MVCrec), a framework that integrates complementary signals from both sequential (ID-based) and graph-based views. MVCrec incorporates three contrastive objectives: within the sequential view, within the graph view, and across views. To effectively fuse the learned representations, we introduce a multi-view attention fusion module that combines global and local attention mechanisms to estimate the likelihood of a target user purchasing a target item. Comprehensive experiments on five real-world benchmark datasets demonstrate that MVCrec consistently outperforms 11 state-of-the-art baselines, achieving improvements of up to 14.44% in NDCG@10 and 9.22% in HitRatio@10 over the strongest baseline. Our code and datasets are available at https://github.com/sword-Lz/MMCrec.

Spectral graph contrastive learning often constructs low- and high-frequency views to capture complementary graph signals, but these views are commonly combined by graph-level or node-agnostic fusion rules. We show that graph-level fusion can incur irreducible regret on mixed graphs with separated node-wise spectral preferences. Motivated by this result, we propose ASPECT, a spectral graph contrastive learning method that adaptively fuses low- and high-frequency views at the node level. ASPECT learns a node-wise spectral policy and regularizes it using channel-wise contrastive evidence, enabling different nodes to use different spectral mixtures. We further introduce ASPECT-S, an optional stability-aware extension that uses generated graph-structure and feature perturbations to obtain empirical channel-wise sensitivity estimates, together with a Rayleigh-based spectral search bias for producing informative perturbations. Experiments on homophilic and heterophilic benchmarks show that ASPECT improves representation quality over competitive spectral and graph contrastive baselines, while ASPECT-S further improves performance under joint graph-structure and feature perturbations.

While spatial transcriptomics (ST) has advanced our understanding of gene expression in tissue context, its high experimental cost limits its large-scale application. Predicting ST from pathology images is a promising, cost-effective alternative, but existing methods struggle to capture complex cross-slide spatial relationships. To address the challenge, we propose SpaHGC, a multi-modal heterogeneous graph-based model that captures both intra-slice and inter-slice spot-spot relationships from histology images. It integrates local spatial context within the target slide and cross-slide similarities computed from image embeddings extracted by a pathology foundation model. These embeddings enable inter-slice knowledge transfer, and SpaHGC further incorporates Masked Graph Contrastive Learning to enhance feature representation and transfer spatial gene expression knowledge from reference to target slides, enabling it to model complex spatial dependencies and significantly improve prediction accuracy. We conducted comprehensive benchmarking on seven matched histology-ST datasets from different platforms, tissues, and cancer subtypes. The results demonstrate that SpaHGC significantly outperforms the existing nine state-of-the-art methods across all evaluation metrics. Additionally, the predictions are significantly enriched in multiple cancer-related pathways, thereby highlighting its strong biological relevance and application potential.

Collaborative filtering (CF) recommendation has been significantly advanced by integrating Graph Neural Networks (GNNs) and Graph Contrastive Learning (GCL). However, (i) random edge perturbations often distort critical structural signals and degrade semantic consistency across augmented views, and (ii) data sparsity hampers the propagation of collaborative signals, limiting generalization. To tackle these challenges, we propose RaDAR (Relation-aware Diffusion-Asymmetric Graph Contrastive Learning Framework for Recommendation Systems), a novel framework that combines two complementary view generation mechanisms: a graph generative model to capture global structure and a relation-aware denoising model to refine noisy edges. RaDAR introduces three key innovations: (1) asymmetric contrastive learning with global negative sampling to maintain semantic alignment while suppressing noise; (2) diffusion-guided augmentation, which employs progressive noise injection and denoising for enhanced robustness; and (3) relation-aware edge refinement, dynamically adjusting edge weights based on latent node semantics. Extensive experiments on three public benchmarks demonstrate that RaDAR consistently outperforms state-of-the-art methods, particularly under noisy and sparse conditions.

Mental disorder populations exhibit pronounced heterogeneity -- that is, the significant differences between samples -- poses a significant challenge to the definition of positive pairs in contrastive learning. To address this, we propose a subtype-guided contrastive learning framework that models patient heterogeneity as latent subtypes and incorporates them as structural priors to guide discriminative representation learning. Specifically, we construct multi-view representations by combining patients' clinical text with graph structure adaptively learned from BOLD signals, to uncover latent subtypes via unsupervised spectral clustering. A dual-level attention mechanism is proposed to construct prototypes for capturing stable subtype-specific connectivity patterns. We further propose a subtype-guided contrastive learning strategy that pulls samples toward their subtype prototype graph, reinforcing intra-subtype consistency for providing effective supervisory signals to improve model performance. We evaluate our method on Major Depressive Disorder (MDD), Bipolar Disorder (BD), and Autism Spectrum Disorders (ASD). Experimental results confirm the effectiveness of subtype prototype graphs in guiding contrastive learning and demonstrate that the proposed approach outperforms state-of-the-art approaches. Our code is available at https://anonymous.4open.science/r/BrainSCL-06D7.

Dynamic functional connectivity captures time-varying brain states for better neuropsychiatric diagnosis and spatio-temporal interpretability, i.e., identifying when discriminative disease signatures emerge and where they reside in the connectivity topology. Reliable interpretability faces major challenges: diagnostic signals are often subtle and sparsely distributed across both time and topology, while nuisance fluctuations and non-diagnostic connectivities are pervasive. To address these issues, we propose BrainSTR, a spatio-temporal contrastive learning framework for interpretable dynamic brain network modeling. BrainSTR learns state-consistent phase boundaries via a data-driven Adaptive Phase Partition module, identifies diagnostically critical phases with attention, and extracts disease-related connectivity within each phase using an Incremental Graph Structure Generator regularized by binarization, temporal smoothness, and sparsity. Then, we introduce a spatio-temporal supervised contrastive learning approach that leverages diagnosis-relevant spatio-temporal patterns to refine the similarity metric between samples and capture more discriminative spatio-temporal features, thereby constructing a well-structured semantic space for coherent and interpretable representations. Experiments on ASD, BD, and MDD validate the effectiveness of BrainSTR, and the discovered critical phases and subnetworks provide interpretable evidence consistent with prior neuroimaging findings. Our code: https://anonymous.4open.science/r/BrainSTR1.

Multivariate time-series anomaly detection is essential for reliable industrial control, telemetry, and service monitoring. However, the evolving inter-variable dependencies and inevitable noise render it challenging. Existing methods often use single-scale graphs or instance-level contrast. Moreover, learned dynamic graphs can overfit noise without a stable anchor, causing false alarms or misses. To address these challenges, we propose the CGSTA framework with two key innovations. First, Dynamic Layered Graph Construction (DLGC) forms local, regional, and global views of variable relations for each sliding window; rather than contrasting whole windows, Contrastive Discrimination across Scales (CDS) contrasts graph representations within each view and aligns the same window across views to make learning structure-aware. Second, Stability-Aware Alignment (SAA) maintains a per-scale stable reference learned from normal data and guides the current window's fast-changing graphs toward it to suppress noise. We fuse the multi-scale and temporal features and use a conditional density estimator to produce per-time-step anomaly scores. Across four benchmarks, CGSTA delivers optimal performance on PSM and WADI, and is comparable to the baseline methods on SWaT and SMAP.