We apply transfer learning (TL) to construct data-driven models of inclusive electron-nucleus cross sections. Starting from an ensemble of deep neural networks pretrained on
12C data, we fine-tune the models separately for
3He,
6Li,
16O,
27Al,
40Ca, and
56Fe. The resulting models improve for all targets, marginally so for oxygen, where the carbon baseline is already adequate, although their predictive robustness depends on the amount, coverage, and precision of the available target data. We systematically study how model performance depends on the number of fine-tuned layers, on the fraction and selection of the training data, and on the overlap between the source and target kinematic domains. The layer-wise analysis shows that oxygen requires only shallow adaptation, whereas helium, calcium, and iron require substantially deeper fine-tuning. Lithium represents the least robust case because of its limited dataset, while aluminum demonstrates a strong sensitivity to a small subset of highly constraining measurements. For selected kinematic configurations outside the coverage of the carbon training data, the adapted models remain consistent with the measurements within their estimated uncertainties. Finally, we compare the resulting predictions with those of the phenomenological F1F2 model.