Onboard Artificial Intelligence can improve responsiveness and bandwidth efficiency of Earth Observation systems by processing data directly on the satellite. This paper presents the experience gained from the development, onboard integration, and post-launch adaptation of a lightweight marine anomaly detection pipeline deployed on the European Space Agency's
Φsat-2 mission. The application combines sea segmentation, self-supervised feature encoding of marine regions, generic anomaly detection based on deviations from a normal sea state, and optional characterization of selected anomaly types. Before launch, the pipeline was trained and validated on simulated
Φsat-2 imagery to assess algorithmic performance and compatibility with resource-constrained onboard hardware. After integration and functional validation in the mission environment, early experiments on real
Φsat-2 acquisitions revealed a significant mismatch between simulated and in-orbit data. The pipeline was therefore retrained on real Level-1 imagery using an improved annotation strategy to better handle ambiguous marine regions, substantially enhancing performance. Beyond demonstrating the onboard feasibility of the application, the
Φsat-2 experience highlights the importance of robust annotation strategies and sensor-aware design, and shows that simulation-based development is valuable for pre-flight risk reduction, while reliable scientific validation requires representative in-orbit data and should be clearly distinguished from functional validation.