physics.flu-dynFeb 17, 2026

Uni-Flow: a unified autoregressive-diffusion model for complex multiscale flows

Authors: Xiao Xue, Tianyue Yang, Mingyang Gao, Leyu Pan, Maida Wang, Kewei Zhu, Shuo Wang, Jiuling Li, +2 more

Organizations: Centre for Computational Science, University College London, London, UK · Department of Earth Science and Engineering, Imperial College London, London, UK · Department of Chemical Engineering, University College London, London, UK · Department of Physics, Eindhoven University of Technology, Eindhoven, Netherlands · School of Civil & Environmental Engineering, Queensland University of Technology, Brisbane, Australia · Australian Centre for Water and Environmental Biotechnology, The University of Queensland, Brisbane, Australia · Institute for Mechanics, Computational Mechanics Group, Technical University of Darmstadt, Germany · Centre for Advanced Research Computing, University College London, London, UK

Abstract

Spatiotemporal flows govern diverse phenomena across physics, biology, and engineering, yet modelling their multiscale dynamics remains a central challenge. Despite major advances in physics-informed machine learning, existing approaches struggle to simultaneously maintain long-term temporal evolution and resolve fine-scale structure across chaotic, turbulent, and physiological regimes. Here, we introduce Uni-Flow, a unified autoregressive-diffusion framework that explicitly separates temporal evolution from spatial refinement for modelling complex dynamical systems. The autoregressive component learns low-resolution latent dynamics that preserve large-scale structure and ensure stable long-horizon rollouts, while the diffusion component reconstructs high-resolution physical fields, recovering fine-scale features in a small number of denoising steps. We validate Uni-Flow across canonical benchmarks, including two-dimensional Kolmogorov flow, three-dimensional turbulent channel inflow generation with a quantum-informed autoregressive prior, and patient-specific simulations of aortic coarctation derived from high-fidelity lattice Boltzmann hemodynamic solvers. In the cardiovascular setting, Uni-Flow enables task-level faster than real-time inference of pulsatile hemodynamics, reconstructing high-resolution pressure fields over physiologically relevant time horizons in seconds rather than hours. By transforming high-fidelity hemodynamic simulation from an offline, HPC-bound process into a deployable surrogate, Uni-Flow establishes a pathway to faster-than-real-time modelling of complex multiscale flows, with broad implications for scientific machine learning in flow physics.

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