FLIM Networks with Bag of Feature Points

Pathology foundation models (FMs) are models trained on vast amounts of typically unlabeled data and have been shown to yield regularized latent spaces that can be used effectively in downstream classification tasks. This is also true for the classification of mitotic figures vs. other cells. However, it is so far unclear if the latent space of current FMs provides features that are discriminant and spatially suitably resolved to also serve as a backbone for dense object detection paradigms. In this work, we investigate this question for common current pathology FMs (UNI, UNI2-h, Virchow, Virchow2, H-optimus-0, H-optimus-1) and compare their performance against a fully end-to-end trained baseline based on a ResNet50 architecture. We combine FM backbones with representatives of single stage, dual stage and self-attention-based detectors (RetinaNet, Faster R-CNN, Deformable DETR respectively) on the multi-domain MIDOG++ dataset, and on the TUPAC16 dataset as an out-of-domain case. We show that the H-optimus-0 and Virchow models yielded competitive performance, indicating that the latent spaces of current FMs, all trained on image-level self-supervision, are suitable for direct mitotic figure detection and may be slightly more robust on our out-of-domain test case. All code is made available publicly at https://github.com/DeepMicroscopy/FM4MFdet.

Modern object detectors are static, fixed-depth networks optimized for a single operating point, requiring separate models for different deployment scenarios. We present an any-depth detection framework that enables a single network to span a continuous range of accuracy--efficiency trade-offs by controlling depth at inference time without retraining. Each backbone and neck stage is divided into an essential path, which always executes, and a skippable refinement path; this decomposition preserves the full multi-scale feature hierarchy at every depth configuration, unlike conventional early exiting that discards entire stages. To train such a network, jointly optimizing many sub-networks of varying depth introduces conflicting gradient signals. We address this via self-distillation between only the two extremes, with prediction-level and feature-level alignment losses that enforce stage-wise modularity, ensuring the outputs of each stage remain compatible regardless of the paths taken. Instantiated on RT-DETR and YOLOv12, our full-depth configurations match or surpass their respective SOTA baselines with negligible parameter overhead, while the most efficient configurations achieve up to $1.82\times$ speedup at a cost of only 2.0 AP, all from a single set of weights.

Based on the Distributed Convolutional Neural Network(DisCNN), a straightforward object detection method is proposed. The modules of the output vector of a DisCNN with respect to a specific positive class are positively monotonic with the presence probabilities of the positive features. So, by identifying all high-scoring patches across all possible scales, the positive object can be detected by overlapping them to form a bounding box. The essential idea is that the object is detected by detecting its features on multiple scales, ranging from specific sub-features to abstract features composed of these sub-features. Training DisCNN requires only object-centered image data with positive and negative class labels. The detection process for multiple positive classes can be conducted in parallel to significantly accelerate it, and also faster for single-object detection because of its lightweight model architecture.