Compact Task-Aligned Imitation Learning for Laboratory Automation

Scientific laboratories increasingly rely on AI systems to reason about experiments, but the physical act of doing science remains largely outside their reach. AI can help read literature, generate hypotheses, and plan protocols, yet the execution of those protocols at the bench still requires a human operator. Vision-Language-Action (VLA) models provide one possible interface between written protocols and robot execution, but existing policies are trained mostly on household and tabletop demonstrations and rarely encounter the instruments, transparent liquids, or fixed protocol workflows found in scientific laboratories. Closing this gap requires both laboratory-specific supervision and a unified learning framework that can accommodate the diverse robot embodiments used to execute experimental protocols. We therefore identify data and embodiment as central bottlenecks alongside model design. To address the data side, we build RoboGenesis, a simulation-based workflow and data engine that composes configured laboratory workflows from atomic skills, validates and filters rollouts, and exports structured demonstrations across supported robot profiles. On the policy side, we present LabVLA, trained with a two-stage recipe: FAST action token pretraining first makes the Qwen3-VL-4B-Instruct backbone action aware before any continuous control is learned, and flow matching posttraining then attaches a DiT action expert under knowledge insulation. On the LabUtopia benchmark, LabVLA achieves the highest average success rate among all evaluated baselines under both in-distribution and out-of-distribution settings.

Long-horizon precision manipulation in laboratory automation, such as pipette tip attachment and liquid transfer, requires policies that respect strict procedural logic while operating in continuous, high-dimensional state spaces. However, existing approaches struggle with reward sparsity, multi-stage structural constraints, and noisy or imperfect demonstrations, leading to inefficient exploration and unstable convergence. We propose a Keyframe-Guided Reward Generation Framework that automatically extracts kinematics-aware keyframes from demonstrations, generates stage-wise targets via a diffusion-based predictor in latent space, and constructs a geometric progress-based reward to guide online reinforcement learning. The framework integrates multi-view visual encoding, latent similarity-based progress tracking, and human-in-the-loop reinforcement fine-tuning on a Vision-Language-Action backbone to align policy optimization with the intrinsic stepwise logic of biological protocols. Across four real-world laboratory tasks, including high-precision pipette attachment and dynamic liquid transfer, our method achieves an average success rate of 82% after 40--60 minutes of online fine-tuning. Compared with HG-DAgger (42%) and Hil-ConRFT (47%), our approach demonstrates the effectiveness of structured keyframe-guided rewards in overcoming exploration bottlenecks and providing a scalable solution for high-precision, long-horizon robotic laboratory automation.

Vision-Language-Action (VLA) models provide a versatile foundation for general robotic manipulation, yet they exhibit significant brittleness when confronted with novel task distributions. While In-Context Imitation Learning (ICIL) offers a training-free alternative, existing frameworks suffer from an adaptation bottleneck that hinders the effective translation of expert context to executable actions. This failure originates from superficial retrieval mechanisms and an inherent behavioral inertia that anchors the policy to its pre-trained priors. To address these limitations, we present RA-VLA, a retrieval-augmented VLA framework that integrates behavior-aligned context retrieval with a grounded execution pipeline. By enforcing faithful adherence to functional cues within a scalable architecture, RA-VLA facilitates seamless task adaptation while preserving inference efficiency. Our empirical evaluations across the LIBERO benchmark and a real-world UR5e environment demonstrate that RA-VLA achieves superior success rates and computational efficiency, establishing a robust framework for training-free robotic adaptation.