A Hybrid Machine Learning Model for Cerebral Palsy Detection

Deep learning has shown significant potential in medical image analysis, particularly for disease detection using MRI scans. Accurate and early diagnosis of brain tumors remains challenging due to the complexity of brain structures and reliance on manual interpretation. This work presents an automated deep learning-based approach for brain tumor detection from MRI images using Convolutional Neural Networks and Residual Networks. Transfer learning is applied with two pretrained architectures, ResNet18 and ResNet50, to classify MRI scans into tumor and non-tumor categories. Experiments are conducted on a dataset of 3,929 brain MRI images, evaluating the impact of model depth and fine-tuning strategies. The results show that ResNet18 achieves a higher accuracy of 97% compared to 96% for ResNet50, demonstrating better generalization on limited medical data. The proposed framework enables fast, accurate, and cost-effective brain tumor detection, supporting early diagnosis and clinical decision-making.

Separating Alzheimer's Disease (AD), Parkinson's Disease (PD), and Healthy Controls (HC) using structural MRI remains challenging because disease signatures overlap and model performance can be strongly affected by data partitioning. We present HybridDualPathNet, a hybrid architecture combining EfficientNetV2-S for local features and Swin-Tiny for global context through a Cross-Fusion Attention (CFA) module. We evaluate the model in two experiments. First, on the Kaggle APD-3-Class dataset using an image-level split, the model achieves 98.25% accuracy. Second, on a combined Kaggle and Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset containing 17,859 slices, we use a per-source split with patient-wise separation for ADNI subjects. In this setting, the model achieves 73.37% standard accuracy and a macro AUC of 0.880. Source-stratified evaluation reveals a substantial domain gap, with 91.2% accuracy on Kaggle test images and 59.2% on ADNI test images. Temperature scaling reduces expected calibration error from 0.130 to 0.015, while split-conformal prediction achieves 89.5% coverage. Saliency analyses using Grad-CAM++, Integrated Gradients, and occlusion indicate that model activations concentrate on brain tissue. These results highlight the importance of patient-level separation, cross-dataset evaluation, and uncertainty estimation when assessing MRI classification systems. The findings also show that strong performance on a single dataset does not necessarily translate to reliable generalization across imaging cohorts.

This study introduces an automated deep learning framework for predicting brain injury (BI) in preterm infants from T2-weighted MRI (dHCP dataset). We propose GloResNet, a lightweight 3D CNN based on ResNet-10, pretrained on MedicalNet to address data scarcity. A global manifold mapping strategy first resamples each 3D volume to 128x128x128 and then applies subject-wise z-score intensity normalization, thereby preserving global topology while standardizing appearance. Training integrates mixup, class weighting, and test-time augmentation for robustness. In 5-fold cross-validation, GloResNet achieved 75.18% average accuracy (peak 81.82%), with specificity 0.81 and sensitivity 0.76. Results demonstrate that a topology-aware lightweight CNN has the capability to effectively predict neonatal BI, offering a non-invasive screening tool. The source code of this paper can be obtained from the GitHub repository: https://github.com/ICL-SUST/GloResNet-Preterm-Brain