Disentangle-then-Align: Non-Iterative Hybrid Multimodal Image Registration via Cross-Scale Feature Disentanglement

In multi-modal image registration, the primary challenge lies in shared structural information extraction. Compared to Transformers, Structured State Space Duality (SSD) offers greater global structural feature extraction with higher efficiency during training and inference. Inspired by these advantages, we propose a novel algorithm for multi-modal image registration, named RegNetMamba-2. Our algorithm incorporates SSD into coarse-to-fine matching process to extract local and global structural features effectively. Firstly, SSD is applied in three different scales for multi-modal feature extraction in our network. To strengthen local representation, we pay more attention on foreground edge and structural information by feature scaling function of SSD. Secondly, for shared feature extraction of input images and multi-modal feature fusion in all scales, we propose cross-modality feature fusion model based on SSD, consisting of Cross-Modality feature Interaction (CMI) module and Multi-Scale feature Fusion (MSF) module. CMI module is designed for cross-modality feature extraction of each scale by SSD in cross form. MSF module is designed to employ a progressive upward fusion in feature-level to obtain fine features, consisting of multi-modal features in all scales. Following coarse-to-fine, the features in 1/8 scale from CMI and 1/2 scale from MSF are collected to calculate matching probability scores. Then we respectively establish matching process by correspondences of pixel-wise. Extensive experiments demonstrate that comparing with state-of-the-art deep-learning based algorithms, RegNetMamba-2 has achieved good effects in both performance and efficiency for multi-modal image registration on the following datasets: VIS-SAR (OSDataset), VIS-IR (LGHD/RoadSence) and VIS-NIR (RGB-NIR sense).

We present Consistent-Recurrent Feature Flow Transformer (CRFT), a unified coarse-to-fine framework based on feature flow learning for robust cross-modal image registration. CRFT learns a modality-independent feature flow representation within a transformer-based architecture that jointly performs feature alignment and flow estimation. The coarse stage establishes global correspondences through multi-scale feature correlation, while the fine stage refines local details via hierarchical feature fusion and adaptive spatial reasoning. To enhance geometric adaptability, an iterative discrepancy-guided attention mechanism with a Spatial Geometric Transform (SGT) recurrently refines the flow field, progressively capturing subtle spatial inconsistencies and enforcing feature-level consistency. This design enables accurate alignment under large affine and scale variations while maintaining structural coherence across modalities. Extensive experiments on diverse cross-modal datasets demonstrate that CRFT consistently outperforms state-of-the-art registration methods in both accuracy and robustness. Beyond registration, CRFT provides a generalizable paradigm for multimodal spatial correspondence, offering broad applicability to remote sensing, autonomous navigation, and medical imaging. Code and datasets are publicly available at https://github.com/NEU-Liuxuecong/CRFT.

Deformable image registration remains a central challenge in medical image analysis, particularly under multi-modal scenarios where intensity distributions vary significantly across scans. While deep learning methods provide efficient feed-forward predictions, they often fail to generalize robustly under distribution shifts at test time. A straightforward remedy is full network fine-tuning, yet for modern architectures such as Transformers or deep U-Nets, this adaptation is prohibitively expensive in both memory and runtime when operating in 3D. Meanwhile, the naive fine-tuning struggles more with potential degradation in performance in the existence of drastic domain shifts. In this work, we propose a registration framework that integrates a frozen pretrained mono-modal registration model with a lightweight adaptation pipeline for multi-modal image registration. Specifically, we employ style transfer based on contrast-agnostic representation generation and refinement modules to bridge modality and domain gaps with instance optimization at test time. This design is orthogonal to the choice of backbone mono-modal model, thus avoids the computational burden of full fine-tuning while retaining the flexibility to adapt to unseen domains. We evaluate our approach on the Learn2Reg 2025 LUMIR validation set and observe consistent improvements over the pretrained state-of-the-art mono-modal backbone. In particular, the method ranks second on the multi-modal subset, third on the out-of-domain subset, and achieves fourth place overall in Dice score. These results demonstrate that combining frozen mono-modal models with modality adaptation and lightweight instance optimization offers an effective and practical pathway toward robust multi-modal registration.