Deformable Image Registration

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Overview

Deformable image registration finds spatial correspondences between images when structures move or change shape, supporting tasks such as longitudinal analysis, image-guided surgery, and radiotherapy dose accumulation. Methods include classical intensity- and feature-based optimization, spline or diffeomorphic deformation models, and learned CNN or transformer systems; newer approaches also use pretrained features, biomechanical priors, and test-time refinement. Researchers assess alignment with measures such as landmark target error and anatomical overlap, while also checking whether deformation fields are smooth, plausible, and useful for downstream tasks. A central challenge is that methods that perform well on one anatomy or modality may not generalize, and better overlap does not always mean reliable correspondences or safe clinical decisions.

Latest papers

CardsList

77 papers10 papers in the last four weeks, up 43% on the four weeks before. 0.1% of all new papers.

  1. Learning Where to Trust: Reliability-Guided Expert Routing and Velocity Gating for 3D Deformable Registration

    Oct 27, 2026Chenyu Guo, Wenjie Dai, Yiqian Chang +3Medical Image RegistrationDeformable Image Registration

    Harbin Institute of Technology, Shenzhen, Guangdong, China · Peng Cheng Laboratory, Shenzhen, Guangdong, China

  2. FlexiMIND: Combined Pretrained Vision Features and Local Structure for Training-Free Deformable Medical Image Registration

    Oct 25, 2026Mojtaba Safari, Mingzhe Hu, Shansong Wang +6Medical Image RegistrationDeformable Image Registration

    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, United States. · Department of Computer Science and Informatics, Emory University, Atlanta, GA, United States. · Department of Radiology, The University of Chicago, Chicago, IL, United States.

  3. ACorD: Adaptive Correspondence Discovery for Medical Image Registration

    Oct 19, 2026Arghavan Rezvani, Kun Han, Xiaohui XieMedical Image RegistrationDeformable Image Registration

    University of California, Irvine

  4. Landmark-Free and Scale-Blind Multi-View Registration of Preoperative Liver Models to Intraoperative Surfaces

    Oct 16, 2026Jiaming Feng, Gerardo Loza Galindo, Shahid Farid +1Medical Image RegistrationPoint Cloud Registration

    AI in Medicine and Surgery Group, School of Computer Science, University of Leeds, Leeds LS2 9JT, United Kingdom · Department of HPB and Transplant Surgery, St. James’s University Hospital, Leeds, United Kingdom

  5. LUMINR: Intensity-conditioned Meta-learned INRs for Accelerated Medical Image Registration

    Oct 16, 2026Damian Rynczak, Marek WodzinskiMedical Image RegistrationDeformable Image Registration

    AGH University of Krakow · Sano - Centre for Computational Personalised Medicine, International Research Foundation

  6. Temporal Periodic Image Registration with Implicit Neural Representations

    Oct 15, 2026Mathias Lowes, Kristine Aavild Sørensen, Maxime Sermesant +1Deformable Image RegistrationMedical Image Registration

    Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark · Novo Nordisk A/S, Copenhagen, Denmark · Inria Université Côte d’Azur, Nice, France

  7. PET Quantification-Preserving Registration for Longitudinal Whole-Body PSMA PET/CT

    Oct 15, 2026Fryderyk Kögl, Anna Reithmeir, Daniel M. Lang +3Medical Image RegistrationDeformable Image Registration

    Helmholtz Munich · Technical University of Munich · Munich Center for Machine Learning +2

  8. Really Need Recursion? Revisiting One-pass Registration with Multi-level Multi-space Contextual Guidance

    Oct 15, 2026Yue Lin, Shenghai Wu, Mingyuan MengMedical Image RegistrationDeformable Image Registration

    Zhongguancun Academy, Beijing, China. · Research Institute, Newland Digital Technology, Fuzhou, China.

  9. Registration is a Representation Problem: Solving Whole-Body PET/CT Registration

    Oct 13, 2026Neel Dey, Adrian V. DalcaMedical Image RegistrationDeformable Image Registration

    A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital · Department of Radiology, Harvard Medical School · Computer Science and AI Lab, Massachusetts Institute of Technology

  10. Personalising Deformable Image Registration with Clinical Context and Deformation History for Adaptive Radiotherapy

    Oct 13, 2026Caiwen Jiang, Songlin Zhao, Yuzhen Ding +23Medical Image RegistrationDeformable Image Registration

    Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA · School of Biomedical Engineering, ShanghaiTech University, Shanghai, China · Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA +2

  11. Deformable CT-US Registration via Anatomy-Aware Implicit Neural Representations

    Oct 6, 2026Agnieszka Lach, Magdalena Wysocki, Feng Li +7Medical Image RegistrationUltrasound Imaging

    medPhoton GmbH, Salzburg, Austria · Computer Aided Medical Procedures, Technical University of Munich, Munich, Germany

  12. Universal Drift Correction for Multidimensional Scanning Microscopy

    Sep 25, 2026Sangjoon Lee, William Millsaps, Dasol Yoon +7Microscopy Image AnalysisDeformable Image Registration

    Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA · Stanford Nano Shared Facilities, Stanford University, Stanford, CA 94305, USA

  13. Recursive Uncertainty-Gated Image Registration for Learning-based Algorithms

    Sep 23, 2026Clara Rodrigo González, Oscar Bates, Fu Siong Ng +1Medical ImagingMedical Image Registration

    Department of Bioengineering, Imperial College London, London, UK · Department of Earth Science and Engineering, Imperial College London, London, UK · National Heart and Lung Institute, Imperial College London, London, UK

  14. Evaluating Transformation Models for pCLE Mosaic Registration

    Sep 21, 2026Ahmed Aboelela, Johannes Barcsay, Jana Friedhof +3Medical ImagingMedical Image Registration

    Center for Artificial Intelligence and Data Science (CAIDAS), Julius-Maximilians-Universität Würzburg, Würzburg, Germany · Department of Internal Medicine II, Interventional and Experimental Endoscopy (InExEn), University Hospital Würzburg, Würzburg, Germany · Department of Otorhinolaryngology, Plastic and Aesthetic Operations, University Hospital Würzburg, Würzburg, Germany

  15. BINDER: A Latent Variable Model for Probabilistic Medical Image Registration

    Sep 17, 2026Stefano Cerri, Amirhossein Hassankhani, Yaël Balbastre +1Medical Image RegistrationCross-Modal Image Registration

    Copenhagen Research Centre for Biological and Precision Psychiatry, Mental Health Centre Copenhagen, Copenhagen University Hospital, Denmark, and the Pioneer Centre for Artificial Intelligence, University of Copenhagen, Denmark · Department of Neuroscience and Biomedical Engineering, Aalto University, Finland · Department of Experimental Psychology, Division of Psychology and Language Sciences, University College London +1

  16. Benchmarking Intra-Patient 3D Deformable Multimodal Image Registration

    Sep 14, 2026Matteo Barbieri, Giammarco La Barbera, Juan Pablo De La Plata +3Medical Image RegistrationCross-Modal Image Registration

    IMAG2, Institut IMAGINE, Université Paris Cité, Paris, France · Replico SAS, Paris, France · Université Paris Cité, Department of Pediatric Surgery, Hôpital Necker Enfants-Malades, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France +2

  17. Fast and Accurate Monomodal 3D High Resolution Deep Registration of Drosophila Larval Brain Volumes

    Sep 10, 2026Daniel Reisenbüchler, Yousef Sadegheih, Michael Dittrich +3Medical Image RegistrationNeuroimaging

    Faculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany. · Fraunhofer Institute for Digital Medicine, MEVIS, Bremen, Germany.

  18. Two-Parameter Flow Map Learning for Continuous-Time Diffeomorphic Image Registration

    Sep 9, 2026Mohammadjavad Matinkia, Nilanjan RayMedical Image RegistrationFlow Map Learning

    University of Alberta, Canada

  19. Coronary Mask Guided Registration for Continuous Time 4D Cardiac CT Dataset Construction

    Aug 28, 2026Yuang Wang, Shuo Wang, Changyu Chen +124D ReconstructionMedical Image Registration

    Department of Engineering Physics, Tsinghua University, Beijing 100084, China · Department of Radiology, The Ohio State University, 2050 Kenny Rd, Columbus, OH 43221, Ohio, USA · Center for Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, 399 Revolution Dr, Somerville, 02145, Massachusetts, USA +2

  20. Is Deformable Image Registration Ready for Brain Metastasis Reirradiation Dose Accumulation? A Longitudinal MRI Benchmark of Registration Accuracy

    Aug 27, 2026Hengjie Liu, Manju Sharma, Xinyi Fu +2Deformable Image RegistrationMedical Image Benchmarks

    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA

  21. Phase-Aligned Finite-Fourier Periodic Deformation for 4D Medical Image Interpolation

    Aug 25, 2026Haojin Li, Hengzhuo Wang, Zhiheng Ma +34D ReconstructionDeformable Image Registration

    School of Computer Science and Engineering Beihang University Beijing, China

  22. Low-Rank Velocity Fields as a Structural Prior for Unsupervised 4D Medical Image Interpolation

    Aug 25, 2026Haojin Li, Hengzhuo Wang, Chang Liu +3Medical Image Synthesis4D Reconstruction

    Department of Computer Science and Engineering, Southern University of Science and Technology, Shenzhen, China · Faculty of Biomedical Engineering, Shenzhen University of Advanced Technology, Shenzhen, China · School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China +2

  23. Architectural and Regularization Components in Deep Learning Medical Image Registration: Systematic Ablation Study

    Aug 23, 2026Nabira RashidMedical Image RegistrationDeformable Image Registration

    Carnegie Mellon University · Harvard Medical School

  24. Self-Calibrating Dense Displacement Fields for Reliable Co-Registration of Large Optical Satellite Imagery

    Aug 23, 2026Shoukun Sun, Zhe Wang, Sanaz Salati +3Deformable Image RegistrationImage Matching

    Department of Computer Science, University of Idaho, Moscow, ID 83844 USA · National Center for Ecological Analysis and Synthesis (NCEAS), University of California, Santa Barbara, CA 93101 USA · Research Computing and Data Services (RCDS), University of Idaho, Moscow, ID 83844 USA +1

  25. The Right Prior for the Right Deformation: Rethinking Continuous Deformable Image Registration

    Aug 17, 2026Hengjie Liu, Chushu Shen, Dan Ruan +1Medical Image RegistrationDeformable Image Registration

    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA · Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA · Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA +1

  26. Modality-Invariant Coarse-to-Fine Retinal Image Registration

    Aug 14, 2026Bo Wen, Nehal Nailesh Mehta, Melanie Tran +3Medical Image RegistrationCross-Modal Image Registration

  27. DisMorph\texttt{DisMorph}: learning to disentangle technical distortions from true biological change

    Aug 8, 2026Jingru Fu, Kathleen E. Larson, Douglas N. Greve +2Longitudinal Medical Image AnalysisMedical Image Registration

    Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, USA · Department of Radiology, Massachusetts General Hospital, Boston, USA · Department of Radiology, Harvard Medical School, Boston, USA

  28. An Accessible Solution for Deformable Image Registration Compared with Learning-Based Approaches

    Aug 3, 2026Onur Ali Zeybekoglu, David Tilly, Orcun GokselMedical Image RegistrationDeformable Image Registration

    Department of Information Technology, Uppsala University, Uppsala, Sweden · Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden · Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

  29. Vis2Reg: Visibility-Aware Landmark-Free Geometric 3D--2D Registration for Liver Laparoscopy

    Jul 20, 2026Jiaming Feng, Xukun Zhang, Shahid Farid +1Medical Image RegistrationDeformable Image Registration

    AI in Medicine and Surgery Group, School of Computer Science, University of Leeds, LS2 9JT, Leeds, United Kingdom · Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong · Department of HPB and Transplant Surgery, St. James’s University Hospital, Leeds, United Kingdom

  30. DINE: Distance Is Not Enough -- Learning Global Deformation Priors for Robust Soft-Tissue Point Cloud Registration

    Jul 16, 2026Sara Monji-Azad, Rohit Beer, Marvin Kinz +2Medical Image RegistrationPoint Cloud Registration

    Mannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany · Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA · Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany +4