Scaling Whole-Body Human Musculoskeletal Behavior Emulation for Specificity and Diversity

Learning motor control for muscle-driven musculoskeletal models is hindered by the computational cost of biomechanically accurate simulation and the scarcity of validated, open full-body models. Here we present MuscleMimic, an open-source framework for scalable motion imitation learning with physiologically realistic, muscle-actuated humanoids. MuscleMimic provides two validated musculoskeletal embodiments - a fixed-root upper-body model (126 muscles) for bimanual manipulation and a full-body model (416 muscles) for locomotion - together with a retargeting pipeline that maps SMPL-format motion capture data onto musculoskeletal structures while preserving kinematic and dynamic consistency. Leveraging massively parallel GPU simulation, the framework achieves order-of-magnitude training speedups over prior CPU-based approaches while maintaining comprehensive collision handling, enabling a single generalist policy to be trained on hundreds of diverse motions within days. The resulting policy faithfully reproduces a broad repertoire of human movements under full muscular control and can be fine-tuned to novel motions within hours. Biomechanical validation against experimental walking and running data demonstrates strong agreement in joint kinematics (mean correlation r = 0.90), while muscle activation analysis reveals both the promise and fundamental challenges of achieving physiological fidelity through kinematic imitation alone. By lowering the computational and data barriers to musculoskeletal simulation, MuscleMimic enables systematic model validation across diverse dynamic movements and broader participation in neuromuscular control research. Code, models, checkpoints, and retargeted datasets are available at: https://github.com/amathislab/musclemimic

Musculoskeletal (MSK) humanoids provide a physiologically grounded embodiment for studying full-body motor control, but their high-dimensional muscle actuation, delayed activation dynamics, and redundant muscle--tendon structures make learning substantially harder than torque-driven humanoid control. Existing MSK benchmarks remain fragmented across gait, prosthetics, dexterous hands, or challenge-specific tracks, leaving full-body muscle-actuated control insufficiently evaluated under standardized tasks, methods, and metrics. We introduce MSK-Bench, a benchmark of 22 full-body motor-control tasks organized into three progressively challenging categories: postural stabilization, common locomotor behaviors, and contact-rich environmental interaction. Under unified task protocols and robustness perturbations, MSK-Bench evaluates 5 representative control paradigms, including reward-based RL, agentic reward tuning, latent-action RL, imitation-prior control, and residual adaptation over imitation priors. Beyond task success and reward, MSK-Bench further reports robustness analysis and physiology-oriented diagnostics, including activation cost, joint smoothness, and EMG-envelope similarity. Our empirical study shows that embodiment-aware exploration and structured action representations improve task coverage in high-dimensional muscle spaces, imitation priors enhance reference-compatible stabilization and locomotion but degrade under contact-rich terrain mismatch, and residual adaptation can recover successful behaviors when fixed references fail. We further find that improved task success does not necessarily imply improved physiological agreement, highlighting the importance of evaluating task performance, robustness, and physiological behavior jointly. MSK-Bench provides a task--method--metric testbed for full-body muscle-actuated humanoid control.

Building a general-purpose whole-body controller is essential for enabling diverse motion capabilities in humanoid robots across a wide range of downstream tasks, including locomotion and loco-manipulation. Different tasks rely on distinct motion reference modalities: locomotion primarily depends on coordinated robot joint trajectories, whereas manipulation requires precise end-effector trajectory tracking. Existing methods often overlook the representational mismatch between dense robot joint angles and sparse end-effector poses. To address this, we propose Multi-Modal Mimic (M3imic), a versatile multi-modal whole-body control framework that unifies heterogeneous motion reference modalities, including robot joint angles, human pose trajectories, and end-effector poses, using modality-specific encoders to map them into a shared latent space. Leveraging large-scale reinforcement learning in the simulator, we train a single policy that achieves sim-to-real transfer across multiple motion reference modalities without modality-specific retraining. Extensive simulation and real-world experiments on the Unitree G1 robot are conducted to evaluate the proposed framework. In simulation, the policy achieves a peak success rate of 98.42% on an unseen test dataset, demonstrating its exceptional generalization capability. The code is available at https://github.com/Renforce-Dynamics/MultiModalWBC