Explainable Machine Learning Reveals 12-Fold Ucp1 Upregulation and Thermogenic Reprogramming in Female Mouse White Adipose Tissue After 37 Days of Microgravity: First AI/ML Analysis of NASA OSD-970

Earth s gravity fundamentally shapes human behaviour. The brain encodes this force as an internal model of gravity, enabling the prediction and interpretation of gravitational effects during perception and action. Understanding how this model adapts to altered gravity is critical for predicting human performance in spaceflight. We present a computational framework for modelling neurophysiological adaptation across diverse gravitational environments. The framework has two components trained on open-access data from altered-gravity studies, particularly parabolic flights. The first component (CorticalG) employs a lightweight multilayer perceptron neural network to predict gravity-dependent changes in EEG frequency bands, estimating cortical state under different gravitational loads. The second component (PhysioG) uses independent Gaussian process models to capture broader physiological responses, including heart rate variability, electrodermal activity, and motor control. To complement the quantitative modelling, we simulated subjective experience across gravitational environments using the Large Language Model (LLM) Claude 3.5 Sonnet. Physiological outputs prompted the model to generate narratives describing alertness, bodily awareness, and cognitive state across zero gravity, partial gravity of the Moon and Mars, and hypergravity. This framework provides a novel approach for investigating human adaptation to spaceflight. It offers a predictive tool to assess performance and resilience, supporting the design of future space exploration missions.

Diabetes mellitus affects over 537 million adults worldwide and remains a major challenge in preventive healthcare. Existing machine-learning studies primarily formulate diabetes prediction as a binary classification problem, while subtype-oriented analysis and glycaemic-cognitive associations remain comparatively underexplored. We present a reproducible three-stage machine learning framework for diabetes detection, subtype-oriented clustering, and metabolic-cognitive association analysis. In Stage 1, five supervised classifiers together with a stacking ensemble are benchmarked on the NCSU Diabetes Dataset using stratified five-fold cross-validation and evaluation metrics including ROC-AUC, balanced accuracy, recall, and F1-score. SVM-RBF and Logistic Regression achieve the highest ROC-AUC ($0.825 \pm 0.026$), while Random Forest achieves the highest accuracy ($0.762 \pm 0.030$). SHAP explainability identifies Glucose, BMI, and Age as the dominant predictive biomarkers. In Stage 2, silhouette-validated K-Means clustering ($k=2$, silhouette $\approx 0.116$) is applied to confirmed diabetic cases using Glucose, Insulin, and Age, recovering clinically plausible subtype-oriented partitions without requiring ground-truth subtype labels. In Stage 3, statistical analysis of the Ohio Longitudinal Cognitive Dataset ($n=373$) reveals a significant positive association between glycaemic control and cognitive function ($ρ_s = 0.208$, $p = 5.29 \times 10^{-5}$), which survives Holm correction. The findings support the utility of statistically grounded and interpretable ML pipelines for reproducible diabetes analytics and subtype-aware exploratory analysis.

Autonomous space systems operating in extreme thermal environments require accurate and efficient thermal modeling to support both pre-mission system design and onboard autonomy. For lunar rovers, large temperature gradients, radiative heat transfer, and variable surface conditions make reliable thermal prediction especially challenging. High-fidelity physics-based simulations provide accurate results but are computationally expensive, while simplified models and lookup-table approach often lack sufficient accuracy. Physics-informed machine learning (PIML) offers a promising alternative by combining data-driven models with embedded physical knowledge. This paper presents a PIML framework for thermal analysis of a simplified lunar rover with internal heat sources, where machine learning enables environment-adaptive coarse meshing. The proposed architecture integrates a transfer neural network (TNN) that adaptively determines 3D finite-difference nodalization based on thermal loads and initial conditions, enabling more accurate coarse-mesh calculations. A differentiable finite-difference thermal simulator is embedded within the framework to enforce physical consistency and support efficient training, while an upscaling layer reconstructs high-resolution temperature fields from the coarse-grid solution. The proposed PIML approach is evaluated against high-fidelity fine-mesh simulations, low-fidelity fixed coarse-mesh models, and a purely data-driven artificial neural network (ANN). Results show that the PIML framework improves prediction accuracy by 50% and 39% relative to the coarse-mesh physics model and ANN model, respectively, while maintaining physically consistent thermal distributions. Computationally, the framework is also 3x faster than high-fidelity simulations, demonstrating an effective balance between accuracy and efficiency for thermal modeling of lunar rover systems.