Adaptive Dual Residual U-Net with Attention Gate and Multiscale Spatial Attention Mechanisms (ADRUwAMS)

Brain cancer's severity necessitates precise brain tumor segmentation, which is crucial for effective brain tumor diagnosis. Manual identification, burdened by high costs, labor, and error risks, highlights the need for automated methods. In this study, we introduce the Global Context-aware Squeeze and Excite Residual UNet (GCSER-UNet), which facilitates a fusion of spatial and channel-wise attention and thus enhances the model's capacity to capture intricate spatial dependencies and contextual information. GCSER-UNet efficiently extracts tumor segments from multimodal MRI slices, delivering exceptional performance. Evaluations on benchmark databases exhibit its superiority, achieving a notable 94 percent dice score on the TCGA LGG dataset, surpassing the state-of-the-art dice score of 91.8 percent. In the BraTS 2020 dataset, the proposed GCSER-UNet ensemble approach yielded dice scores of 95 percent, 92 percent, and 90 percent for the tumor regions - Whole Tumor (W), Tumor Core (T), and Enhancing Tumor (E), respectively. The current state-of-the-art dice scores were 94 percent, 93 percent, and 88 percent. These compelling outcomes highlight the efficacy of GCSER-UNet in precise brain tumor segmentation and thus can aid neurologists in effective brain cancer management and treatment planning.

Computer-aided segmentation of brain tumors from MRI data is of crucial significance to clinical decision-making in diagnosis, treatment planning, and follow-up disease monitoring. Gliomas, owing to their high malignancy and heterogeneity, represent a very challenging task for accurate and reliable segmentation into intra-tumoral sub-regions. Manual segmentation is typically time-consuming and not reliable, which justifies the need for robust automated techniques.This research resolves this problem by leveraging the BraTS 2020 dataset, where we have labeled MRI scans of glioma patients with four significant classes: background/healthy tissue, necrotic/non-enhancing core, edema, and enhancing tumor. In this work, we present a new segmentation technique based on a U-Net model augmented with executed attention gates to focus on the most significant regions of images. To counter class imbalance, we employ manually designed loss functions like Dice Loss and Categorical Dice Loss, in conjunction with standard categorical cross-entropy. Other evaluation metrics, like sensitivity and specificity, were used to measure discriminability of the model between tumor classes. Besides, we introduce Grad-CAM-based explainable AI to enable visualizing attention regions and improve model interpretability, together with a smooth heatmap generation technique through Gaussian filtering. Our approach achieved superior performance with accuracy of 0.9919, Dice coefficient of 0.9901, mean IoU of 0.9873, sensitivity of 0.9908, and specificity of 0.9974. This study demonstrates that the use of attention mechanisms, personalized loss functions, and explainable AI significantly improves highly complex tumor structure segmentation precision in MRI scans, providing a reliable and explainable method for clinical applications.

Gliomas are among the most aggressive cancers, with complex diagnostic processes. Existing glioma segmentation methods often struggle with high variability in imaging data and inadequate optimization. Furthermore, radiomic analysis is typically applied only after segmentation is finished, limiting its ability to inform the segmentation process itself. To address these challenges, we propose a novel radiomics-enhanced fused residual multiparametric 3D network (ReFRM3D) for brain tumor characterization. The framework is based on a 3D U-Net architecture and features multi-scale feature fusion, hybrid upsampling, and an extended residual skip mechanism. Additionally, we introduce a radiomic conditioning mechanism that extracts texture and intensity descriptors from an intermediate coarse segmentation and re-injects them into the decoder to refine the final output. Experimental results on BraTS2019, BraTS2020, and BraTS2021 show strong performance, with mean DSC values of 93.45%, 93.61%, and 92.06%, respectively, across whole tumor, enhancing tumor, and tumor core regions. Compared with recent models, ReFRM3D improves average DSC by 5.79%, 7.25%, and 0.96% on these datasets. Our model also generalized well on the BraTS-Africa dataset with an average DSC of 87.8%, despite differences in scanner field strength and patient demographics.