Selective Token-Level Cryptographic Redaction for Privacy-Preserving Clinical Deployment of Large Language Models
Authors: Farhan Sheth, Ziyuan Yang, Yongying Lan, Si Yong Yeo
Organizations: MedVisAI Lab, Singapore · Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore · Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China
Abstract
While large language models (LLMs) are increasingly used for clinical applications, many existing pipelines require sending raw sensitive health information to remote servers for processing, which heightens the risk of privacy leakage. A natural approach to mitigate this risk is to encrypt the data before transmission. However, straightforward solutions such as encrypting the entire dataset introduce prohibitive computational, alignment, and communication overheads, rendering large-scale practical deployment infeasible. To preserve privacy while maintaining usability, we present Healthcare Encryption & Redaction via Adaptive Linguistic Decomposition (HERALD), a token-level cryptographic redaction framework designed to achieve this balance by encrypting only sensitive tokens while preserving the surrounding context for downstream model utility. HERALD combines medical named-entity recognizer (NER) with part-of-speech (POS) driven policies to select candidate tokens, performs targeted lemmatization to stabilize surface forms, and substitutes each protected token with a deterministic ciphertext wrapped in explicit delimiters. Notably, HERALD is model-agnostic and operates entirely on the client side, ensuring that sensitive content remains encrypted throughout storage, transmission, and processing without requiring changes to downstream models. We evaluated HERALD on both classification and medical question answering (MQA) tasks on public datasets. Across different tasks, experiments illustrate that fully secured baselines suffer significant utility loss, whereas HERALD consistently recovers performance close to plaintext. Overall, HERALD provides a novel utilization pipeline.
Medical language models (LMs) can memorize and reproduce protected health information, but privacy evaluations often focus on recovery of training text rather than disclosure under realistic threat models. We introduce a clinically grounded framework that evaluates leakage along a graded axis of adversarial access, ranging from publicly inferable demographics to leaked note fragments. At each tier, we measure verbatim memorization of patient-specific text and semantic leakage of sensitive diagnoses. Applying the framework to an LM pretrained on 378k clinical notes, we find that routine encounter metadata (i.e. name, date of birth, provider, practice, visit date) elicits high rates of verbatim memorization across a patient's timeline and sensitive-diagnosis recovery (AUROC 0.91 for abortion, 0.81 for HIV). At the same time, exact-match memorization can overstate disclosure: 36% of memorized tokens reflect templated documentation. Our work highlights the risks of training on longitudinal clinical data, providing a practical framework for contextual privacy evaluation of medical LMs.
De-identification of clinical text is a prerequisite for the secondary use of electronic health records. Existing public benchmarks such as the i2b2 2006 and 2014 corpora are over a decade old and lack the semantic and demographic diversity of modern clinical narratives. Large Language Models (LLMs) reach state-of-the-art zero-shot extraction, but their use at enterprise scale is limited by computational cost and by hospital data governance that restricts sending Protected Health Information (PHI) to cloud APIs. We introduce SHIELD (Synthetic Human-annotated Identifier-replaced Entries for Learning and De-identification), a diverse clinical note dataset of 1,381 notes with 10,229 gold-standard PHI spans across 9 categories, built with set-cover diversity sampling across demographic and document-type strata and human-in-the-loop adjudication. We evaluate four LLMs (two proprietary, two open-weight) to establish a performance ceiling on SHIELD, then show that a teacher-student distillation framework transfers these capabilities into locally deployable Small Language Models. Our best distilled model reaches micro-averaged span-level precision of 0.89 and recall of 0.88 while running on standard workstation hardware. It trails its cloud teacher on per-category recall (0.90 vs. 0.81 macro-averaged) but remains competitive given its lower cost and on-premise deployability. Cross-dataset evaluation shows that diversity-trained models generalize well on universal structured PHI categories, while institution-specific entities remain hard to transfer in both directions, which suggests pairing broad-coverage models with specialized models for high-volume, semi-structured note types. We publicly release the SHIELD dataset and the distilled DeBERTa v3 model to provide an accurate, cost-effective de-identification pipeline deployable entirely behind institutional firewalls.
Large language models (LLMs) are increasingly deployed in high-stakes domains, yet a unified treatment of their overlapping safety challenges remains lacking. We present SafeLM, a framework that jointly addresses four pillars of LLM safety: privacy, security, misinformation, and adversarial robustness. SafeLM combines federated training with gradient smartification and Paillier encryption for privacy, integrates defenses against training and inference-time attacks, employs contrastive grounding with calibrated decoding to reduce hallucinations, and introduces alignment-aware binarized aggregation to enhance robustness while maintaining bounded reconstruction quality. Across benchmarks on factuality, toxicity, and membership inference, SafeLM achieves 98.0% harmful content detection accuracy, reduces communication by 96.9%, and lowers gradient inversion PSNR from 31.7 dB to 15.1 dB. Ablations show that each component contributes independently, whereas their integration yields a strong privacy utility efficiency trade-off for deploying trustworthy LLMs.