Existing multi-agent LLM orchestration methods, ranging from brute-force ensembles to learned routers, select models and topologies based on task and model features. However, these methods do not consider the runtime state of the serving infrastructure. On shared GPU clusters under concurrent load, this infrastructure blindness causes systematic resource underutilization: preferred models accumulate deep request queues while equally capable alternatives sit idle. In multi-agent pipelines, where each query triggers multiple sequential model calls, these delays then compound across every downstream step. Closing this gap is challenging because the relevant infrastructure signals (queue depths, KV-cache pressure, latencies) are dynamic and noisy, and they must drive three different decisions: planning, per-step routing, and scheduling. We introduce INFRAMIND, a framework that makes the entire multi-agent stack infrastructure-aware. An infra-aware planner conditions topology and role selection on real-time system load and remaining budget, biasing toward simpler graphs under congestion and richer ones at low load. An infra-aware executor then observes per-model queue depths, cache utilization, and response latencies at each agent step to decide which model to call and how deeply to reason; a budget-aware scheduler further reorders each model's queue so that urgent requests are served first. Cast as a hierarchical constrained MDP and solved end-to-end via reinforcement learning, the system learns to balance quality against latency automatically. Across five benchmarks, INFRAMIND delivers up to +7.6 pp accuracy over the prior baseline at low load with up to 7x lower latency, and sustains up to 99.9% SLO compliance under high load where every baseline drops below 50%.
Multi-agent systems (MAS) coordinate multiple LLM-powered agents through structured workflows, gaining reasoning power but incurring high inference latency from multi-step execution and repeated model invocations. Existing orchestration methods primarily optimize task performance and inference cost, leaving latency largely unaddressed. In MAS, end-to-end latency is governed by the critical execution path, so reducing total cost alone does not reliably reduce latency. Moreover, optimizing latency while preserving accuracy remains non-trivial: naive latency optimization can misassign operator-level credit and degrade task accuracy. To address this gap, we propose Latency-Aware Multi-agent System (LAMaS), a latency-aware orchestration framework for learning-based multi-agent systems. LAMaS addresses this challenge at two levels: at training time, it learns latency-aware execution graphs through constrained optimization with critical-path-aware credit assignment; at inference time, since a graph committed at training time cannot exploit runtime evidence, it complements graph construction with a lightweight controller that adaptively eliminates redundant future agent interactions as execution unfolds. Experiments on four benchmarks show that LAMaS achieves the best latency among evaluated learning-based MAS baselines, reducing end-to-end latency by over 50% while maintaining competitive or better accuracy. LAMaS is also modular and transfers to other MAS with minimal changes, consistently yielding latency reductions.
As LLM applications grow more complex, developers are increasingly adopting multi-agent architectures to decompose workflows into specialized, collaborative components, introducing structure that constrains agent behavior and exposes useful semantic predictability. Unlike traditional LLM serving, which operates under highly dynamic and uncertain conditions, this structured topology enables opportunities to reduce runtime uncertainty\unicodex2015yet existing systems fail to exploit it, treating agentic workloads as generic traffic and incurring significant inefficiencies. Our analysis of production traces from an agent-serving platform and an internal coding assistant reveals key bottlenecks, including low prefix cache hit rates, severe resource contention from long-context requests, and substantial queuing delays due to suboptimal scaling. To address these challenges, we propose Pythia, a multi-agent serving system that captures workflow semantics through a simple interface at the serving layer, unlocking new optimization opportunities and substantially improving throughput and job completion time over state-of-the-art baselines.
Mixture-of-Agents (MoA) systems improve reasoning accuracy by routing each query to multiple expert LLMs and aggregating their outputs. Efficiently executing this workload on limited GPU resources has bottlenecks. Skill-based routing creates skewed expert demand, and combining instruction-tuned LLMs with long-reasoning models results in extreme variability in generation lengths. Consequently, traditional scheduling strategies suffer from significant GPU idling and throughput collapse due to load imbalances. We present MOSAIC, a scheduling framework to accelerate MoA workloads. First, we formulate an Integer Linear Program (ILP) based scheduler that jointly optimizes expert placement and per-worker prompt assignment from offline-profiled costs, replicating reasoning experts across workers while pinning lightweight ones. Second, MOSAIC uses confidence-aware adaptive aggregation, leveraging inter-expert agreement to bypass the heavy final aggregator LLM for consensus queries. In our 4-GPU system, MOSAIC achieves up to 2.5x expert-stage, 4.23x aggregator-stage and 1.7~2.3x end-to-end speedups over the baseline scheduler, while matching accuracy within 0.1pp.