The rapid growth of the global aging population presents severe challenges to healthcare systems, necessitating efficient, equitable, and patient-centered care models. While Industrial Engineering and Operations Research (OR) provide robust optimization and decision-support tools to address these multidimensional complexities, current applications often remain fragmented. This paper presents a thematic review of 30 seminal studies at the intersection of OR and elderly care, categorizing the literature into home healthcare operations, polypharmacy management, and clinical chronotherapy. Our analysis highlights a significant methodological evolution from static, deterministic models toward dynamic and stochastic frameworks integrated with artificial intelligence (AI). Despite these advancements, a critical translational gap persists: the current OR literature is heavily dominated by process-level optimizations, such as staff routing, and struggles to translate these operational efficiencies into measurable clinical outcomes. Furthermore, holistic models bridging the transition between hospital and community care remain critically underexplored. To develop resilient and smart healthcare systems, this study proposes a conceptual framework that shifts the research focus from isolated operational tasks to integrated, multi-level decision-making. We emphasize the critical need for robust systems analysis, human-inclusive design, and the smartification of care through emerging digital technologies - including digital twins and large language models - to successfully bridge the gap between theoretical operational metrics and tangible patient-level health outcomes.
Demand for older-adult and patient care is growing rapidly as populations age worldwide. Foundation models are increasingly being integrated into robots and interactive agents, with the promise of more flexible communication and personalized assistance. However, care settings require reliable and workflow-compatible systems with accountable human oversight, and it remains unclear whether current embodied systems can translate technical advances into clinical impact. This Perspective synthesizes foundation model-based care robots across three areas: design features, user experience, and evidence for care-related outcomes. Current systems most commonly use foundation models as conversational and reasoning layers within voice-centered socially assistive embodiments, while multimodal grounding and physical autonomy remain limited. Empirical evaluations report positive usability and engagement benefits, but reliability failures persist across the interaction pipeline such as hallucinations and conversational breakdowns. Evidence for care impact remains concentrated in proximal outcomes such as cognitive engagement and participation, with limited evidence for validated clinical or care-related changes. We argue that future research should transition toward care-specific evaluation standards, accountable autonomy, and integration into care workflows to support more responsive and responsible care technologies.
The growing demand for real-time, data-driven decision-making in complex and dynamic systems is placing increasing pressure on traditional Operational Research (OR) methodologies. Reinforcement learning (RL) has emerged as a complementary approach, offering strong learning and computational capabilities for sequential decision-making in dynamic and uncertain environments. Recent research shows an increasing interest in integrating RL with OR to address dynamic decision-making problems, enhance heuristic and exact methods for combinatorial optimization, and support the development of digital replicas of operational systems. The overarching goal across these efforts is to leverage the learning capabilities of RL to strengthen traditional OR algorithms, improving solution quality, computational efficiency, and robustness. Given the diversity of integration approaches and application settings, there is a clear need for a systematic and technically detailed review of how RL empowers OR methods. To address this gap, this paper presents a structured review of three key roles that RL plays in empowering OR: (i) solving sequential decision-making problems in dynamic environments, (ii) serving as an end-to-end solution method or as a component integrated within heuristic and exact OR methods for combinatorial optimization problems, and (iii) facilitating extended reality analysis through integration with digital twin systems. We critically synthesize recent advances across these roles, highlighting their advantages, implementation requirements, limitations, and challenges. Finally, based on these insights, we outline a roadmap for future research to further advance the methodological and practical integration of RL and OR.
As the reasoning capabilities of Large Language Models (LLMs) continue to advance, LLM-based agent systems offer advantages in flexibility and interpretability over traditional systems, garnering increasing attention. However, despite the widespread research interest and industrial application of agent systems, these systems, like their traditional counterparts, frequently encounter anomalies. These anomalies lead to instability and insecurity, hindering their further development. Therefore, a comprehensive and systematic approach to the operation and maintenance of agent systems is urgently needed. Unfortunately, current research on the operations of agent systems is sparse. To address this gap, we have undertaken a survey on agent system operations with the aim of establishing a clear framework for the field, defining the challenges, and facilitating further development. Specifically, this paper begins by systematically defining anomalies within agent systems, categorizing them into intra-agent anomalies and inter-agent anomalies. Next, we introduce a novel and comprehensive operational framework for agent systems, dubbed Agent System Operations (AgentOps). We provide detailed definitions and explanations of its four key stages: monitoring, anomaly detection, root cause localization, and resolution.