ChemWorld: Programmable Chemical Worlds for Controlled and Replayable Agent Experimentation

AI is evaluated through knowledge, reasoning and plan generation, yet scientific agency requires reliable physical action and adaptation to evidence. Here, we use a robotic chemistry laboratory as a physical-world testbed to make scientific agency measurable. Its 45 modular workstations exposed as machine-readable skills enabled 4,608 trials. Only 3.3% of trials produced expert-assessed executable workflows under laboratory constraints; even the best system achieved 28.1%. Long-horizon planning remained a challenge: only three executable workflows exceeded 30 operations, although the longest contained 44. Across five rounds, experimental feedback prompted local adjustments but no workflow-level replanning or analytical-method redesign. By making physical executability and evidence-driven replanning measurable, our study provides an evidence-based assessment of deployment readiness and a diagnostic framework to guide closed-loop improvements towards physically grounded autonomous research.

Computer-use agents (CUAs) have advanced along two separate lines: graphical interaction and software development through code and the command line. Real digital work requires both, interleaved rather than stacked end to end. We study hybrid CUAs that autonomously decide when to explore an interface, implement software, and run and visually verify their artifacts. We introduce RecreationWorld, a five-platform framework built around recreation: given a running reference, an agent must discover its behavior and build a faithful implementation with no prescribed workflow. RecreationWorld provides reproducible environments on Ubuntu, macOS, Windows, Android, and Web, plus a unified harness with native GUI control and coding tools. The running reference serves as an oracle for hidden behavioral tests, providing execution-grounded rewards. We scale trajectory generation with high-quality open-source applications. Models trained on these trajectories improve across five out-of-distribution coding and hybrid computer-use benchmarks and more frequently verify their rendered outputs, providing evidence of transfer beyond recreation. For held-out evaluation, we introduce RecreationBench, comprising 250 diverse tasks across domains and platforms. Reference-grounded programmatic and visual assertions cover action-conditioned outcomes at multiple interaction depths; each is validated on the reference and by human reviewers before the suite is frozen for automatic scoring. GPT-6 Astra leads at 58.1% overall, but passes all programmatic tests on just 2.8% of tasks. Agents reproduce static interface structure more reliably than interactions and computed outputs, while generated applications remain smaller and more monolithic than their references. We release the benchmark, environments, and test suites.

Language models are playing an increasingly important role in laboratory science, performing tasks such as experiment planning, execution, and post-hoc analysis. However, precisely measuring their abilities is difficult, as scientific capabilities require a mixture of both problem-solving skills and domain-specific intuition. Existing evaluations rarely measure the capabilities required to make reliable decisions in a physical laboratory and often rely on public data that may have appeared in model training corpora. We introduce onepot-Bench 0, a proprietary benchmark suite for evaluating language models on synthetic chemistry capabilities relevant to wet-lab execution. onepot-Bench 0 comprises three complementary evaluations: ChemAbacus measures tool-free cheminformatics literacy and numerical reasoning; SynthRefusal characterizes safety and refusal behavior across a variety of benign, controlled, and designer-drug targets; and SynthBench evaluates reaction-outcome prediction and catalyst selection using private experimental data generated in our laboratory. Together, these evaluations probe basic competency, reliability, and deeper knowledge, all skills which are required for reliable performance in the lab.