cs.AIAug 19, 2026

Self-prompting and cross-model consensus enable reproducible data extraction from scientific literature with large language models

Authors: Valentin Romanov, Monique Bax, Steven Niederer

Organizations: National Heart & Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom · Cambridge Stem Cell Institute, JeDrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom · Department of Medicine, University of Cambridge, Cambridge, United Kingdom · Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University, CA, USA

Abstract

Accurately extracting nuanced, contextualized data from research articles is laborious and time intensive. Here, we investigate the performance of frontier, browser-based large language models (LLMs) to extract highly contextualized information. We demonstrate four escalating workflows, 1) given an expert curated prompt and research articles, most frontier LLMs perform well at data extraction, however can struggle with interpreting scientific context and nuance, 2) given simple instructions, LLMs can author their own prompts which were almost as eNective as expert-written prompts, 3) autonomous discovery of research literature was diNicult, agents either missed or hallucinated references, and 4) LLMs can create new datasets from published guidelines that closely match human-expert judges, but still require a human-in-the-loop. Together, these findings define an auditable division of labour in which experts specify the evidence standard, models cross-check repeated extractions and researchers resolve disputed cases, providing a practical route to scaling scientific data curation without relinquishing expert oversight.

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