AI-Assisted Scientific Research

Overview

The field studies how AI can help across the research process, from finding and synthesizing literature to proposing ideas, analyzing data, writing code, and planning experiments. Common approaches include retrieval-augmented language models, knowledge graphs, tool-using multi-agent systems, and domain-specific models for areas such as chemistry, biology, and astronomy. Evaluation ranges from literature and coding benchmarks to reproducibility tests and prospective laboratory or field studies. AI is often useful for structured, tool-mediated tasks, but open-ended discovery, reliable screening, calibrated uncertainty, and faithful experimental validation remain difficult, making provenance and human oversight central.

Latest papers

CardsList

253 papers25 papers in the last four weeks, down 7% on the four weeks before. 0.1% of all new papers.

  1. Why and How to Do Science When AI Is Better at It: A Framework Grounded in Human Understanding and Direction

    Oct 26, 2026Hoda Heidari, Aydin MohseniAI-Assisted Scientific ResearchHuman Oversight of AI

  2. BenchBench-Cloning: Evaluating Molecular Cloning Design and Protocol Development

    Oct 23, 2026Aditya Sivakumar, Peter Ciaccia, Hassaan Qadir +2AI-Assisted Scientific ResearchLLM Evaluation

  3. Accelerated Drift of Scientific Prose in the LLM Era: Evidence from an Interrupted Time-Series Analysis

    Oct 19, 2026Hanna Hubarava, Benjamin V. IneichenScientific CommunicationAI-Assisted Scientific Research

  4. AI-Driven Reproducibility and Analytical Robustness in Scientific Discovery

    Oct 16, 2026Shicheng Liu, Krista Opsahl-Ong, Andrew Drozdov +6AI-Assisted Scientific ResearchScientific Reproducibility

  5. ReviewPilot: A Multi-Agent System for Screening and Data Extraction in Systematic Reviews

    Oct 15, 2026Zhaoqian Xue, Shaoze Zhou, Xuexin Li +10Systematic Review AutomationAI-Assisted Scientific Research

  6. Learning Individual Scientific Taste with Privileged Hindsight Distillation

    Oct 14, 2026Hanwei Fan, Yanqiao Wang, Yiqi Zhu +3AI-Assisted Scientific ResearchLearning Using Privileged Information

  7. Synthetic reaction data from transformation rules for graph-to-sequence pretraining in biodegradation pathway prediction

    Oct 14, 2026Irsyaad Rijwan, Liam Brydon, Aidan Jared +1Chemical Reaction PredictionSynthetic Data Pretraining

  8. Into the Unknown: Benchmarking AI agents on open scientific research problems

    Oct 13, 2026Seungone Kim, Jiayi Geng, Young-Jun Lee +25Scientific Agent BenchmarksAI-Assisted Scientific Research

  9. PRAISE: A Reproducible Workflow for Non-Programmer Scientists to Implement Published AI Models

    Oct 12, 2026Max Achterweust, Stefan Groot Nibbelink, Vincent J. de Beer +7ML ReproducibilityScientific Workflow Automation

  10. How Is Automated Research Evaluated? A Survey of Benchmarks and Evaluation Practices

    Oct 8, 2026Liulei Zhang, Dejing Zhou, Chuyue Huang +5AI-Assisted Scientific ResearchBenchmark Design

  11. Incremental Open-Ended Deep Research with Structured Harness

    Oct 8, 2026Meilin Chen, Hongyuan BaoDeep Research AgentsAI-Assisted Scientific Research

  12. When Scientific Cognition Is No Longer Scarce

    Oct 7, 2026Nathan DeBardelebenAI-Assisted Scientific ResearchAI Governance

  13. Progress and Prospect of AI in ARPES Workflow

    Oct 7, 2026Sandy Adhitia Ekahana, Aalok Tiwari, Pratik Saud +4AI-Assisted Scientific ResearchScientific Workflow Automation

  14. When Algorithmic Exploration Becomes Cheap: A Case Study of Agentic Research in EDA

    Oct 7, 2026Keren Zhu, Yu Deng, Xiaoyu Hao +6AI-Assisted Scientific ResearchAutonomous Research Agents

  15. Neural Petri flows for chemical reactions

    Oct 6, 2026Jose Eduardo Escrig Molina, Daniel ProbstAI-Assisted Scientific ResearchChemical Reaction Prediction

  16. Evaluating human-AI workflows for field research in viticulture

    Oct 6, 2026Niko Carvajal Janke, Daoyuan Jin, Shivranjani Baruah +4AI-Assisted Scientific ResearchHuman-in-the-Loop Evaluation

  17. Learning Scientific Exploration from Human Research Decision Trajectories

    Oct 5, 2026Xuchen Gong, Shane Gu, Haokun Liu +3AI-Assisted Scientific Research

  18. FREA: A Multi-Source Expert Benchmark for Reaction Feasibility Verification

    Oct 5, 2026Botao Yu, Bo Zhou, Daniel Adu-Ampratwum +7LLM EvaluationAI-Assisted Scientific Research

  19. ROAR: Unifying Runs across Heterogeneous AI-Driven Research Systems

    Oct 2, 2026Leo Y. Lin, Vishakha Ramani, Z. Berkay Celik +2AI-Assisted Scientific ResearchAutonomous Research Agents

  20. Asterism: Exploring and Synthesizing Scattered Observations into Literature-Grounded Hypotheses and Theories

    Oct 2, 2026Joseph Chee Chang, Michael D'Arcy, Amy X. Zhang +15Scientific Hypothesis GenerationAI-Assisted Scientific Research

  21. Gestalt: a meta-foundation model for astronomy

    Sep 29, 2026Michael J. Smith, Shashwat SouravEnsemble LearningAI-Assisted Scientific Research

  22. RINI: Seeing the Prior Is Not Enough

    Sep 27, 2026Hongyi Du, Tianyi Zhang, Heng Wang +7Novelty SearchAI-Assisted Scientific Research

  23. LabFactory: Building and Evaluating Executable AI Labs

    Sep 23, 2026Jinge Wu, Hongjian Zhou, Mingde Zeng +4AI-Assisted Scientific ResearchAI Agent Evaluation

  24. ChatT2: An Adaptive Framework for Developing a Large Language Model-Based Agent for Natural Product Domain Research

    Sep 22, 2026Yihan Wang, Qiandi Gao, Yihui Zhuang +4Multi-Agent LLM SystemsAI-Assisted Scientific Research

  25. Jev for Scientific Decisions: Evaluating Semantic Choices and Their Consequences

    Sep 21, 2026Boyuan Deng, Shuyi Fan, Hongyang Zhang +1AI-Assisted Scientific ResearchLLM Decision-Making