cs.CVAug 31, 2026

Robust retinal biometrics for patient identity verification and retrieval across age and imaging devices

Authors: Jose D. Vargas-Quiros, Dennis Bontempi, Jeroen Vermeulen, Bart Liefers, Sven Bergmann, Caroline C. W. Klaver

Organizations: Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, the Netherlands · Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands · Dept. of Computational Biology, University of Lausanne, Lausanne, Switzerland · Swiss Institute of Bioinformatics, Lausanne, Switzerland · Dept. of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa · Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands · Institute of Molecular and Clinical Ophthalmology, University of Basel, Switzerland

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Abstract

Patient identity errors can compromise longitudinal medical records, research databases, and downstream clinical decisions. We present a retinal biometric system for verifying claimed identities and retrieving the correct identity from color fundus images. We trained a 512-dimensional metric-learning encoder combining a ConvNeXtV2 backbone with ArcFace and triplet losses on 227,004 images from 21,851 patient-eye identities in the Rotterdam Study, spanning multiple imaging devices and up to 32.6 years of follow-up. The system was evaluated on held-out Rotterdam Study data and externally on the UK Biobank and Age-Related Eye Disease Study (AREDS). Before evaluation, we used the model to screen for identity inconsistencies and manually adjudicated flagged images, identifying incorrect assignments in 0.588% of Rotterdam Study images, 0.259% of UK Biobank images, and 0.164% of AREDS images. In retrospective-only verification after removing near-duplicate images, the system achieved AUROCs of 0.9998, 0.9997, and 0.9998 in the Rotterdam Study, UK Biobank, and AREDS, respectively. For identity retrieval using only previously acquired images, Recall@1 was 99.7%, 97.2%, and 97.6%, respectively, from galleries averaging 4436-8510 identities; the correct identity appeared among the top five results in at least 98.6% of cases. Performance remained robust across imaging devices and long follow-up intervals, while lower image quality and inconsistent retinal fields accounted for most failures. These findings establish retinal anatomy as a durable biometric signal, useful for safeguarding the integrity of longitudinal imaging records.

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