Automated brain tumor segmentation supports diagnosis, treatment planning, and monitoring of disease progression, but building models that generalize across heterogeneous tumors and limited annotated data remains difficult. We present VGG16-MCA UNet, a hybrid architecture pairing an ImageNet-pretrained VGG16 encoder with a decoder in which a Multi-Channel Attention (MCA) module recalibrates features after each skip-connection fusion, trained with the Focal Tversky loss to counter severe foreground-background imbalance. We evaluate the model as a 2D, FLAIR-only, whole-tumor segmenter on tumor-positive slices from two public datasets: the BraTS 2020 benchmark and the LGG MRI Segmentation dataset. Using 5-fold cross-validation and a single network formed by averaging the weights of the five fold models, the method attains an aggregate pixel-level Dice (F1) of 95.10% on our held-out BraTS 2020 split and 88.32% on LGG. These scores are computed over all test pixels pooled into a single confusion matrix rather than averaged per case, and are therefore not directly comparable to the per-case mean Dice used in the BraTS challenge protocol. All partitions were drawn over individual slices rather than over patients, so every patient contributes slices to both training and test; the figures above therefore measure interpolation within known patients and should be read as an upper bound rather than as generalization to new ones. The model segments a 256x256 slice in 66.32 ms on a single 6 GB NVIDIA RTX 2060, approximately 8 ms more than an equivalent VGG16-UNet without MCA. We release the split records and report the protocol in full, with the aim of providing a precisely specified and reproducible 2D FLAIR baseline.
Brain cancer's severity necessitates precise brain tumor segmentation, which is crucial for effective brain tumor diagnosis. Manual identification, burdened by high costs, labor, and error risks, highlights the need for automated methods. In this study, we introduce the Global Context-aware Squeeze and Excite Residual UNet (GCSER-UNet), which facilitates a fusion of spatial and channel-wise attention and thus enhances the model's capacity to capture intricate spatial dependencies and contextual information. GCSER-UNet efficiently extracts tumor segments from multimodal MRI slices, delivering exceptional performance. Evaluations on benchmark databases exhibit its superiority, achieving a notable 94 percent dice score on the TCGA LGG dataset, surpassing the state-of-the-art dice score of 91.8 percent. In the BraTS 2020 dataset, the proposed GCSER-UNet ensemble approach yielded dice scores of 95 percent, 92 percent, and 90 percent for the tumor regions - Whole Tumor (W), Tumor Core (T), and Enhancing Tumor (E), respectively. The current state-of-the-art dice scores were 94 percent, 93 percent, and 88 percent. These compelling outcomes highlight the efficacy of GCSER-UNet in precise brain tumor segmentation and thus can aid neurologists in effective brain cancer management and treatment planning.
Sourjya Mukherjee, Ananya Bhattacharjee, R. Murugan
Accurate segmentation of brain tumour sub-regions from multi-parametric MRI is critical for treatment planning yet remains challenging due to morphological variability, class imbalance, and overlapping appearances of tumour regions across imaging sequences. We propose SegGuidedNet, a three-dimensional residual encoder--decoder network introducing a novel SegAttentionGate module that explicitly supervises the decoder to produce spatially discriminative attention maps for each tumour sub-region necrotic core, peritumoral oedema, and enhancing tumour via a lightweight auxiliary loss, adding less than 0.2% parameter overhead. This sub-region supervision maintains decoder discriminability between visually ambiguous classes while providing free-of-cost spatial interpretability at inference without any post-hoc explanation method. Evaluated independently on BraTS2021 and BraTS2023 GLI across 251 held-out subjects each, SegGuidedNet achieves mean Dice of 0.905 (ET= 0.873, TC=0.906, WT=0.935) and 0.897 (ET=0.859, TC=0.902, WT=0.931) respectively, surpassing ensemble-based nnU-Net and HNF-Netv2 as a single model and approaching Swin UNETR a 10-model ensemble within 2--4 Dice points at a fraction of the inference cost. The consistency of results across two benchmark editions further confirms the generalisability of the proposed approach, offering competitive accuracy with built-in interpretability in a lightweight, clinically practical framework.
Hasaan Maqsood, Saif Ur Rehman Khan, Sebastian Vollmer +2
Multimodal MRI offers complementary information for brain tumor segmentation, but clinical scans often lack one or more modalities, which degrades segmentation performance. In this paper, we propose UniME (Uni-Encoder Meets Multi-Encoders), a two-stage heterogeneous method for brain tumor segmentation with missing modalities that reconciles the trade-offs among fine-grained structure capture, cross-modal complementarity modeling, and exploitation of available modalities. The idea is to decouple representation learning from segmentation via a two-stage heterogeneous architecture. Stage 1 pretrains a single ViT Uni-Encoder with masked image modeling to establish a unified representation robust to missing modalities. Stage 2 adds modality-specific CNN Multi-Encoders to extract high-resolution, multi-scale, fine-grained features. We fuse these features with the global representation to produce precise segmentations. Experiments on BraTS 2023 and BraTS 2024 show that UniME outperforms previous methods under incomplete multi-modal scenarios. The code is available at https://github.com/Hooorace-S/UniME