Evaluating Transformation Models for pCLE Mosaic Registration

Lissajous confocal laser endomicroscopy (CLE) is a promising solution for high speed in vivo optical biopsy for handheld scenarios. However, Lissajous scanning traces a resonant trajectory and samples only the visited pixels per frame; at high frame rates, many pixels remain unvisited, creating structured holes. In this work, we introduce the first benchmark for high-rate Lissajous CLE, consisting of low-quality video clips paired with high-quality reference images. The reference images are wide-FOV mosaics obtained by stitching stabilized, slow-scan frames of the same tissue, enabling temporally aligned supervision. Using this dataset, we propose MIRA, a lightweight recurrent framework for Lissajous CLE restoration that iteratively aggregates temporal context through feature reuse and displacement alignment. Our experiments demonstrate that MIRA outperforms both lightweight and high-complexity baselines in restoration quality while maintaining a favorable computational efficiency suitable for clinical deployment.

Point-cloud (PC) registration is fundamental to three-dimensional (3D) perception in robotic systems. However, classic registration algorithms falter when aligning a source PC containing limited, incomplete, or ambiguous geometric cues against a reference. This challenge of registering a small, partial PC to a significantly larger global reference is pervasive in real-world deployment yet remains insufficiently addressed by existing learning-based approaches, which typically assume comparable scales and significant overlap. To bridge this gap, we propose the Region-based Small-to-Large Point-cloud Registra- tion framework (R-SLPR), a novel three-stage architecture that fundamentally reformulates the scale-mismatched registration problem into a sequence of region proposal, regional matching, and iterative refinement. Unlike conventional methods that fail to localize specific regions, R-SLPR explicitly identifies candidate regions prior to estimating rigid transformations, ensuring robust alignment even under severe scale mismatch. The framework introduces a Fibonacci Grid Segmentation method coupled with a contrastive learning objective to effectively generate and match local geometric patches. Building on this, a novel Cascade Anchor Selection and Refinement algorithm iteratively aligns the source with the target region to maximize precision. Extensive evaluation on ModelNet40 demonstrates that R-SLPR establishes a new state-of-the-art accuracy standard, outperforming prior approaches and significantly reducing position and rotation Mean Absolute Error (MAE) to 0.009 and 1.104, respectively.

3D point cloud registration in laparoscopic surgery estimates the transformation between an intraoperative organ reconstructed from video and its preoperative mesh. Because ground-truth transformations are unavailable for real data, supervised networks are trained on synthetic organ pairs. At test time, real reconstructions differ from synthetic data and are noisy, sparse, and occluded, which degrades correspondence estimation. Test-time adaptation (TTA) can reduce this domain shift, but existing methods mainly rely on logits, entropy, class prototypes, or cache memories unavailable in registration. Registration also involves paired inputs with an asymmetric shift that primarily affects the intraoperative cloud. We analyse and modify state-of-the-art TTA methods from three families to 3D registration: model, normalization, and input adaptation. We analyze four representative approaches based on auxiliary-task model updates, backpropagation-free token purging, feature alignment, and layer-normalization calibration. We modify them to handle asymmetric shifts between preoperative and intraoperative point clouds and replace classification-based entropy objectives. Using a correspondence-based model trained on clean synthetic source data, we evaluate adaptation to corrupted synthetic and real target data on P2P and P2ILReg. For synthetic targets, we apply eight corruptions, including uniform noise and global density reduction, at five severity levels. All methods improve registration on P2P, whereas normalization adaptation degrades performance on P2ILReg. Considering the computational overhead of backpropagation-based adaptation, input adaptation is the most promising option for laparoscopic surgery, providing low inference latency and consistent error reductions across datasets. Code: https://github.com/ninaa-git/survey_pc_registration_tta