Organizations: Department of Computer Science, Indian Institute of Science Education and Research Berhampur, India · Department of Mathematics, Indian Institute of Technology Jodhpur, India · School of Artificial Intelligence and Data Science, Indian Institute of Technology Jodhpur, India
Skin cancer is a major global health concern, and early detection and accurate lesion delineation are important for effective diagnosis and treatment planning. Automated skin lesion analysis can assist dermatologists, with lesion segmentation serving as a fundamental step in computer-aided diagnostic systems. Conventional deep learning-based segmentation models typically rely on centralized training, where images and their corresponding segmentation masks are collected on a central server. Such data aggregation raises privacy concerns in medical applications and requires substantial centralized computational resources. To address these limitations, we investigate the feasibility of federated learning for privacy-preserving skin lesion segmentation. The training and validation sets of the ISIC 2018 Skin Lesion Segmentation Challenge dataset are used to simulate a distributed learning environment and develop a federated segmentation model. The resulting model is evaluated on the ISIC 2018 test set and the PH2 dataset to assess its performance and generalizability. Experimental results demonstrate that the federated model achieves performance comparable to centralized training while consistently improving upon the locally trained models. These findings demonstrate the potential of federated learning for collaborative skin lesion segmentation without requiring centralized aggregation of medical images.
Figures & tables
Figure 1: The flow diagram of training segmentation network with federated learning. Orgi refers to ith client; W_Orgi refers to local weight update in ith client during a communication round; W_Fed refers to global model after local model aggregation.
Network
Model
Dice
IoU
Accuracy
Precision
Recall
F1
UNet
local-1
0.882
0.789
0.937
0.934
0.835
0.882
local-2
0.883
0.791
0.936
0.92
0.849
0.883
local-3
0.880
0.786
0.935
0.912
0.850
0.880
local-4
0.877
0.782
0.933
0.909
0.848
0.877
local-5
0.881
0.787
0.935
0.911
0.853
0.881
global-L
0.919
0.850
0.950
0.908
0.930
0.919
Table 1: Performance in the test set of ISIC 2018 skin lesion segmentation challenge dataset
Network
Model
Dice
IoU
Accuracy
Precision
Recall
F1
UNet
local-1
0.854
0.745
0.911
0.905
0.808
0.854
local-2
0.851
0.741
0.907
0.88
0.824
0.851
local-3
0.858
0.751
0.911
0.887
0.831
0.858
local-4
0.847
0.735
0.903
0.861
0.833
0.847
local-5
0.846
0.733
0.905
0.888
0.808
0.846
global-L
0.869
0.769
0.915
0.862
0.877
0.869
Table 2: Results of various models trained with ISIC 2018 and tested with the PH2 dataset
Figure 2: Pictorial representation of segmentation results generated by the global-L and global-FL models for both TransUNet and UNet tested with ISIC 2018 dataset
Figure 3: Results of the global-FL TransUNet model trained and tested on ISIC 2018 dataset considering Dice, Focal, BCE, Dice+Focal, Dice+BCE, and Focal+BCE losses
Figure 4: Performances yield by the global-FL TransUNet model trained and tested on the ISIC 2018 dataset, when the #epochs in each iteration during federated learning is varied from 1 (epoch_1) to 5 (epoch_5) and 10 (epoch_10).
Federated Learning (FL) enables collaborative training of machine learning models across multiple institutions without sharing sensitive data, making it particularly suitable for medical imaging applications. However, heterogeneous data distributions across institutions and potential information leakage through model updates remain important challenges. In this work, we propose DP-SimAgg, a privacy-preserving federated learning framework that integrates similarity-weighted aggregation with a server-side differential privacy mechanism. The proposed method applies L2 clipping to bound collaborator updates, computes similarity-based aggregation weights to mitigate the effects of non-IID data distributions, and injects calibrated Gaussian noise at the central server, providing per-round privacy guarantees under the assumed sensitivity bound. The framework is implemented using Intel's OpenFL platform and evaluated on the FeTS 2022 dataset consisting of 1251 multi-modal MRI scans for brain tumor segmentation. Experimental results demonstrate that DP-SimAgg maintains competitive segmentation performance while providing privacy protection. Under a strict per-round privacy budget (epsilon = 1, cumulative epsilon_total = 20 over 20 rounds), the method achieves Dice scores of 0.6357, 0.5305, and 0.5274 for the enhancing tumor (ET), tumor core (TC), and whole tumor (WT) regions, respectively. With a more relaxed per-round budget (epsilon = 10, cumulative epsilon_total = 200), performance approaches that of the non-private baseline while incorporating a central Gaussian mechanism with per-round (epsilon, delta)-DP accounting under the assumed sensitivity bound. These results highlight the potential of DP-SimAgg for enabling privacy-preserving collaborative learning in medical imaging applications.
Muhammad Irfan Khan, Eero Lehtonen, Joni Obradovic +4
Turku University of Applied Sciences, Turku 20520, Finland
Background and Objective: Automatic polyp segmentation supports computer-aided diagnosis and early colorectal cancer detec- tion. Centralized deep learning requires hospitals to share sensitive medical data, while federated learning preserves privacy but introduces high communication costs through repeated transmission of full-precision model parameters. We propose QFedPolyp, a communication- and inference-efficient federated learning framework for collaborative polyp segmentation. Methods: QFedPolyp combines quantization-aware training with low-precision model communication. Each hospital locally trains a lightweight U-Net on private data while simulating quantization during training. Clients transmit quantized model parameters to a central server, where they are reconstructed and aggregated using Federated Averaging. Evaluation is performed on Kvasir-SEG, CVC-ClinicVideoDB, PolypGen, and BKAI-IGH NeoPolyp. Results: Full-precision federated training achieves Dice scores of 0.910 on Kvasir-SEG and 0.930 on CVC-ClinicVideoDB. Uni- form 8-bit communication reduces transmission cost by approximately 4 times while preserving competitive segmentation accuracy. Quantized models also achieve up to 1.5 times faster inference than full-precision models. Conclusions: QFedPolyp enables privacy-preserving collaborative polyp segmentation with reduced communication overhead and faster inference. The resulting lightweight models are suitable for real-time clinical deployment.
Madan Baduwal, Priyanka Paudel
Department of Computer Science and Engineering, Mississippi State University Mississippi State, MS, USA
Federated Learning enables decentralized training by aggregating model updates across clients without sharing raw data, while Split Federated Learning further partitions the model between clients and a server to reduce computation and communication at the client side. However, decentralized medical institutions rarely operate on a single shared task, making standard Federated and SplitFed collaborations poorly aligned with real clinical workflows. Multi-task FL extends these frameworks by allowing clients to handle different tasks, but often introduces instability and privacy vulnerabilities. This study proposes \textbf{MuCALD-SplitFed}, a multi-task SplitFed framework that integrates causal representation learning and latent diffusion. Experiments show MuCALD-SplitFed consistently improves segmentation, while baseline SplitFed fails to converge. The proposed approach further reduces information leakage at split points, mitigating reconstruction-based and membership inference attacks. Additionally, MuCALD SplitFed outperforms state-of-the-art personalized FL and multi-task FL approaches. The code repository is: https://github.com/ChamaniS/MuCALD_SplitFed.
Chamani Shiranthika, Hadi Hadizadeh, Parvaneh Saeedi
School of Engineering Science, Simon Fraser University, Burnaby, BC, Canada