U-Net inference for brain-tumor segmentation requires billions of multiply-accumulate operations, motivating hardware that can reduce computation dynamically rather than relying only on fixed precision or static model compression. Most-significant-digit-first (MSDF) arithmetic exposes the leading digits of a result during computation, enabling output-dependent decisions before the full value is generated. This paper presents an MSDF accelerator for quantized U-Net segmentation with a two-stage grouped processing element supporting signed INT8 operands and in-stream bias accumulation. Four runtime mechanisms operate directly on the output digit stream: exact early negative detection (END) in ReLU layers, exact sign-only decision making in the segmentation head, calibrated low-order-digit skipping, and calibrated pruning. The two approximate mechanisms are selected offline under an accuracy constraint, while execution requires only lightweight control and does not modify the stored weights. On a residual U-Net trained with nnU-Net for BraTS, the proposed mechanisms reduce digit cycles by 38.38% while achieving a mean Dice score of 80.58% on 73 held-out cases, compared with 81.20% for the floating-point model; the exact mechanisms alone reduce cycles by 18.79% without altering the quantized output. Synthesized in 45nm, the processing element operates at 500MHz, occupies 0.858mm2, and consumes 0.726mJ per 192×192 patch under switching-activity-annotated power analysis. A projected eight-output accelerator with shared activation delivery achieves 16.6ms latency and 1.67mJ per patch.
This paper presents an energy-efficient hardware acceleration of the convolutional layers in the U-Net architecture for image segmentation, implemented on FPGA. While digit-serial arithmetic, particularly most-significant-digit-first (MSDF) techniques, offers a compact hardware footprint, it suffers from initial latency before producing the first output digit. This delay accumulates in cascaded operations like multiplication followed by addition, where each unit introduces its own startup overhead. To overcome this, we propose a merged multiply-add (MMA) architecture that fuses these operations into a unified pipeline. Instead of incurring separate delays, the MMA introduces a single streamlined latency per iteration, shorter than the combined latency of conventional cascaded units, resulting in enhanced throughput and efficiency. The MMA units are designed to process spatial input depths in parallel, achieving significantly higher performance than both standalone MSDF-based and conventional designs. We evaluate the proposed design using U-Net as a target application. Despite operating at a lower frequency than a CPU, the FPGA-based accelerator achieves up to an order of magnitude higher energy efficiency, delivering up to 15.14 GOPS/W compared to 1.93 GOPS/W for CPU-based inference. The design also shows approximately 9× reduction in energy consumption compared to MSDF-based FPGA implementations. These results highlight the efficacy of the merged arithmetic approach for resource-constrained, latency-sensitive edge applications in medical imaging and computer vision.
Muhammad Usman, Yousef Sadegheih, Dorit Merhof
Faculty of Informatics and Data Science, University of Regensburg, 93053 Regensburg, Germany
Automatic brain tumor segmentation from multi-modal MRI remains challenging because volumetric models often incur substantial computational cost. This paper presents DALight-3D, a compact 3D U-Net variant that combines depthwise separable 3D convolutions, identifier-conditioned normalization, cross-slice attention, and adaptive skip fusion. The method is evaluated on the Medical Segmentation Decathlon Task01 BrainTumour benchmark under matched optimization settings against standard 3D U-Net, Attention U-Net, Residual 3D U-Net, and V-Net baselines. In the reported 50-epoch comparison, DALight-3D achieves a mean Dice of 0.727 with 2.22M parameters, compared with 0.710 Dice and 3.20M parameters for Residual 3D U-Net. Component-wise ablations show consistent performance degradation when SepConv, identifier-conditioned normalization, CSA, or SSFB is removed. These results indicate that DALight-3D offers a favorable accuracy-efficiency trade-off within the present benchmark setting.
Nand Kumar Mishra, Dhruv Mishra, Dr Manu Pratap Singh
Department of Computer Science, Dr. Bhimrao Ambedkar University, Agra, India. · Department of Computer Science and Engineering, Shiv Nadar University, Greater Noida, India.
Accurate 3D brain tumour segmentation from multi-modal Magnetic Resonance Imaging (MRI) is essential for clinical diagnosis and treatment planning. Existing brain tumour segmentation methods often suffer from heavy computational demands, while current lightweight architectures frequently lack the capacity to maintain segmentation fidelity in complex tumour regions. To address these issues, we propose a novel ultra-lightweight framework (Uni-Light) that achieves high-fidelity segmentation with substantially reduced computational overhead. It combines multi-scale convolutions with an uncertainty-aware knowledge distillation scheme that directs the student model toward hard-to-classify regions, complemented by a Signed Distance Field boundary loss for geometric constraints. Experimental results on BraTS2023-GLI and MSD-BTS datasets demonstrate that Uni-Light reduces parameters by 97.56%, floating-point operations (FLOPs) by 73.03%, and inference memory footprint by 81.58%, while surpassing the state-of-the-art model by an average of 1.47% in Dice score, offering a highly competitive trade-off between segmentation accuracy and computational efficiency in resource-constrained clinical settings. This work also advances data engineering for medical imaging by demonstrating that teacher model uncertainty can be exploited as a data-driven supervisory signal, re-prioritising the training data distribution without requiring additional annotation.
Libing Kuang, Soren Salehi, Ziling Wu +2
School of Computer Science, University of Nottingham, Nottingham, UK · Electrical Engineering Department, Sharif University of Technology, Tehran, Iran · University of Pittsburgh, Pittsburgh, PA, USA