Attention Residual U-Net for Enhanced Cross-Dataset Polyp Localization in Endoscopy

Early detection of colorectal polyps is essential for preventing colorectal cancer, making accurate polyp segmentation a key component in computer-aided diagnosis systems. However, existing endoscopic segmentation methods often exhibit limited representational capacity and insufficient integration of global and local contextual information. To address these limitations, we propose Polyp-VSSD, a novel local-global joint decoding framework built upon a pre-trained Transformer backbone for high-precision polyp segmentation. Polyp-VSSD leverages the strong feature expressiveness of large-scale visual pre-training and unifies global semantic modeling with local fine-grained reconstruction to enhance segmentation fidelity. Extensive experiments on multiple public endoscopic datasets demonstrate that our approach significantly outperforms state-of-the-art methods in both Dice and IoU. On the EndoScene dataset, Polyp-VSSD achieves mIoU and mDice scores of 0.903 and 0.946, respectively, highlighting its robustness and strong generalization capability. This work presents an effective and scalable solution for intelligent endoscopic image analysis.

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, predominantly arising from precancerous polyps. Accurate detection, segmentation, and endoscopic and histological classification of colorectal polyps are crucial for timely clinical intervention. In this study, we present PolypVision, a three-stage hierarchical deep learning framework that sequentially performs: (Stage 1) binary classification of polyps as adenomatous or hyperplastic, with simultaneous Paris and JNet classification, using EfficientNetV2-M with Focal Loss; (Stage 2) polyp segmentation with recommended resection method using a UNet++ decoder with the Stage 1 backbone as encoder, optimized with Dice and BCE losses; and (Stage 3) adenoma subtype classification (tubular, tubulovillous, villous) using EfficientNetV2-M with transfer learning from Stage 2. Evaluated on three public datasets -- PolypGen, Kvasir-SEG, and CVC-ClinicDB -- PolypVision achieves an AUC of approximately 0.99 for frame classification and a detection mAP@50 of 94.4% on Kvasir-SEG, outperforming or matching state-of-the-art methods. Gradient-weighted Class Activation Maps (Grad-CAM) confirm that the model attends to clinically relevant lesion features. The framework is device-independent, operating across diverse endoscopic imaging systems without hardware-specific adaptation. These results demonstrate that a hierarchical, transfer-learning-driven pipeline with task-specific loss functions offers a robust, device-independent, and clinically meaningful approach to automated colorectal polyp analysis. PolypVision is freely available as a web application at https://polypvision.com, a DataBioX initiative, with a free usage tier open to all users.

Accurate polyp segmentation in colonoscopy is essential for early colorectal cancer detection, yet real-world clinical environments pose persistent challenges such as motion blur, specular reflections, and illumination instability. Most existing methods are optimized on clean benchmark images and suffer noticeable performance degradation when deployed in authentic surgical scenarios. We propose DepthPolyp, a lightweight and robust segmentation framework based on pseudo-depth-guided multi-task learning and efficient feature modulation. The architecture combines hierarchical Ghost factorization for compact feature generation, Interleaved Shuffle Fusion for low-cost cross-scale interaction, and Dynamic Group Gating for adaptive group-wise feature weighting. Extensive experiments demonstrate that DepthPolyp achieves strong cross-dataset generalization when trained on degraded data and evaluated on both clean and noisy target domains, consistently outperforming lightweight baselines and remaining competitive with substantially larger models. In real surgical video evaluation on PolypGen, DepthPolyp achieves better segmentation performance than models up to $20\times$ larger while preserving real-time inference speed. With only 3.57M parameters and 0.86 GMACs, the proposed method runs at over 180 FPS on mobile devices, making it well suited for real-time deployment in resource-constrained clinical environments. Code and pretrained weights are available at: https://github.com/ReaganWu/DepthPolyp/