Image Restoration

The advent of handheld fundus imaging devices has made ophthalmologic diagnosis and disease screening more accessible, efficient, and cost-effective. However, images captured from these setups often suffer from artifacts such as flash reflections, exposure variations, and motion-induced blur, which degrade image quality and hinder downstream analysis. While generative models have been effective in image restoration, most depend on paired supervision or predefined artifact structures, making them less adaptable to unstructured degradations commonly observed in handheld fundus images. To address this, we propose an unsupervised diffusion autoencoder that integrates a context encoder with the denoising process to learn semantically meaningful representations for artifact restoration. The model is trained only on high-quality table-top fundus images and infers to restore artifact-affected handheld acquisitions. We validate the restorations through quantitative and qualitative evaluations, and have shown that diagnostic accuracy increases to 81.17% on an unseen dataset and multiple artifact conditions

Ultra-high-definition (UHD) image restoration poses unique challenges due to the high spatial resolution, diverse content, and fine-grained structures present in UHD images. To address these issues, we introduce a progressive spectral decomposition for the restoration process, decomposing it into three stages: zero-frequency \textbf{enhancement}, low-frequency \textbf{restoration}, and high-frequency \textbf{refinement}. Based on this formulation, we propose a novel framework, \textbf{ERR}, which integrates three cooperative sub-networks: the zero-frequency enhancer (ZFE), the low-frequency restorer (LFR), and the high-frequency refiner (HFR). The ZFE incorporates global priors to learn holistic mappings, the LFR reconstructs the main content by focusing on coarse-scale information, and the HFR adopts our proposed frequency-windowed Kolmogorov-Arnold Network (FW-KAN) to recover fine textures and intricate details for high-fidelity restoration. To further advance research in UHD image restoration, we also construct a large-scale, high-quality benchmark dataset, \textbf{LSUHDIR}, comprising 82{,}126 UHD images with diverse scenes and rich content. Our proposed methods demonstrate superior performance across a range of UHD image restoration tasks, and extensive ablation studies confirm the contribution and necessity of each module. Project page: https://github.com/NJU-PCALab/ERR.

Adverse lighting conditions, such as cast shadows and irregular illumination, pose significant challenges to computer vision systems by degrading visibility and color fidelity. Consequently, effective shadow removal and ALN are critical for restoring underlying image content, improving perceptual quality, and facilitating robust performance in downstream tasks. However, while achieving state-of-the-art results on specific benchmarks is a primary goal in image restoration challenges, real-world applications often demand robust models capable of handling diverse domains. To address this, we present a comprehensive study on lighting-related image restoration by exploring two contrasting strategies. We leverage a robust framework for ALN, DINOLight, as a specialized baseline to exploit the characteristics of each individual dataset, and extend it to OmniLight, a generalized alternative incorporating our proposed Wavelet Domain Mixture-of-Experts (WD-MoE) that is trained across all provided datasets. Through a comparative analysis of these two methods, we discuss the impact of data distribution on the performance of specialized and unified architectures in lighting-related image restoration. Notably, both approaches secured top-tier rankings across all three lighting-related tracks in the NTIRE 2026 Challenge, demonstrating their outstanding perceptual quality and generalization capabilities. Our codes are available at https://github.com/OBAKSA/Lighting-Restoration.

Adversarial attacks pose a severe threat to the reliability of deep learning models in remote sensing (RS) image classification. Most existing methods rely on direct pixel-wise perturbations, failing to exploit the inherent atmospheric characteristics of RS imagery or survive real-world image degradations. In this paper, we propose FogFool, a physically plausible adversarial framework that generates fog-based perturbations by iteratively optimizing atmospheric patterns based on Perlin noise. By modeling fog formations with natural, irregular structures, FogFool generates adversarial examples that are not only visually consistent with authentic RS scenes but also deceptive. By leveraging the spatial coherence and mid-to-low-frequency nature of atmospheric phenomena, FogFool embeds adversarial information into structural features shared across diverse architectures. Extensive experiments on two benchmark RS datasets demonstrate that FogFool achieves superior performance: not only does it exceed in white-box settings, but also exhibits exceptional black-box transferability (reaching 83.74% TASR) and robustness against common preprocessing-based defenses such as JPEG compression and filtering. Detailed analyses, including confusion matrices and Class Activation Map (CAM) visualizations, reveal that our atmospheric-driven perturbations induce a universal shift in model attention. These results indicate that FogFool represents a practical, stealthy, and highly persistent threat to RS classification systems, providing a robust benchmark for evaluating model reliability in complex environments.

Video face restoration aims to enhance degraded face videos into high-quality results with realistic facial details, stable identity, and temporal coherence. Recent diffusion-based methods have brought strong generative priors to restoration and enabled more realistic detail synthesis. However, existing approaches for face videos still rely heavily on generic diffusion priors and multi-step sampling, which limit both facial adaptation and inference efficiency. These limitations motivate the use of one-step diffusion for video face restoration, yet achieving faithful facial recovery alongside temporally stable outputs remains challenging. In this paper, we propose, DVFace, a one-step diffusion framework for real-world video face restoration. Specifically, we introduce a spatio-temporal dual-codebook design to extract complementary spatial and temporal facial priors from degraded videos. We further propose an asymmetric spatio-temporal fusion module to inject these priors into the diffusion backbone according to their distinct roles. Evaluation on various benchmarks shows that DVFace delivers superior restoration quality, temporal consistency, and identity preservation compared to recent methods. Code: https://github.com/zhengchen1999/DVFace.

Vision-language agents that orchestrate specialized tools for image restoration (IR) have emerged as a promising method, yet most existing frameworks operate in a training-free manner. They rely on heuristic task scheduling and exhaustive tool traversal, resulting in sub-optimal restoration paths and prohibitive computational cost. We argue that the core bottleneck lies in the absence of a learned policy to make decision, as a vision-language model cannot efficiently handle degradation-aware task ordering and tool composition. To this end, we propose TIR-Agent, a trainable image restoration agent that performs a direct tool-calling policy through a two-stage training pipeline of supervised fine-tuning (SFT) followed by reinforcement learning (RL). Two key designs underpin effective RL training: (i) a random perturbation strategy applied to the SFT data, which broadens the policy's exploration over task schedules and tool compositions, and (ii) a multi-dimensional adaptive reward mechanism that dynamically re-weights heterogeneous image quality metrics to mitigate reward hacking. To support high-throughput, asynchronous GPU-based tool invocation during training, we further develop a globally shared model-call pool. Experiments on both in-domain and out-of-domain degradations show that TIR-Agent outperforms 12 baselines, including 6 all-in-one models, 3 training-free agents, and 3 proprietary models, and achieves over 2.5$\times$ inference speedup by eliminating redundant tool executions.

Face images captured in real-world low light suffer multiple degradations-low illumination, blur, noise, and low visibility, etc. Existing cascaded solutions often suffer from severe error accumulation, while generic joint models lack explicit facial priors and struggle to resolve clear face structures. In this paper, we propose PASDiff, a Physics-Aware Semantic Diffusion with a training-free manner. To achieve a plausible illumination and color distribution, we leverage inverse intensity weighting and Retinex theory to introduce photometric constraints, thereby reliably recovering visibility and natural chromaticity. To faithfully reconstruct facial details, our Style-Agnostic Structural Injection (SASI) extracts structures from an off-the-shelf facial prior while filtering out its intrinsic photometric biases, seamlessly harmonizing identity features with physical constraints. Furthermore, we construct WildDark-Face, a real-world benchmark of 700 low-light facial images with complex degradations. Extensive experiments demonstrate that PASDiff significantly outperforms existing methods, achieving a superior balance among natural illumination, color recovery, and identity consistency. Code and dataset will be available at https://github.com/IVIPLab/PASDiff.

In this work, we propose Image-to-Image Rectified Flow Reformulation (I2I-RFR), a practical plug-in reformulation that recasts standard I2I regression networks as continuous-time transport models. While pixel-wise I2I regression is simple, stable, and easy to adapt across tasks, it often over-smooths ill-posed and multimodal targets, whereas generative alternatives often require additional components, task-specific tuning, and more complex training and inference pipelines. Our method augments the backbone input by channel-wise concatenation with a noise-corrupted version of the ground-truth target and optimizes a simple t-reweighted pixel loss. This objective admits a rectified-flow interpretation via an induced velocity field, enabling ODE-based progressive refinement at inference time while largely preserving the standard supervised training pipeline. In most cases, adopting I2I-RFR requires only expanding the input channels, and inference can be performed with a few explicit solver steps (e.g., 3 steps) without distillation. Extensive experiments across multiple image-to-image translation and video restoration tasks show that I2I-RFR generally improves performance across a wide range of tasks and backbones, with particularly clear gains in perceptual quality and detail preservation. Overall, I2I-RFR provides a lightweight way to incorporate continuous-time refinement into conventional I2I models without requiring a heavy generative pipeline.

Single image reflection removal (SIRR) is challenging in real scenes, where reflection strength varies spatially and reflection patterns are tightly entangled with transmission structures. This paper presents a diffusion model with prior modulation framework (FUMO) that introduces explicit priors for spatially adaptive conditioning and structurally faithful restoration. Two priors are extracted directly from the mixed image, an intensity prior that estimates spatial reflection severity and a high-frequency prior that captures detail-sensitive responses via multi-scale residual aggregation. We propose a coarse-to-fine training paradigm. In the first stage, these cues are combined to gate the conditional residual injections, focusing the conditioning on regions that are both reflection-dominant and structure-sensitive. In the second stage, a fine-grained refinement network corrects local misalignment and sharpens fine details in the image space. Experiments conducted on both standard benchmarks and challenging images in the wild demonstrate competitive quantitative results and consistently improved perceptual quality. The code is released at https://github.com/Lucious-Desmon/FUMO.

Wildlife re-identification aims to recognise individual animals by matching query images to a database of previously identified individuals, based on their fine-scale unique morphological characteristics. Current state-of-the-art models for multispecies re- identification are based on deep metric learning representing individual identities by fea- ture vectors in an embedding space, the similarity of which forms the basis for a fast automated identity retrieval. Yet very often, the discriminative information of individual wild animals gets significantly reduced due to the presence of several degradation factors in images, leading to reduced retrieval performance and limiting the downstream eco- logical studies. Here, starting by showing that the extent of this performance reduction greatly varies depending on the animal species (18 wild animal datasets), we introduce an augmented training framework for deep feature extractors, where we apply artificial but diverse degradations in images in the training set. We show that applying this augmented training only to a subset of individuals, leads to an overall increased re-identification performance, under the same type of degradations, even for individuals not seen during training. The introduction of diverse degradations during training leads to a gain of up to 8.5% Rank-1 accuracy to a dataset of real-world degraded animal images, selected using human re-ID expert annotations provided here for the first time. Our work is the first to systematically study image degradation in wildlife re-identification, while introducing all the necessary benchmarks, publicly available code and data, enabling further research on this topic.

Training instability remains a critical challenge in large language model (LLM) pretraining, often manifesting as sudden gradient explosions that waste significant computational resources. We study training failures in a 5M-parameter NanoGPT model scaled via $μ$P, identifying two key phenomena preceding collapse: (1) rapid decline in weight matrix stable rank (ratio of squared Frobenius norm to squared spectral norm), and (2) increasing alignment between adjacent layer Jacobians. We prove theoretically that these two conditions jointly cause exponential gradient norm growth with network depth. To break this instability mechanism, we propose MSign, a new optimizer that periodically applies matrix sign operations to restore stable rank. Experiments on models from 5M to 3B parameters demonstrate that MSign effectively prevents training failures with a computational overhead of less than 7.0%.

Low-resolution remote sensing small object detection is limited by both missing visual details and the ambiguity of how details serve detection. Existing super-resolution-assisted detectors generally follow a restoration-first paradigm to explicitly enhance inputs before detection, which implicitly assumes visual fidelity benefits recognition. Yet super-resolution favors dense texture and edge recovery, while object detection relies on sparse instance-level semantics, making restoration amplify visually plausible but semantically irrelevant background textures. To tackle this issue, we propose CoLR-Det, a Collaborative Latent-Restoration-Assisted Small Object Detection framework that treats super-resolution supervision as detection-oriented latent regularization rather than explicit image-level enhancement. Instead of reconstructing high-resolution images for inference, CoLR-Det uses a training-only restoration branch to impose auxiliary reconstruction constraints on shared multiscale representations, and the inference pathway remains purely detection-driven. We further design a saliency-guided object-preserving token routing mechanism, which prioritizes high-saliency tokens for attention-based refinement while retaining information of bypassed tokens. Besides, a detection-prioritized two-stage optimization strategy is developed: it first builds stable object-level semantics before introducing restoration supervision, and assigns a smaller learning rate to the SR decoder to keep its updates conservative and reduce perturbations in collaborative training. With this design, CoLR-Det transforms restoration from an explicit visual enhancement operator into an implicit semantic regularizer. Experiments on resolution-degraded NWPU VHR-10-Split, DOTAv1.5-Split and HRSSD-Split show that CoLR-Det outperforms state-of-the-art methods, with code available at https://github.com/qiruo-ya/CoLR-Det.

Existing film-restoration methods frequently fail under fast motion, producing limb disappearance and structural distortion due to inaccurate motion modeling. Moreover, high-resolution restoration under spatially-persistent and mixed defects remains insufficiently studied. We propose HaineiFRDM, a Film Restoration Diffusion Model that leverages the content modeling capability of diffusion models for content-aware restoration, removing defects while preserving scene structure.To enable scalable high-resolution restoration, we adopt a patch-wise strategy with position-aware global fusion modules to maintain cross-patch coherence. We further introduce a frequency-based module to enhance texture consistency and a patch-consistent inference framework to alleviate blocking artifacts introduced by patch-based processing.We also construct a film restoration dataset comprising categorized defect templates, professionally restored films, and realistic synthetic degradations.Extensive experiments demonstrate our superior restoration quality with strong structural consistency. Our design also reduces memory requirements, enabling high-resolution restoration on a single 24GB-VRAM GPU.Code and the dataset will be released at https://anonymous.4open.science/r/HaineiFRDM.

Image correction and rectangling are valuable tasks in practical photography systems such as smartphones. Recent remarkable advancements in deep learning have undeniably brought about substantial performance improvements in these fields. Nevertheless, existing methods mainly rely on task-specific architectures. This significantly restricts their generalization ability and effective application across a wide range of different tasks. In this paper, we introduce the Unified Rectification Framework (UniRect), a comprehensive approach that addresses these practical tasks from a consistent distortion rectification perspective. Our approach incorporates various task-specific inverse problems into a general distortion model by simulating different types of lenses. To handle diverse distortions, UniRect adopts one task-agnostic rectification framework with a dual-component structure: a {Deformation Module}, which utilizes a novel Residual Progressive Thin-Plate Spline (RP-TPS) model to address complex geometric deformations, and a subsequent Restoration Module, which employs Residual Mamba Blocks (RMBs) to counteract the degradation caused by the deformation process and enhance the fidelity of the output image. Moreover, a Sparse Mixture-of-Experts (SMoEs) structure is designed to circumvent heavy task competition in multi-task learning due to varying distortions. Extensive experiments demonstrate that our models have achieved state-of-the-art performance compared with other up-to-date methods.

Molecular structure elucidation from spectroscopic data is a long-standing challenge in Chemistry, traditionally requiring expert interpretation. We introduce NMIRacle, a two-stage generative framework that builds upon recent paradigms in AI-driven spectroscopy with minimal assumptions. In the first stage, NMIRacle learns to reconstruct molecular structures from count-aware fragment representations, capturing both fragment identities and their occurrences. In the second stage, a spectral encoder maps input spectra (IR, 1H-NMR, 13C-NMR) into a latent embedding used to condition the pre-trained generator, which is fine-tuned for direct spectra-to-molecule generation. This formulation bridges fragment-level chemical modeling with spectral evidence, yielding accurate molecular predictions. Empirical results demonstrate that NMIRacle outperforms existing baselines on molecular elucidation, while maintaining robust performance across increasing levels of molecular complexity.

Pre-trained image restoration models often fail on out-of-distribution (OOD) real-world degradations. Adapting to these domains is challenging as real-world data lacks paired ground truth, and unsupervised methods often require unstable architectural changes. We propose Generative Manifold Distillation (GMD), which reframes domain adaptation as geometric manifold alignment. GMD operates in a strictly unpaired setting, requiring only low-quality (LQ) target observations. By leveraging the flow-matching dynamics of a frozen text-to-image foundation model, GMD projects off-manifold restorations onto the natural image manifold to generate high-quality pseudo-targets. To ensure stability, a quality-gated manifold filter rejects off-manifold samples, while source-anchored trajectory regularization prevents error accumulation. Ultimately, GMD distills a powerful generative prior into an efficient restoration network. Experiments demonstrate that GMD seamlessly adapts to new distributions using only LQ inputs, drastically improving perceptual quality with zero architectural modifications or added inference latency.

All-in-One Image Restoration (AiOIR) aims to recover high-quality images from diverse degradations within a unified framework. However, existing methods often fail to explicitly model degradation types and struggle to adapt their restoration behavior to complex or mixed degradations. To address these issues, we propose ClusIR, a Cluster-Guided Image Restoration framework that explicitly models degradation semantics through learnable clustering and propagates cluster-aware cues across spatial and frequency domains for adaptive restoration. Specifically, ClusIR comprises two key components: a Probabilistic Cluster-Guided Routing Mechanism (PCGRM) and a Degradation-Aware Frequency Modulation Module (DAFMM). The proposed PCGRM disentangles degradation recognition from expert activation, enabling discriminative degradation perception and stable expert routing. Meanwhile, DAFMM leverages the cluster-guided priors to perform adaptive frequency decomposition and targeted modulation, collaboratively refining structural and textural representations for higher restoration fidelity. The cluster-guided synergy seamlessly bridges semantic cues with frequency-domain modulation, empowering ClusIR to attain remarkable restoration results across a wide range of degradations. Extensive experiments on diverse benchmarks validate that ClusIR reaches competitive performance under several scenarios.

License plate image restoration is important not only as a preprocessing step for license plate recognition but also for enhancing evidential value, improving visual clarity, and enabling broader reuse of license plate images. We propose a novel diffusion-based framework with character-level guidance, CharDiff-LP, which effectively restores and recognizes severely degraded license plate images captured under realistic conditions. CharDiff-LP leverages fine-grained character-level priors extracted through external segmentation and Optical Character Recognition (OCR) modules tailored for low-quality license plate images. For precise and focused guidance, CharDiff-LP incorporates a novel Character-guided Attention through Region-wise Masking (CHARM) module, which ensures that each character's guidance is restricted to its own region, thereby avoiding interference with other regions. In experiments, CharDiff-LP significantly outperformed baseline restoration models in both restoration quality and recognition accuracy, achieving a 28.3% relative reduction in character error rate (CER) on the Roboflow-LP dataset compared with the best-performing baseline.

Diffusion models represent the state-of-the-art for solving inverse problems such as image restoration tasks. Diffusion-based inverse solvers incorporate a likelihood term to guide prior sampling, generating data consistent with the posterior distribution. However, due to the intractability of the likelihood, most methods rely on isotropic Gaussian approximations, which can push estimates off the data manifold and produce inconsistent, poor reconstructions. We propose Equivariance Regularized (EquiReg) diffusion, a general plug-in framework that improves posterior sampling by penalizing trajectories that deviate from the data manifold. EquiReg formalizes manifold-preferential equivariant functions that exhibit low equivariance error for on-manifold samples and high error for off-manifold ones, thereby guiding sampling toward symmetry-preserving regions of the solution space. We highlight that such functions naturally emerge when training non-equivariant models with augmentation or on data with symmetries. EquiReg's largest gains are under reduced sampling and measurement consistency steps, where many methods suffer severe quality degradation. By regularizing trajectories toward the manifold, EquiReg implicitly accelerates convergence and enables high-quality reconstructions. EquiReg consistently improves performance in linear and nonlinear image restoration tasks and solving partial differential equations. Our code is available at https://github.com/Anima-Lab/EquiReg

Image demoiréing remains a challenging task due to the complex interplay between texture corruption and color distortions caused by moiré patterns. Existing methods, especially those relying on direct image-to-image restoration, often fail to disentangle these intertwined artifacts effectively. While frequency-aware approaches offer a promising direction, their potential is hindered by the discrete transform (e.g., Haar wavelet or block-based DCT), which may suffer from spatial discontinuity, channel redundancy, and further cause error accumulation during their fixed inverse processes. In this paper, we present Freqformer, a Transformer-based framework specifically designed for image demoiréing through targeted frequency separation. Our method performs an effective frequency decomposition that splits moiré patterns into high-frequency spatially-localized textures and low-frequency scale-robust color distortions, which are then handled by a dual-branch architecture and an asymmetric training scheme tailored to their distinct characteristics. We further propose a learnable Frequency Composition Transform (FCT) module to adaptively fuse the frequency-specific outputs, enabling consistent and high-fidelity reconstruction. To better aggregate the spatial dependencies and the inter-channel complementary information, we introduce a Spatial-Aware Channel Attention (SA-CA) module that refines moiré-sensitive regions without incurring high computational cost. Extensive experiments on various demoiréing benchmarks demonstrate that Freqformer achieves state-of-the-art performance with a compact model size. The code will be made publicly available at https://github.com/xyLiu339/Freqformer.

Transformer-based models have made remarkable progress in image restoration (IR) tasks. However, the quadratic complexity of self-attention in Transformer hinders its applicability to high-resolution images. Existing methods mitigate this issue with sparse or window-based attention, yet inherently limit global context modeling. Linear attention, a variant of softmax attention, demonstrates promise in global context modeling while maintaining linear complexity, offering a potential solution to the above challenge. Despite its efficiency benefits, vanilla linear attention suffers from a significant performance drop in IR, largely due to the low-rank nature of its attention map. To counter this, we propose Rank Enhanced Linear Attention (RELA), a simple yet effective method that enriches feature representations by integrating a lightweight depthwise convolution. Building upon RELA, we propose an efficient and effective Vision Transformer, named LAformer. LAformer eliminates hardware-inefficient operations such as softmax and window shifting, enabling efficient processing of high-resolution images. Extensive experiments across 7 IR tasks and 21 benchmarks demonstrate that LAformer outperforms SOTA methods and offers significant computational advantages. Furthermore, we extend LAformer to diffusion-based and flow-based visual generation, showcasing its strong potential as a competitive alternative to DiT and SiT. Code and models are available at https://github.com/shallowdream204/LAformer.

Utilities publish Estimated Times of Restoration (ETRs) for customer-facing storm outages, and their accuracy governs whether customers can make sound decisions about food, medical equipment, and relocation. Prior work treats ETR as static tabular regression in which each outage contributes one record, discarding the fact that every development of an outage, from crew assignment through dispatch, suspension, damage assessment and partial restoration, is recorded as a revision. We reformulate ETR prediction as longitudinal tabular regression and introduce a Longitudinal Tabular Transformer (LTT), an axial-attention model that consumes the revisions preceding a prediction and issues a refined estimate at every one. On 242{,}928 storm-attributed outages from a cohort of 526{,}468 filtered events and 10.0 million revisions at six operating companies, LTT reduces customer-weighted asymmetric error at all six, by a median of 36.9,% against the estimates the utilities published during the same storms and 11.3,% against the strongest learned baseline at each. It is the only method improving on the incumbent's satisfaction impact at all six companies while also reducing root mean squared error at all six. Stratification by revision index shows that LTT error is largest at the first revision, where no history is available, and falls monotonically as revisions accumulate.

Imaging through inhomogeneous media often results in severe distortions, posing significant challenges to downstream image-processing tasks. The lack of clean paired images makes supervised learning impractical, motivating unsupervised restoration approaches. In this work, we propose the Circular Quasi-Conformal Deturbulence (CQCD) framework, an unsupervised approach that reconstructs distortion-free images from multiple frames using a circular architecture. The framework minimizes reconstruction errors by jointly estimating forward and backward transformations between distorted observations and the restored image. A key advancement of CQCD is the integration of computational quasi-conformal geometry, which encourages bijective non-rigid deformations and improves the well-posedness of both forward and inverse mappings for cycle consistency. The deformation field is further regularized to preserve structural coherence and reduce non-physical artifacts such as folding or tearing. Additionally, tight-frame blocks are employed to effectively encode distortion-sensitive features, enhancing the precision of the restoration process. To assess the effectiveness of the proposed framework, extensive evaluations are conducted on synthetic and real-world image datasets. Experimental findings indicate that CQCD not only surpasses existing state-of-the-art deturbulence techniques in restoration quality but also achieves highly accurate deformation field estimation.

Hyperspectral imaging is a powerful bioimaging tool which can uncover novel insights, thanks to its sensitivity to the intrinsic properties of materials. However, this enhanced contrast comes at the cost of system complexity, constrained by an inherent trade-off between spatial, spectral, and temporal resolution. To overcome this limitation, we present a self-supervised deep learning-based approach that restores and enhances pixel resolution post-acquisition without requiring external training data beyond the images to be restored. Fine-tuned using metrics aligned with the imaging model, our physics-aware method achieves a 16$\times$ pixel super-resolution enhancement and a 12$\times$ imaging speedup without the need of additional training data for transfer learning. Applied to both synthetic and experimental data from five different sample types, including healthy and diseased tissues, we demonstrate that the model preserves biological integrity, as we did not detect systematic loss of biological features or biologically consequential hallucinations in tested datasets. We also concretely demonstrate the model's ability to reveal disease-associated metabolic changes that would otherwise remain undetectable. Furthermore, we provide physical insights into the model's inner workings, paving the way for future refinements that could potentially reveal novel high resolution features in an explainable manner. All methods are available as open-source software on GitHub.

Slice-to-volume reconstruction (SVR) is the standard method for obtaining high-resolution (HR) 3D fetal brain volumes from motion-corrupted 2D MRI slice stacks acquired in multiple orientations. Existing SVR methods are optimized and validated only for clinical-range echo times (TEs), limiting their use at non-clinical TEs and making them incompatible with quantitative T2 mapping, a protocol- and center-independent biomarker of fetal brain maturation requiring HR reconstructions across multiple TEs. We present PRIME-SVR, the first implicit neural representation (INR) framework for joint HR reconstruction from multi-echo MRI. A single fully connected network models a continuous function from spatial coordinates to signal intensities across TEs, while a second network estimates slice-specific acquisition degradations. Cross-TE coherence is enforced via a Bloch equation-derived regularization penalizing deviations from expected T2 decay, with adaptive weighting that strengthens coupling for degraded stacks. The method is fully self-supervised. We validate PRIME-SVR on 39 in vivo fetal acquisitions (13 subjects x 3 TEs) from two centers, two vendors, and two field strengths (1.5 T and 0.55 T). Compared to state-of-the-art SVR, PRIME-SVR improves reconstruction sharpness by 47%, anatomical accuracy by 30%, and cross-TE structural consistency by 14%. It enables reconstruction at late TEs previously inaccessible to SVR, yielding the first 0.8 mm isotropic T2 maps at 0.55 T and the first T2 maps derived from INR-based SVR. PRIME-SVR also accelerates quantitative imaging by reducing the data needed for multi-TE reconstruction, cutting acquisition from 15 to 10 minutes while keeping T2 accuracy within 1.7% in white and deep gray matter, or to 5 minutes with a mean T2 error of 2.3% for high-quality acquisitions.

We present Lunima-OmniLV (abbreviated as OmniLV), a universal multimodal multi-task framework for low-level vision that addresses over 100 sub-tasks across four major categories: image restoration, image enhancement, weak-semantic dense prediction, and stylization. OmniLV leverages both textual and visual prompts to offer flexible and user-friendly interactions. Built on Diffusion Transformer (DiT)-based generative priors, our framework supports arbitrary resolutions -- achieving optimal performance at 1K resolution -- while preserving fine-grained details and high fidelity. Through extensive experiments, we demonstrate that separately encoding text and visual instructions, combined with co-training using shallow feature control, is essential to mitigate task ambiguity and enhance multi-task generalization. Our findings also reveal that integrating high-level generative tasks into low-level vision models can compromise detail-sensitive restoration. These insights pave the way for more robust and generalizable low-level vision systems.